Recent Advances in Electrochemical Sensing of Hydrogen Peroxide (H2O2) Released from Cancer Cells

Cancer is by far the most common cause of death worldwide. There are more than 200 types of cancer known hitherto depending upon the origin and type. Early diagnosis of cancer provides better disease prognosis and the best chance for a cure. This fact prompts world-leading scientists and clinicians...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Vol. 12; no. 9; p. 1475
Main Authors: Ahmad, Touqeer, Iqbal, Ayesha, Halim, Sobia Ahsan, Uddin, Jalal, Khan, Ajmal, El Deeb, Sami, Al-Harrasi, Ahmed
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 26.04.2022
MDPI
Subjects:
analytical methods
Biomarkers
Biosensors
Cancer
carbon materials
Chemical sensors
Chemiluminescence
Colorimetry
Conjugation
Diagnosis
Electrical measurement
electrochemical sensing
Electrochemistry
Fluorimetry
H2O2
Hydrogen peroxide
Medical prognosis
Morbidity
Nanocomposites
nanomaterial
Nanomaterials
Nanotechnology
Review
Selectivity
Spectrophotometry
Titration
United States > US
nanomaterial
carbon materials
biosensors
electrochemical sensing
H2O2
analytical methods
ISSN:2079-4991, 2079-4991
Online Access:Get full text
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Summary:Cancer is by far the most common cause of death worldwide. There are more than 200 types of cancer known hitherto depending upon the origin and type. Early diagnosis of cancer provides better disease prognosis and the best chance for a cure. This fact prompts world-leading scientists and clinicians to develop techniques for the early detection of cancer. Thus, less morbidity and lower mortality rates are envisioned. The latest advancements in the diagnosis of cancer utilizing nanotechnology have manifested encouraging results. Cancerous cells are well known for their substantial amounts of hydrogen peroxide (H2O2). The common methods for the detection of H2O2 include colorimetry, titration, chromatography, spectrophotometry, fluorimetry, and chemiluminescence. These methods commonly lack selectivity, sensitivity, and reproducibility and have prolonged analytical time. New biosensors are reported to circumvent these obstacles. The production of detectable amounts of H2O2 by cancerous cells has promoted the use of bio- and electrochemical sensors because of their high sensitivity, selectivity, robustness, and miniaturized point-of-care cancer diagnostics. Thus, this review will emphasize the principles, analytical parameters, advantages, and disadvantages of the latest electrochemical biosensors in the detection of H2O2. It will provide a summary of the latest technological advancements of biosensors based on potentiometric, impedimetric, amperometric, and voltammetric H2O2 detection. Moreover, it will critically describe the classification of biosensors based on the material, nature, conjugation, and carbon-nanocomposite electrodes for rapid and effective detection of H2O2, which can be useful in the early detection of cancerous cells.
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ISSN:2079-4991
2079-4991
DOI:10.3390/nano12091475