Pathophysiology of Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity a...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	International journal of molecular sciences Ročník 21; číslo 17; s. 6275
Hlavní autoři:	Galicia-Garcia, Unai, Benito-Vicente, Asier, Jebari, Shifa, Larrea-Sebal, Asier, Siddiqi, Haziq, Uribe, Kepa B., Ostolaza, Helena, Martín, César
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 30.08.2020 MDPI
Témata:	Animals Blood Glucose - metabolism Cardiovascular disease Diabetes Diabetes Mellitus, Type 2 - physiopathology Epidemiology Ethnicity Family medical history Genomes Glucose Homeostasis Humans Hyperglycemia Inflammation Insulin resistance Insulin Secretion Lifestyles Metabolism Mortality Musculoskeletal system Obesity Pathogenesis Pathophysiology Physiology Population Review Risk factors cardiovascular disease liver adipocyte muscle pathophysiology type 2 diabetes mellitus β-cell insulin resistance
ISSN:	1422-0067, 1661-6596, 1422-0067
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthesis and release of insulin, as well as in its detection are tightly regulated. Defects in any of the mechanisms involved in these processes can lead to a metabolic imbalance responsible for the development of the disease. This review analyzes the key aspects of T2DM, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance. For that purpose, we summarize the data gathered up until now, focusing especially on insulin synthesis, insulin release, insulin sensing and on the downstream effects on individual insulin-sensitive organs. The review also covers the pathological conditions perpetuating T2DM such as nutritional factors, physical activity, gut dysbiosis and metabolic memory. Additionally, because T2DM is associated with accelerated atherosclerosis development, we review here some of the molecular mechanisms that link T2DM and insulin resistance (IR) as well as cardiovascular risk as one of the most important complications in T2DM.
AbstractList	Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthesis and release of insulin, as well as in its detection are tightly regulated. Defects in any of the mechanisms involved in these processes can lead to a metabolic imbalance responsible for the development of the disease. This review analyzes the key aspects of T2DM, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance. For that purpose, we summarize the data gathered up until now, focusing especially on insulin synthesis, insulin release, insulin sensing and on the downstream effects on individual insulin-sensitive organs. The review also covers the pathological conditions perpetuating T2DM such as nutritional factors, physical activity, gut dysbiosis and metabolic memory. Additionally, because T2DM is associated with accelerated atherosclerosis development, we review here some of the molecular mechanisms that link T2DM and insulin resistance (IR) as well as cardiovascular risk as one of the most important complications in T2DM. Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthesis and release of insulin, as well as in its detection are tightly regulated. Defects in any of the mechanisms involved in these processes can lead to a metabolic imbalance responsible for the development of the disease. This review analyzes the key aspects of T2DM, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance. For that purpose, we summarize the data gathered up until now, focusing especially on insulin synthesis, insulin release, insulin sensing and on the downstream effects on individual insulin-sensitive organs. The review also covers the pathological conditions perpetuating T2DM such as nutritional factors, physical activity, gut dysbiosis and metabolic memory. Additionally, because T2DM is associated with accelerated atherosclerosis development, we review here some of the molecular mechanisms that link T2DM and insulin resistance (IR) as well as cardiovascular risk as one of the most important complications in T2DM.Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthesis and release of insulin, as well as in its detection are tightly regulated. Defects in any of the mechanisms involved in these processes can lead to a metabolic imbalance responsible for the development of the disease. This review analyzes the key aspects of T2DM, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance. For that purpose, we summarize the data gathered up until now, focusing especially on insulin synthesis, insulin release, insulin sensing and on the downstream effects on individual insulin-sensitive organs. The review also covers the pathological conditions perpetuating T2DM such as nutritional factors, physical activity, gut dysbiosis and metabolic memory. Additionally, because T2DM is associated with accelerated atherosclerosis development, we review here some of the molecular mechanisms that link T2DM and insulin resistance (IR) as well as cardiovascular risk as one of the most important complications in T2DM.
