Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epid...

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Vydané v:	International journal of molecular sciences Ročník 21; číslo 3; s. 712
Hlavní autori:	Sirufo, Maria Maddalena, Suppa, Mariano, Ginaldi, Lia, De Martinis, Massimo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 21.01.2020 MDPI
Predmet:	Allergens Allergies Animals Asthma Asthma - immunology Autophagy Bone and Bones - immunology Bone marrow Cell Proliferation Chemokines Chronic illnesses Chronic Urticaria Cytokines Cytokines - metabolism Dendritic cells Dermatitis, Atopic Disease Eczema Eosinophils - immunology Fractures Fractures, Bone - immunology Fractures, Bone - pathology Growth factors Health risk assessment Histamine Humans Hypereosinophilic Syndrome Hypersensitivity - complications Hypersensitivity - immunology Hypersensitivity - pathology Immune system Inflammation Inflammation Mediators Job Syndrome Kinases Lymphocytes Mast Cells Mastocytosis Metabolism Milk Osteoporosis Osteoporosis - complications Osteoporosis - immunology Osteoporosis - pathology Pathogenesis Review Rhinitis, Allergic, Seasonal Transcription factors Urticaria - immunology Vitamin D Womens health skeletal health hypersensitivity translational immunology IgE urticaria eczema allergy asthma bone eosinophil osteoporosis mastocyte
ISSN:	1422-0067, 1661-6596, 1422-0067
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Shrnutí:	Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms21030712