Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels

Disruption of the endocannabinoid system through pharmacological or genetic invalidation of cannabinoid CB1 receptors has been linked to depression in humans and depression-like behaviors in mice. The two main endogenous cannabinoids, anandamide and 2-arachidonoyl glycerol (2-AG), are produced on de...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 79; no. 10; pp. 858 - 868
Main Authors:	Jenniches, Imke, Ternes, Svenja, Albayram, Onder, Otte, David M., Bach, Karsten, Bindila, Laura, Michel, Kerstin, Lutz, Beat, Bilkei-Gorzo, Andras, Zimmer, Andreas
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15.05.2016
Subjects:	Animals Anxiety Anxiety - metabolism Brain - metabolism Cannabinoids Cohort Studies Dagla Depression Endocannabinoids - metabolism Exploratory Behavior - physiology Extinction, Psychological - physiology Fear - physiology Fear extinction Female Lipoprotein Lipase - deficiency Lipoprotein Lipase - genetics Male Maternal Behavior - physiology Mice, Inbred C57BL Mice, Knockout Motor Activity - physiology Neurogenesis - physiology Psychiatric/Mental Health Social Behavior Stress Stress, Psychological - metabolism Fear extinction Depression Cannabinoids Anxiety Dagla Stress
ISSN:	0006-3223, 1873-2402
Online Access:	Get full text
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