Author	Jebari, Shifa Uribe, Kepa B. Galicia-Garcia, Unai Benito-Vicente, Asier Siddiqi, Haziq Ostolaza, Helena Larrea-Sebal, Asier Martín, César
AuthorAffiliation	5 Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 182, 20014 Donostia San Sebastián, Spain; kbelloso@cicbiomagune.es 2 Biofisika Institute (UPV/EHU, CSIC), Barrio Sarriena s/n., 48940 Leioa (Bizkaia), Spain; asier.benito@ehu.eus (A.B.-V.); sjebari001@ikasle.ehu.eus (S.J.); ofbmaplc@ehu.es (H.O.) 1 Fundación Biofisika Bizkaia, Barrio Sarriena s/n., 48940 Leioa (Bizkaia), Spain; u.galiciag@gmail.com (U.G.-G.); asierlarrea@yahoo.es (A.L.-S.) 3 Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, Apdo. 644, 48080 Bilbao, Spain 4 Havard Medical School, 25 Shattuck St, Boston, MA 02115, USA; siddiqi.haziq1@gmail.com
AuthorAffiliation_xml	– name: 5 Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 182, 20014 Donostia San Sebastián, Spain; kbelloso@cicbiomagune.es – name: 1 Fundación Biofisika Bizkaia, Barrio Sarriena s/n., 48940 Leioa (Bizkaia), Spain; u.galiciag@gmail.com (U.G.-G.); asierlarrea@yahoo.es (A.L.-S.) – name: 2 Biofisika Institute (UPV/EHU, CSIC), Barrio Sarriena s/n., 48940 Leioa (Bizkaia), Spain; asier.benito@ehu.eus (A.B.-V.); sjebari001@ikasle.ehu.eus (S.J.); ofbmaplc@ehu.es (H.O.) – name: 3 Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, Apdo. 644, 48080 Bilbao, Spain – name: 4 Havard Medical School, 25 Shattuck St, Boston, MA 02115, USA; siddiqi.haziq1@gmail.com
Author_xml	– sequence: 1 givenname: Unai surname: Galicia-Garcia fullname: Galicia-Garcia, Unai – sequence: 2 givenname: Asier surname: Benito-Vicente fullname: Benito-Vicente, Asier – sequence: 3 givenname: Shifa surname: Jebari fullname: Jebari, Shifa – sequence: 4 givenname: Asier surname: Larrea-Sebal fullname: Larrea-Sebal, Asier – sequence: 5 givenname: Haziq surname: Siddiqi fullname: Siddiqi, Haziq – sequence: 6 givenname: Kepa B. surname: Uribe fullname: Uribe, Kepa B. – sequence: 7 givenname: Helena surname: Ostolaza fullname: Ostolaza, Helena – sequence: 8 givenname: César orcidid: 0000-0002-4087-8729 surname: Martín fullname: Martín, César
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32872570$$D View this record in MEDLINE/PubMed
BookMark	eNptkc1Lw0AQxRdR7IfePEvAi6DR2d1sNnsRpH5CRQ_1vGySTbslzdZsIuS_d0tbqcXTDMxvHu_NDNBhZSuN0BmGG0oF3Jr5whGMeUw4O0B9HBESAsT8cKfvoYFzcwBCCRPHqEdJwgnj0EdXH6qZ2eWsc8aWdtoFtggm3VIHJHgwKtWNdsGbLkvTtO4EHRWqdPp0U4fo8-lxMnoJx-_Pr6P7cZhFPGlCVrACKOOZAM6U96WjROQ5F0UCCVCBSVpgyFKaEiqilMSgRMpVnpGcqxQoHaK7te6yTRc6z3TV1KqUy9osVN1Jq4z8O6nMTE7tt-QMKCfcC1xuBGr71WrXyIVxmU-hKm1bJ0lERUyBCfDoxR46t21d-XieigAnwDj21Pmuo18r2zt6gKyBrLbO1bqQmWlUY-zKoCklBrl6ltx9ll-63lva6v6L_wC7kJQu
CitedBy_id	crossref_primary_10_1016_j_lfs_2020_118661 crossref_primary_10_1016_j_ijbiomac_2022_08_095 crossref_primary_10_1016_j_biopha_2022_113578 crossref_primary_10_22159_ajpcr_2025v18i9_55400 crossref_primary_10_3390_biology12020301 crossref_primary_10_1371_journal_pone_0285820 crossref_primary_10_1096_fj_202301316R crossref_primary_10_58545_jkki_v5i1_473 crossref_primary_10_1002_jcsm_12887 crossref_primary_10_1111_1750_3841_15939 crossref_primary_10_1016_j_carbpol_2024_122790 crossref_primary_10_1016_j_ejmech_2024_116939 crossref_primary_10_3390_nu15224706 crossref_primary_10_3390_pharmaceutics15041239 crossref_primary_10_1002_cbdv_202402806 crossref_primary_10_1016_j_prostaglandins_2023_106715 crossref_primary_10_1016_j_fitote_2025_106850 crossref_primary_10_1007_s10787_023_01242_9 crossref_primary_10_1038_s41598_024_54496_w crossref_primary_10_3389_fendo_2025_1601633 crossref_primary_10_3390_ijerph22030423 