New Insights to Regulation of Fructose-1,6-bisphosphatase during Anoxia in Red-Eared Slider, Trachemys scripta elegans

The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its metabolic rate drops drastically to minimize energy requirements. The alterations in the central metabolic pathways are of...

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Published in:	Biomolecules (Basel, Switzerland) Vol. 11; no. 10; p. 1548
Main Authors:	Gupta, Aakriti, Varma, Anchal, Storey, Kenneth B.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 19.10.2021 MDPI
Subjects:	Anaerobic conditions Animals Anoxia Dehydrogenases Energy requirements enzyme regulation Enzymes Fructose Fructose - genetics Fructose - metabolism Fructose-1,6-bisphosphatse Fructose-1,6-diphosphate Fructose-Bisphosphatase - metabolism Gluconeogenesis Glucose Glycerol Homogenization Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Immunoblotting Kinases Liver Liver - metabolism Metabolic pathways Metabolic rate metabolic rate depression Metabolism Oxygen - metabolism Phosphorylation Phosphorylation - genetics Post-translation Protein Processing, Post-Translational Proteins Signal Transduction - genetics Threonine Trachemys scripta elegans Turtles - metabolism Canada United States > US Quebec Canada Fructose-1,6-bisphosphatse metabolic rate depression Trachemys scripta elegans anoxia enzyme regulation post-translational modification gluconeogenesis
ISSN:	2218-273X, 2218-273X
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Abstract	The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its metabolic rate drops drastically to minimize energy requirements. The alterations in the central metabolic pathways are often accomplished by the regulation of key enzymes. The regulation of one such enzyme, fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), was characterized in the present study during anoxia in liver. FBPase is a crucial enzyme of gluconeogenesis. The FBPase was purified from liver tissue in both control and anoxic conditions and subsequently assayed to determine the kinetic parameters of the enzyme. The study revealed the relative degree of post-translational modifications in the FBPase from control and anoxic turtles. Further, this study demonstrated a significant decrease in the maximal activity in anoxic FBPase and decreased sensitivity to its substrate Fructose-1,6-bisphosphate (FBP) when compared to the control. Immunoblotting demonstrated increased threonine phosphorylation (~1.4-fold) in the anoxic FBPase. Taken together, these results suggest that the phosphorylation of liver FBPase is an important step in suppressing FBPase activity, ultimately leading to the inhibition of gluconeogenesis in the liver of the red-eared slider during anaerobic conditions.
AbstractList	The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its metabolic rate drops drastically to minimize energy requirements. The alterations in the central metabolic pathways are often accomplished by the regulation of key enzymes. The regulation of one such enzyme, fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), was characterized in the present study during anoxia in liver. FBPase is a crucial enzyme of gluconeogenesis. The FBPase was purified from liver tissue in both control and anoxic conditions and subsequently assayed to determine the kinetic parameters of the enzyme. The study revealed the relative degree of post-translational modifications in the FBPase from control and anoxic turtles. Further, this study demonstrated a significant decrease in the maximal activity in anoxic FBPase and decreased sensitivity to its substrate Fructose-1,6-bisphosphate (FBP) when compared to the control. Immunoblotting demonstrated increased threonine phosphorylation (~1.4-fold) in the anoxic FBPase. Taken together, these results suggest that the phosphorylation of liver FBPase is an important step in suppressing FBPase activity, ultimately leading to the inhibition of gluconeogenesis in the liver of the red-eared slider during anaerobic conditions. The red-eared slider ( ) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its metabolic rate drops drastically to minimize energy requirements. The alterations in the central metabolic pathways are often accomplished by the regulation of key enzymes. The regulation of one such enzyme, fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), was characterized in the present study during anoxia in liver. FBPase is a crucial enzyme of gluconeogenesis. The FBPase was purified from liver tissue in both control and anoxic conditions and subsequently assayed to determine the kinetic parameters of the enzyme. The study revealed the relative degree of post-translational modifications in the FBPase from control and anoxic turtles. Further, this study demonstrated a significant decrease in the maximal activity in anoxic FBPase and decreased sensitivity to its