An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen species with the pathophysiology of Alzheimer’s...

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Vydané v:International journal of molecular sciences Ročník 23; číslo 11; s. 5938
Hlavní autori: Teleanu, Daniel Mihai, Niculescu, Adelina-Gabriela, Lungu, Iulia Ioana, Radu, Crina Ioana, Vladâcenco, Oana, Roza, Eugenia, Costăchescu, Bogdan, Grumezescu, Alexandru Mihai, Teleanu, Raluca Ioana
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 25.05.2022
MDPI
Predmet:
Alzheimer's disease
Antioxidants
Antioxidants - therapeutic use
Cytochrome
Cytotoxicity
Dehydrogenases
Dopamine
Enzymes
Humans
Huntingtons disease
Metabolism
Mitochondria
Neurodegenerative Diseases - pathology
Neuroinflammatory Diseases
Neurons
Oxidation
Oxidative stress
Oxidative Stress - physiology
Parkinson's disease
Reactive Oxygen Species
Review
neurodegenerative disease
antioxidants
neuroinflammation
reactive oxidative species
ISSN:1422-0067, 1661-6596, 1422-0067
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Shrnutí:Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen species with the pathophysiology of Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Oxidative stress was also noted to modify the inflammatory response. Even though oxidative stress and neuroinflammation are two totally different pathological events, they are linked and affect one another. Nonetheless, there are still several mechanisms that need to be understood regarding the onset and the progress of neurodegenerative diseases in order to develop efficient therapies. As antioxidants are a means to alter oxidative stress and slow down the symptoms of these neurodegenerative diseases, the most common antioxidants, enzymatic as well as non-enzymatic, have been mentioned in this paper as therapeutic options for the discussed disorders.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23115938