Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy

Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epid...

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Published in:International journal of molecular sciences Vol. 21; no. 3; p. 712
Main Authors: Sirufo, Maria Maddalena, Suppa, Mariano, Ginaldi, Lia, De Martinis, Massimo
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 21.01.2020
MDPI
Subjects:
Allergens
Allergies
Animals
Asthma
Asthma - immunology
Autophagy
Bone and Bones - immunology
Bone marrow
Cell Proliferation
Chemokines
Chronic illnesses
Chronic Urticaria
Cytokines
Cytokines - metabolism
Dendritic cells
Dermatitis, Atopic
Disease
Eczema
Eosinophils - immunology
Fractures
Fractures, Bone - immunology
Fractures, Bone - pathology
Growth factors
Health risk assessment
Histamine
Humans
Hypereosinophilic Syndrome
Hypersensitivity - complications
Hypersensitivity - immunology
Hypersensitivity - pathology
Immune system
Inflammation
Inflammation Mediators
Job Syndrome
Kinases
Lymphocytes
Mast Cells
Mastocytosis
Metabolism
Milk
Osteoporosis
Osteoporosis - complications
Osteoporosis - immunology
Osteoporosis - pathology
Pathogenesis
Review
Rhinitis, Allergic, Seasonal
Transcription factors
Urticaria - immunology
Vitamin D
Womens health
skeletal health
hypersensitivity
translational immunology
IgE
urticaria
eczema
allergy
asthma
bone
eosinophil
osteoporosis
mastocyte
ISSN:1422-0067, 1661-6596, 1422-0067
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Abstract Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation.
AbstractList Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation.
: Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation.: Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent processes, and they were considered unrelated. However, the increasing knowledge in the field of osteoimmunology and an increasing number of epidemiological and biological studies have provided support to a correlation between bone and allergy that share pathways, cells, cytokines and mediators. If the link between allergic pathology and bone alterations appears more subtle, there are conditions such as mastocytosis and hypereosinophilic or hyper-IgE syndromes characterized by the proliferation of cells or hyper-production of molecules that play a key role in allergies, in which this link is at least clinically more evident, and the diseases are accompanied by frank skeletal involvement, offering multiple speculation cues. The pathophysiological connection of allergy and osteoporosis is currently an intriguing area of research. The aim of this review is to summarize and bring together the current knowledge and pursue an opportunity to stimulate further investigation.
Author Ginaldi, Lia
Sirufo, Maria Maddalena
De Martinis, Massimo
Suppa, Mariano
AuthorAffiliation 1 Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy; maddalena.sirufo@gmail.com (M.M.S.); lia.ginaldi@cc.univaq.it (L.G.)
2 Allergy and Clinical Immunology Unit, Center for the diagnosis and treatment of Osteoporosis, AUSL 04 Teramo, 64100 Teramo, Italy
3 Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium; dr.marianosuppa@gmail.com
AuthorAffiliation_xml – name: 3 Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium; dr.marianosuppa@gmail.com
– name: 1 Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy; maddalena.sirufo@gmail.com (M.M.S.); lia.ginaldi@cc.univaq.it (L.G.)
– name: 2 Allergy and Clinical Immunology Unit, Center for the diagnosis and treatment of Osteoporosis, AUSL 04 Teramo, 64100 Teramo, Italy
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Issue 3
Keywords skeletal health
hypersensitivity
translational immunology
IgE
urticaria
eczema
allergy
asthma
bone
eosinophil
osteoporosis
mastocyte
Language English
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Snippet Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent...
: Osteoporosis and allergic diseases are important causes of morbidity, and traditionally their coexistence has been attributed to causality, to independent...
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SubjectTerms Allergens
Allergies
Animals
Asthma
Asthma - immunology
Autophagy
Bone and Bones - immunology
Bone marrow
Cell Proliferation
Chemokines
Chronic illnesses
Chronic Urticaria
Cytokines
Cytokines - metabolism
Dendritic cells
Dermatitis, Atopic
Disease
Eczema
Eosinophils - immunology
Fractures
Fractures, Bone - immunology
Fractures, Bone - pathology
Growth factors
Health risk assessment
Histamine
Humans
Hypereosinophilic Syndrome
Hypersensitivity - complications
Hypersensitivity - immunology
Hypersensitivity - pathology
Immune system
Inflammation
Inflammation Mediators
Job Syndrome
Kinases
Lymphocytes
Mast Cells
Mastocytosis
Metabolism
Milk
Osteoporosis
Osteoporosis - complications
Osteoporosis - immunology
Osteoporosis - pathology
Pathogenesis
Review
Rhinitis, Allergic, Seasonal
Transcription factors
Urticaria - immunology
Vitamin D
Womens health
Title Does Allergy Break Bones? Osteoporosis and Its Connection to Allergy
URI https://www.ncbi.nlm.nih.gov/pubmed/31973226
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https://pubmed.ncbi.nlm.nih.gov/PMC7037724
Volume 21
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