crossref_primary_10_1007_s40200_024_01426_2 crossref_primary_10_1155_2024_5540062 crossref_primary_10_1007_s13205_024_04178_1 crossref_primary_10_1016_j_jpbao_2025_100078 crossref_primary_10_3389_fendo_2023_1331739 crossref_primary_10_1007_s12602_024_10221_7 crossref_primary_10_3390_nu15132962 crossref_primary_10_1002_bit_28574 crossref_primary_10_3389_fnut_2022_1057825 crossref_primary_10_1177_25168657221130041 crossref_primary_10_3390_life13061322 crossref_primary_10_38124_ijisrt_25jul1474 crossref_primary_10_1016_j_intimp_2025_115069 crossref_primary_10_1016_j_ijbiomac_2024_137596 crossref_primary_10_3390_medicina61010083 crossref_primary_10_1016_j_jpha_2024_101130 crossref_primary_10_1007_s10068_024_01607_y crossref_primary_10_3390_biology14040424 crossref_primary_10_1016_j_peptides_2023_171096 crossref_primary_10_1080_01913123_2021_1983099 crossref_primary_10_1016_j_heliyon_2024_e35764 crossref_primary_10_1080_07391102_2025_2499224 crossref_primary_10_51723_hrj_v6i31_1140 crossref_primary_10_1007_s10557_023_07477_6 crossref_primary_10_1016_j_obmed_2024_100557 crossref_primary_10_1016_j_biopha_2025_118421 crossref_primary_10_1186_s12872_024_04463_0 crossref_primary_10_2147_DMSO_S446042 crossref_primary_10_2147_TCRM_S328056 crossref_primary_10_1080_07391102_2023_2291831 crossref_primary_10_20473_ijph_v18i2_2023_314_324 crossref_primary_10_1016_j_arabjc_2023_105170 crossref_primary_10_3390_metabo15010022 crossref_primary_10_1515_jcim_2024_0367 crossref_primary_10_1073_pnas_2206797120 crossref_primary_10_4239_wjd_v13_i10_809 crossref_primary_10_3389_fphys_2022_1063326 crossref_primary_10_3390_scipharm91010002 crossref_primary_10_1039_D1FO03941E crossref_primary_10_3390_ijms23010356 crossref_primary_10_1007_s00198_025_07523_z crossref_primary_10_1016_j_envpol_2023_122380 crossref_primary_10_3390_ijms221910835 crossref_primary_10_7759_cureus_65715 crossref_primary_10_1016_j_phyplu_2025_100849 crossref_primary_10_1002_ptr_70076 crossref_primary_10_3390_catal13020443 crossref_primary_10_1016_j_ejmech_2022_114171 crossref_primary_10_1155_2024_1240457 crossref_primary_10_3390_ijms25074070 crossref_primary_10_1016_j_biopha_2022_112697 crossref_primary_10_1097_CRD_0000000000001057 crossref_primary_10_1155_jdr_6523642 crossref_primary_10_4103_ijar_ijar_151_23 crossref_primary_10_1039_D4FO01675K crossref_primary_10_36303_SAPJ_0976 crossref_primary_10_1016_j_exer_2024_109790 crossref_primary_10_1089_jmf_2024_k_0251 crossref_primary_10_3390_ijms24087507 crossref_primary_10_1111_jfbc_14268 crossref_primary_10_1016_j_envres_2022_113259 crossref_primary_10_3390_ijms241210170 crossref_primary_10_3390_md22120554 crossref_primary_10_3390_brainsci13020165 crossref_primary_10_3389_fphar_2023_1276444 crossref_primary_10_1111_nmo_70154 crossref_primary_10_1002_jgh3_70200 crossref_primary_10_1007_s13410_024_01375_9 crossref_primary_10_20960_nh_05597 crossref_primary_10_3390_cells12081163 crossref_primary_10_2147_DMSO_S346648 crossref_primary_10_1088_1755_1315_1338_1_012026 crossref_primary_10_3389_fendo_2022_800714 crossref_primary_10_2147_DMSO_S392161 crossref_primary_10_1007_s10787_022_01049_0 crossref_primary_10_1080_10408398_2022_2101425 crossref_primary_10_1016_j_heliyon_2024_e24207 crossref_primary_10_1039_D4FO01544D crossref_primary_10_3390_ijms252313169 crossref_primary_10_1186_s40001_025_02682_5 crossref_primary_10_1016_j_cbi_2025_111443 crossref_primary_10_3389_fimmu_2025_1582119 crossref_primary_10_1016_j_jep_2023_116963 crossref_primary_10_1016_j_bbrep_2025_102037 crossref_primary_10_1016_j_humgen_2024_201362 crossref_primary_10_1080_10408398_2023_2255666 crossref_primary_10_1038_s41598_025_06263_8 