Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

Abstract Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to increased therapy resistance and has been linked to genomic instability. Here, we tested the hypothesis that exposure...

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Vydané v:	Nucleic acids research Ročník 49; číslo 13; s. 7492 - 7506
Hlavní autori:	Bader, Samuel B, Ma, Tiffany S, Simpson, Charlotte J, Liang, Jiachen, Maezono, Sakura Eri B, Olcina, Monica M, Buffa, Francesca M, Hammond, Ester M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 21.07.2021
Predmet:	APOBEC Deaminases - metabolism Cell Hypoxia Cell Line, Tumor Cytidine Deaminase - metabolism Deamination DNA Replication Genome Integrity, Repair and Humans Hydroxyurea - toxicity Minor Histocompatibility Antigens - metabolism Neoplasms - enzymology Stress, Physiological - genetics
ISSN:	0305-1048, 1362-4962, 1362-4962
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