substrate Fructose-1,6-bisphosphate (FBP) when compared to the control. Immunoblotting demonstrated increased threonine phosphorylation (~1.4-fold) in the anoxic FBPase. Taken together, these results suggest that the phosphorylation of liver FBPase is an important step in suppressing FBPase activity, ultimately leading to the inhibition of gluconeogenesis in the liver of the red-eared slider during anaerobic conditions. The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its metabolic rate drops drastically to minimize energy requirements. The alterations in the central metabolic pathways are often accomplished by the regulation of key enzymes. The regulation of one such enzyme, fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), was characterized in the present study during anoxia in liver. FBPase is a crucial enzyme of gluconeogenesis. The FBPase was purified from liver tissue in both control and anoxic conditions and subsequently assayed to determine the kinetic parameters of the enzyme. The study revealed the relative degree of post-translational modifications in the FBPase from control and anoxic turtles. Further, this study demonstrated a significant decrease in the maximal activity in anoxic FBPase and decreased sensitivity to its substrate Fructose-1,6-bisphosphate (FBP) when compared to the control. Immunoblotting demonstrated increased threonine phosphorylation (~1.4-fold) in the anoxic FBPase. Taken together, these results suggest that the phosphorylation of liver FBPase is an important step in suppressing FBPase activity, ultimately leading to the inhibition of gluconeogenesis in the liver of the red-eared slider during anaerobic conditions.The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its metabolic rate drops drastically to minimize energy requirements. The alterations in the central metabolic pathways are often accomplished by the regulation of key enzymes. The regulation of one such enzyme, fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), was characterized in the present study during anoxia in liver. FBPase is a crucial enzyme of gluconeogenesis. The FBPase was purified from liver tissue in both control and anoxic conditions and subsequently assayed to determine the kinetic parameters of the enzyme. The study revealed the relative degree of post-translational modifications in the FBPase from control and anoxic turtles. Further, this study demonstrated a significant decrease in the maximal activity in anoxic FBPase and decreased sensitivity to its substrate Fructose-1,6-bisphosphate (FBP) when compared to the control. Immunoblotting demonstrated increased threonine phosphorylation (~1.4-fold) in the anoxic FBPase. Taken together, these results suggest that the phosphorylation of liver FBPase is an important step in suppressing FBPase activity, ultimately leading to the inhibition of gluconeogenesis in the liver of the red-eared slider during anaerobic conditions.
Author	Storey, Kenneth B. Varma, Anchal Gupta, Aakriti
AuthorAffiliation	Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada; aakritigupta@cmail.carleton.ca (A.G.); anchalvarma@cmail.carleton.ca (A.V.)
AuthorAffiliation_xml	– name: Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada; aakritigupta@cmail.carleton.ca (A.G.); anchalvarma@cmail.carleton.ca (A.V.)
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34680181$$D View this record in MEDLINE/PubMed
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Keywords	Fructose-1,6-bisphosphatse metabolic rate depression Trachemys scripta elegans anoxia enzyme regulation post-translational modification gluconeogenesis
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Snippet	The red-eared slider (Trachemys scripta elegans) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During... The red-eared slider ( ) undergoes numerous changes to its physiological and metabolic processes to survive without oxygen. During anoxic conditions, its...
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SubjectTerms	Anaerobic conditions Animals Anoxia Dehydrogenases Energy requirements enzyme regulation Enzymes Fructose Fructose - genetics Fructose - metabolism Fructose-1,6-bisphosphatse Fructose-1,6-diphosphate Fructose-Bisphosphatase - metabolism Gluconeogenesis Glucose Glycerol Homogenization Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Immunoblotting Kinases Liver Liver - metabolism Metabolic pathways Metabolic rate metabolic rate depression Metabolism Oxygen - metabolism Phosphorylation Phosphorylation - genetics Post-translation Protein Processing, Post-Translational Proteins Signal Transduction - genetics Threonine Trachemys scripta elegans Turtles - metabolism
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Title	New Insights to Regulation of Fructose-1,6-bisphosphatase during Anoxia in Red-Eared Slider, Trachemys scripta elegans
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