crossref_primary_10_3390_ph18010069 crossref_primary_10_1007_s40200_023_01211_7 crossref_primary_10_12677_pi_2025_144027 crossref_primary_10_7759_cureus_46178 crossref_primary_10_1007_s12668_024_01786_2 crossref_primary_10_1038_s41366_023_01369_3 crossref_primary_10_3390_ijms26062770 crossref_primary_10_5812_jnms_164407 crossref_primary_10_3390_ijerph19010207 crossref_primary_10_3389_fphar_2025_1638147 crossref_primary_10_1186_s13287_024_03974_z crossref_primary_10_1016_j_fitote_2023_105803 crossref_primary_10_3390_biom14101316 crossref_primary_10_1016_j_pbiomolbio_2023_03_003 crossref_primary_10_3389_fendo_2024_1401070 crossref_primary_10_4239_wjd_v16_i8_106664 crossref_primary_10_3390_nu17071125 crossref_primary_10_3390_vetsci12060529 crossref_primary_10_1080_07853890_2024_2445181 crossref_primary_10_1016_j_joim_2022_07_004 crossref_primary_10_3390_cimb47070512 crossref_primary_10_1016_j_bbadis_2023_166900 crossref_primary_10_3390_ijms222413375 crossref_primary_10_1016_j_ijpharm_2023_122623 crossref_primary_10_3390_ph18091412 crossref_primary_10_1186_s40001_023_01424_9 crossref_primary_10_3390_molecules26185566 crossref_primary_10_1002_dmrr_3762 crossref_primary_10_56294_shp202231 crossref_primary_10_3390_ph18091409 crossref_primary_10_1016_j_fbio_2025_106234 crossref_primary_10_1016_j_joim_2025_05_005 crossref_primary_10_1186_s12902_023_01514_z crossref_primary_10_3390_cimb47070505 crossref_primary_10_1007_s10853_023_09148_1 crossref_primary_10_3390_pharmaceutics13111979 crossref_primary_10_1007_s13273_025_00507_4 crossref_primary_10_1097_MD_0000000000034021 crossref_primary_10_1038_s41598_025_02688_3 crossref_primary_10_3389_fendo_2024_1375459 crossref_primary_10_1016_j_biopha_2024_117641 crossref_primary_10_3390_v17070990 crossref_primary_10_1007_s10495_023_01854_0 crossref_primary_10_1080_07391102_2023_2292299 crossref_primary_10_1007_s00217_025_04842_7 crossref_primary_10_1038_s41368_022_00202_3 crossref_primary_10_1080_13813455_2023_2252204 crossref_primary_10_1016_j_scitotenv_2023_163592 crossref_primary_10_1186_s43162_024_00289_6 crossref_primary_10_1007_s44211_023_00444_z crossref_primary_10_1016_j_mce_2024_112195 crossref_primary_10_3390_antiox13101233 crossref_primary_10_3390_cimb47070530 crossref_primary_10_1016_j_ajcnut_2023_09_017 crossref_primary_10_3390_antiox14040482 crossref_primary_10_1186_s13395_023_00326_y crossref_primary_10_1097_FJC_0000000000001564 crossref_primary_10_3389_fendo_2023_1139157 crossref_primary_10_7759_cureus_72414 crossref_primary_10_1016_j_jep_2022_115788 crossref_primary_10_1007_s11886_024_02129_z crossref_primary_10_3390_ijms232012289 crossref_primary_10_1002_efd2_137 crossref_primary_10_1016_j_fbio_2023_103406 crossref_primary_10_1515_ntrev_2023_0205 crossref_primary_10_1186_s13098_025_01699_4 crossref_primary_10_3390_ijms241612812 crossref_primary_10_3389_fendo_2022_1061507 crossref_primary_10_1016_j_heliyon_2024_e25911 crossref_primary_10_3390_plants13020191 crossref_primary_10_3390_ph16121717 crossref_primary_10_1007_s40618_023_02144_x crossref_primary_10_1016_j_bcp_2025_117205 crossref_primary_10_1016_j_tifs_2023_104129 crossref_primary_10_1016_j_mehy_2023_111086 crossref_primary_10_1016_j_trac_2023_117042 crossref_primary_10_3390_diagnostics14242895 crossref_primary_10_3390_ijms24097701 crossref_primary_10_3390_jcdd12030089 crossref_primary_10_3390_healthcare13030233 crossref_primary_10_3390_ijms241713541 crossref_primary_10_7759_cureus_28762 crossref_primary_10_3390_medicina59010182 crossref_primary_10_3390_medicina60050775 crossref_primary_10_1016_j_ultrasmedbio_2025_06_016 crossref_primary_10_1016_j_metabol_2024_155917 