Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis

Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota co...

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Published in:	International journal of molecular sciences Vol. 21; no. 11; p. 4093
Main Authors:	Machate, David Johane, Figueiredo, Priscila Silva, Marcelino, Gabriela, Guimarães, Rita de Cássia Avellaneda, Hiane, Priscila Aiko, Bogo, Danielle, Pinheiro, Verônica Assalin Zorgetto, Oliveira, Lincoln Carlos Silva de, Pott, Arnildo
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 08.06.2020 MDPI
Subjects:	Animals Cholesterol Diabetes Diet Diet, High-Fat Dysbiosis Energy Energy Metabolism Fatty acids Fatty Acids - metabolism Fatty Acids, Unsaturated - metabolism Fatty Acids, Volatile - metabolism Gastrointestinal Microbiome Gut microbiota Health promotion Human subjects Humans Inflammatory bowel disease Insulin resistance Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolism Metabolites Microbiota Obesity Obesity - etiology Obesity - metabolism Oils & fats Polyunsaturated fatty acids Review health inflammatory diseases intestinal bacteria short-chain fatty acids diabetes hypertension
ISSN:	1422-0067, 1661-6596, 1422-0067
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Abstract	Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n–3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts.
AbstractList	Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n-3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts.Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n-3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts. Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n–3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts.
Author	Hiane, Priscila Aiko Bogo, Danielle Oliveira, Lincoln Carlos Silva de Figueiredo, Priscila Silva Machate, David Johane Pinheiro, Verônica Assalin Zorgetto Marcelino, Gabriela Guimarães, Rita de Cássia Avellaneda Pott, Arnildo
AuthorAffiliation	3 Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil; lincoln.oliveira@ufms.br 2 Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil; pri.figueiredo92@gmail.com (P.S.F.); gabi19ac@gmail.com (G.M.); priscila.hiane@ufms.br (P.A.H.); daniellebogo@hotmail.com (D.B.); veronica.azp@outlook.com (V.A.Z.P.) 1 Graduate Program in Biotechnology and Biodiversity in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil; machatedavidjohanemachate@yahoo.com.br (D.J.M.); arnildo.pott@gmail.com (A.P.)
AuthorAffiliation_xml	– name: 3 Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil; lincoln.oliveira@ufms.br – name: 1 Graduate Program in Biotechnology and Biodiversity in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil; machatedavidjohanemachate@yahoo.com.br (D.J.M.); arnildo.pott@gmail.com (A.P.) – name: 2 Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil; pri.figueiredo92@gmail.com (P.S.F.); gabi19ac@gmail.com (G.M.); priscila.hiane@ufms.br (P.A.H.); daniellebogo@hotmail.com (D.B.); veronica.azp@outlook.com (V.A.Z.P.)
Author_xml	– sequence: 1 givenname: David Johane surname: Machate fullname: Machate, David Johane – sequence: 2 givenname: Priscila Silva orcidid: 0000-0003-4047-9602 surname: Figueiredo fullname: Figueiredo, Priscila Silva – sequence: 3 givenname: Gabriela orcidid: 0000-0003-0015-6083 surname: Marcelino fullname: Marcelino, Gabriela – sequence: 4 givenname: Rita de Cássia Avellaneda surname: Guimarães fullname: Guimarães, Rita de Cássia Avellaneda – sequence: 5 givenname: Priscila Aiko orcidid: 0000-0003-1115-4083 surname: Hiane fullname: Hiane, Priscila Aiko – sequence: 6 givenname: Danielle surname: Bogo fullname: Bogo, Danielle – sequence: 7 givenname: Verônica Assalin Zorgetto orcidid: 0000-0001-8898-4216 surname: Pinheiro fullname: Pinheiro, Verônica Assalin Zorgetto – sequence: 8 givenname: Lincoln Carlos Silva de orcidid: 0000-0003-1281-3431 surname: Oliveira fullname: Oliveira, Lincoln Carlos Silva de – sequence: 9 givenname: Arnildo orcidid: 0000-0002-8599-9276 surname: Pott fullname: Pott, Arnildo
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32521778$$D View this record in MEDLINE/PubMed
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Keywords	health inflammatory diseases intestinal bacteria short-chain fatty acids diabetes hypertension
Language	English
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Snippet	Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly...
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SubjectTerms	Animals Cholesterol Diabetes Diet Diet, High-Fat Dysbiosis Energy Energy Metabolism Fatty acids Fatty Acids - metabolism Fatty Acids, Unsaturated - metabolism Fatty Acids, Volatile - metabolism Gastrointestinal Microbiome Gut microbiota Health promotion Human subjects Humans Inflammatory bowel disease Insulin resistance Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolism Metabolites Microbiota Obesity Obesity - etiology Obesity - metabolism Oils & fats Polyunsaturated fatty acids Review
Title	Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis
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