crossref_primary_10_3390_life12040564 crossref_primary_10_1016_j_lfs_2022_120725 crossref_primary_10_3390_antibiotics14010036 crossref_primary_10_2147_NDT_S392672 crossref_primary_10_3390_foods12234373 crossref_primary_10_3390_ph15050639 crossref_primary_10_1007_s11033_024_09387_8 crossref_primary_10_3390_foods14132402 crossref_primary_10_7759_cureus_67080 crossref_primary_10_3390_cells12030460 crossref_primary_10_3390_nu16183074 crossref_primary_10_1016_j_ijbiomac_2024_135761 crossref_primary_10_1016_j_prenap_2024_100108 crossref_primary_10_1016_j_drudis_2024_103921 crossref_primary_10_1016_j_molliq_2025_128024 crossref_primary_10_3390_electronics14132583 crossref_primary_10_1136_bjsports_2023_107336 crossref_primary_10_3389_fendo_2023_1164112 crossref_primary_10_36303_SAPJ_2299 crossref_primary_10_1002_cbdv_202401021 crossref_primary_10_1007_s00259_025_07337_5 crossref_primary_10_31083_j_fbs1601005 crossref_primary_10_1016_j_fbio_2024_105110 crossref_primary_10_3390_antiox11122500 crossref_primary_10_3390_ijerph19159398 crossref_primary_10_1016_j_pharma_2023_09_002 crossref_primary_10_3390_ijms252312784 crossref_primary_10_1210_endrev_bnaf017 crossref_primary_10_1038_s41598_023_50395_8 crossref_primary_10_2147_CIA_S414620 crossref_primary_10_7759_cureus_91259 crossref_primary_10_26641_2307_0404_2023_1_276010 crossref_primary_10_1007_s12247_025_10064_x crossref_primary_10_1186_s13287_023_03537_8 crossref_primary_10_1016_j_cellsig_2023_110999 crossref_primary_10_3390_metabo15060395 crossref_primary_10_3389_fnut_2023_1143682 crossref_primary_10_1016_j_jcjd_2024_04_011 crossref_primary_10_1080_1062936X_2024_2366886 crossref_primary_10_2147_JMDH_S529217 crossref_primary_10_1080_10826076_2023_2284737 crossref_primary_10_1371_journal_pone_0302912 crossref_primary_10_1111_dom_70133 crossref_primary_10_1002_edm2_511 crossref_primary_10_3389_fcell_2024_1500394 crossref_primary_10_1186_s12920_023_01575_y crossref_primary_10_3389_froh_2025_1468995 crossref_primary_10_3390_ijms24010616 crossref_primary_10_3389_fendo_2025_1537303 crossref_primary_10_3390_ijms25010028 crossref_primary_10_1155_2024_9532236 crossref_primary_10_2147_DDDT_S459931 crossref_primary_10_1891_JDNP_2021_0046 crossref_primary_10_1186_s12967_023_04026_5 crossref_primary_10_1016_j_numecd_2023_07_004 crossref_primary_10_1038_s41598_023_49274_z crossref_primary_10_1016_j_bone_2021_116292 crossref_primary_10_29328_journal_acgh_1001050 crossref_primary_10_52711_0974_360X_2025_00075 crossref_primary_10_1016_j_ijbiomac_2024_134993 crossref_primary_10_1007_s11010_023_04696_1 crossref_primary_10_2147_DMSO_S389889 crossref_primary_10_3389_fendo_2025_1641318 crossref_primary_10_1186_s12920_023_01477_z crossref_primary_10_3389_fimmu_2023_1028303 crossref_primary_10_1016_j_bcp_2023_115723 crossref_primary_10_1186_s12906_025_04845_7 crossref_primary_10_3390_jcm13237443 crossref_primary_10_4239_wjd_v15_i2_142 crossref_primary_10_1007_s40139_022_00229_5 crossref_primary_10_1016_j_bioorg_2025_108696 crossref_primary_10_1016_j_gene_2025_149748 crossref_primary_10_3390_ijms22169059 crossref_primary_10_4093_dmj_2025_0675 crossref_primary_10_2174_0115734110304322240430053410 crossref_primary_10_3390_nu14163324 crossref_primary_10_1371_journal_pone_0313627 crossref_primary_10_3390_dj13030100 crossref_primary_10_1016_j_imbio_2025_153113 crossref_primary_10_1038_s41420_025_02672_w crossref_primary_10_3389_fendo_2021_738427 crossref_primary_10_1016_j_ijbiomac_2025_140221 crossref_primary_10_3390_molecules27061904 crossref_primary_10_4239_wjd_v15_i2_154 crossref_primary_10_1210_clinem_dgae736 crossref_primary_10_1016_j_clnesp_2023_08_034 crossref_primary_10_1016_j_lfs_2021_120039 crossref_primary_10_3390_ijms23063326 crossref_primary_10_7759_cureus_23119 crossref_primary_10_1016_j_jiph_2022_03_002 crossref_primary_10_1007_s12035_025_05051_9 crossref_primary_10_1016_j_ijgfs_2023_100706 crossref_primary_10_1016_j_reprotox_2021_10_008 crossref_primary_10_2337_dc23_0978 crossref_primary_10_2147_DDDT_S525690 crossref_primary_10_1007_s11302_024_10006_1 crossref_primary_10_58545_jrcnp_v3i1_462 crossref_primary_10_1080_02652048_2022_2149967 crossref_primary_10_3389_fimmu_2025_1574157 crossref_primary_10_1016_j_tiv_2024_105975 crossref_primary_10_3390_healthcare12151528 crossref_primary_10_1016_j_ecl_2024_10_004 crossref_primary_10_1016_j_lfs_2023_121935 crossref_primary_10_1016_j_phymed_2025_157214 crossref_primary_10_2478_fzm_2022_0030 crossref_primary_10_3390_cimb46100648 crossref_primary_10_7759_cureus_47525 crossref_primary_10_14411_fp_2025_024 crossref_primary_10_3390_medicina58070876 crossref_primary_10_1016_j_foodres_2021_110208 crossref_primary_10_1186_s41110_024_00304_4 crossref_primary_10_3389_fmed_2025_1646495 crossref_primary_10_3390_biom12121755 crossref_primary_10_1016_j_biopha_2024_116755 crossref_primary_10_1016_j_cellsig_2024_111291 crossref_primary_10_3389_fendo_2023_1243132 crossref_primary_10_3390_ijms23084228 crossref_primary_10_3390_nu14030668 crossref_primary_10_1016_j_ijbiomac_2025_140212 crossref_primary_10_36303_SAPJ_1000 crossref_primary_10_3390_ph16121692 crossref_primary_10_1002_slct_202404445 crossref_primary_10_2174_0115680266356941250329172041 crossref_primary_10_1186_s12933_025_02798_2 crossref_primary_10_3389_fphar_2025_1595323 crossref_primary_10_1186_s12906_025_04974_z crossref_primary_10_4239_wjd_v15_i4_638 crossref_primary_10_1016_j_fbio_2023_103050 crossref_primary_10_3389_fgene_2022_1008511 crossref_primary_10_47419_bjbabs_v4i02_178 crossref_primary_10_1371_journal_pone_0304708 crossref_primary_10_1055_s_0044_1787848 crossref_primary_10_1155_2023_4024877 crossref_primary_10_1038_s41598_025_06290_5 crossref_primary_10_52711_0974_360X_2025_00014 crossref_primary_10_1096_fj_202402008R crossref_primary_10_3390_life15060936 crossref_primary_10_3390_stresses3040052 crossref_primary_10_1007_s11468_025_03010_7 crossref_primary_10_1007_s11220_024_00511_3 crossref_primary_10_3389_fnut_2023_1298046 crossref_primary_10_14710_jekk_v10i3_25567 crossref_primary_10_1186_s43162_025_00499_6 crossref_primary_10_1177_19322968251315497 crossref_primary_10_2174_0115733998322754240802063730 crossref_primary_10_1002_cbf_4131 crossref_primary_10_1016_j_sjbs_2023_103579 crossref_primary_10_1016_j_pcd_2025_02_008 crossref_primary_10_1016_j_molcel_2021_08_018 crossref_primary_10_5114_amscd_2022_122272 crossref_primary_10_3389_fphar_2023_1179705 crossref_primary_10_3390_life11101074 crossref_primary_10_1002_mnfr_202300870 crossref_primary_10_3389_fdgth_2024_1336050 crossref_primary_10_3748_wjg_v31_i11_104065 crossref_primary_10_1177_20406223241247650 crossref_primary_10_3390_metabo14070371 crossref_primary_10_1080_10408398_2022_2043821 crossref_primary_10_1016_j_jff_2023_105989 crossref_primary_10_1080_29947677_2025_2539083 crossref_primary_10_1016_j_jep_2024_118516 crossref_primary_10_1038_s41598_021_96796_5 crossref_primary_10_3390_life13112166 crossref_primary_10_33262_anatomiadigital_v8i2_2_3466 crossref_primary_10_3390_ijms23063346 crossref_primary_10_3390_medsci11030050 crossref_primary_10_1093_inthealth_ihae013 crossref_primary_10_1016_j_diabres_2025_112285 crossref_primary_10_3390_cells10071768 crossref_primary_10_1007_s00210_025_04456_6 crossref_primary_10_1016_j_foodres_2025_116587 crossref_primary_10_1002_cbf_4111 crossref_primary_10_1002_jsfa_12488 crossref_primary_10_4155_fmc_2023_0203 crossref_primary_10_1007_s10006_025_01375_x crossref_primary_10_1016_j_diabres_2025_112208 crossref_primary_10_3390_ph15040486 crossref_primary_10_1016_j_nutres_2022_08_002 crossref_primary_10_1016_j_mam_2025_101370 crossref_primary_10_1038_s42003_024_06333_z crossref_primary_10_3390_molecules30153096 crossref_primary_10_3389_fendo_2025_1617248 crossref_primary_10_1038_s41598_023_45357_z crossref_primary_10_7759_cureus_67995 crossref_primary_10_1016_j_heliyon_2022_e11529 crossref_primary_10_1016_j_jsps_2024_102026 crossref_primary_10_2147_DMSO_S481690 crossref_primary_10_1016_j_artere_2025_100724 crossref_primary_10_1007_s13300_024_01609_3 crossref_primary_10_1016_j_jsps_2024_102029 crossref_primary_10_3390_jcm13020561 crossref_primary_10_1016_j_advnut_2023_08_006 crossref_primary_10_1002_ptr_7918 crossref_primary_10_3389_fendo_2025_1570332 crossref_primary_10_3390_cells11081367 crossref_primary_10_3390_foods13020241 crossref_primary_10_1089_tmr_2024_0003 crossref_primary_10_1016_j_mam_2025_101381 crossref_primary_10_3390_metabo14120672 crossref_primary_10_2174_011871529X356362250324080014 crossref_primary_10_1186_s12872_025_04745_1 crossref_primary_10_1038_s41598_024_68176_2 crossref_primary_10_2174_0113816128313325240513113840 crossref_primary_10_1016_j_gene_2024_149050 crossref_primary_10_3390_molecules29020305 crossref_primary_10_3390_antiox12061309 crossref_primary_10_3389_fendo_2024_1313597 crossref_primary_10_1186_s12933_025_02861_y crossref_primary_10_3390_ijms26178159 crossref_primary_10_3390_antiox12040863 crossref_primary_10_52711_0974_360X_2025_00458 crossref_primary_10_54691_7r1a1m23 crossref_primary_10_3389_fchem_2024_1458505 crossref_primary_10_3390_nu16172847 crossref_primary_10_1007_s11030_022_10571_w crossref_primary_10_1007_s40200_025_01632_6 crossref_primary_10_4239_wjd_v14_i11_1603 crossref_primary_10_1096_fj_202401464R crossref_primary_10_1111_ors_12821 crossref_primary_10_1016_j_phyplu_2025_100777 crossref_primary_10_1155_2022_6852276 crossref_primary_10_1007_s42485_025_00179_7 crossref_primary_10_1016_j_phanu_2023_100352 crossref_primary_10_1016_j_apsb_2022_11_008 crossref_primary_10_1007_s12020_024_04154_y crossref_primary_10_1007_s12247_025_10046_z crossref_primary_10_1186_s12902_024_01782_3 crossref_primary_10_3389_fphar_2021_716517 crossref_primary_10_3390_molecules29215018 crossref_primary_10_1016_j_ctcp_2023_101802 crossref_primary_10_3390_biomedicines12040866 crossref_primary_10_3390_nu15102355 crossref_primary_10_1155_2024_9097238 crossref_primary_10_1016_j_heliyon_2024_e25499 crossref_primary_10_3390_jcm13206126 crossref_primary_10_1111_wrr_13239 crossref_primary_10_1055_s_0041_1740150 crossref_primary_10_1007_s11033_023_08574_3 crossref_primary_10_3390_diagnostics13142436 crossref_primary_10_1097_CRD_0000000000000940 crossref_primary_10_3390_biom14030310 crossref_primary_10_1007_s40519_024_01647_7 crossref_primary_10_3389_fnut_2022_1070908 crossref_primary_10_1016_j_diabres_2024_111958 crossref_primary_10_2337_db24_0419 crossref_primary_10_3390_nu15184037 crossref_primary_10_1007_s12672_025_03264_x crossref_primary_10_1016_j_molstruc_2024_140288 crossref_primary_10_1016_j_clnu_2024_01_011 crossref_primary_10_1007_s11356_021_17346_0 crossref_primary_10_4239_wjd_v14_i1_35 crossref_primary_10_3389_fphar_2023_1184572 crossref_primary_10_3390_molecules27103135 crossref_primary_10_1111_myc_13753 crossref_primary_10_3390_microorganisms13010161 crossref_primary_10_3390_children12091263 crossref_primary_10_70749_ijbr_v3i1_425 crossref_primary_10_3389_fphar_2022_828473 crossref_primary_10_1111_iwj_14411 crossref_primary_10_1039_D3FO05439J crossref_primary_10_1016_j_envint_2024_108711 crossref_primary_10_1002_mco2_70359 crossref_primary_10_3390_ijms24119765 crossref_primary_10_1016_j_molmet_2023_101752 crossref_primary_10_1186_s13098_024_01369_x crossref_primary_10_3390_polym16131825 crossref_primary_10_1007_s12038_025_00551_1 crossref_primary_10_3390_j6040040 crossref_primary_10_4103_pm_pm_179_21 crossref_primary_10_3390_biomedicines10030643 crossref_primary_10_1007_s13410_024_01350_4 crossref_primary_10_1016_j_ejmech_2021_113720 crossref_primary_10_1016_j_cbpc_2024_109976 crossref_primary_10_3390_ijerph19106084 crossref_primary_10_3389_fimmu_2022_814203 crossref_primary_10_1002_mnfr_202300468 crossref_primary_10_25259_IJPP_257_2024 crossref_primary_10_3390_antiox13030277 crossref_primary_10_1093_chromsci_bmaf019 crossref_primary_10_1002_pmic_70000 crossref_primary_10_1053_j_jrn_2023_05_006 crossref_primary_10_3390_metabo13010060 crossref_primary_10_1016_j_biopha_2021_112094 crossref_primary_10_3390_nu16213597 crossref_primary_10_1016_j_microc_2025_114792 crossref_primary_10_3390_life13071473 crossref_primary_10_4239_wjd_v14_i1_26 crossref_primary_10_3390_life13091905 crossref_primary_10_1016_j_yexmp_2022_104763 crossref_primary_10_7759_cureus_44908 crossref_primary_10_1371_journal_pone_0305604 crossref_primary_10_1007_s12011_022_03140_7 crossref_primary_10_3390_jcm13133910 crossref_primary_10_62347_GMTV5559 crossref_primary_10_1007_s11306_023_02066_y crossref_primary_10_3390_ijerph20043729 crossref_primary_10_1016_j_jdiacomp_2022_108266 crossref_primary_10_3390_life15060873 crossref_primary_10_1007_s00592_021_01843_2 crossref_primary_10_3390_molecules27082393 crossref_primary_10_1177_09603271221126487 crossref_primary_10_3390_ijms24087630 crossref_primary_10_1186_s12967_025_06720_y crossref_primary_10_1016_j_heliyon_2024_e32198 crossref_primary_10_1007_s13300_022_01312_1 crossref_primary_10_1007_s13300_024_01617_3 crossref_primary_10_3390_ijms23147751 crossref_primary_10_1038_s41598_024_53213_x crossref_primary_10_1088_1755_1315_1492_1_012004 crossref_primary_10_1016_j_humgen_2025_201386 crossref_primary_10_1016_j_jff_2024_106271 crossref_primary_10_1089_adt_2024_029 crossref_primary_10_1016_j_jdiacomp_2023_108564 crossref_primary_10_1136_bmjdrc_2024_004191 crossref_primary_10_3390_ijms252010960 crossref_primary_10_3390_nu17020292 crossref_primary_10_54133_ajms_v9i1_2339 crossref_primary_10_1007_s12011_023_03695_z crossref_primary_10_1186_s12933_024_02410_z crossref_primary_10_1210_endocr_bqac118 crossref_primary_10_1007_s12010_024_05092_1 crossref_primary_10_1007_s40200_021_00908_x crossref_primary_10_3390_jcm12237260 crossref_primary_10_2147_JIR_S528826 crossref_primary_10_3390_ijms26010354 crossref_primary_10_1080_08870446_2025_2546411 crossref_primary_10_1016_j_jff_2024_106261 crossref_primary_10_1016_j_tifs_2022_10_008 crossref_primary_10_3390_molecules27072102 crossref_primary_10_3389_fphar_2025_1534634 crossref_primary_10_3390_cimb47080630 crossref_primary_10_1016_j_cca_2024_117857 crossref_primary_10_3390_separations10080442 crossref_primary_10_3389_fphar_2024_1457383 crossref_primary_10_1186_s12887_023_03983_6 crossref_primary_10_1016_j_numecd_2022_02_004 crossref_primary_10_3390_cells12030513 crossref_primary_10_1007_s12079_023_00735_0 crossref_primary_10_3390_foods12203738 crossref_primary_10_1016_j_molstruc_2024_139207 crossref_primary_10_1097_MCO_0000000000001070 crossref_primary_10_1111_bph_16485 crossref_primary_10_7759_cureus_65808 crossref_primary_10_7759_cureus_93035 crossref_primary_10_1039_D2FO02373C crossref_primary_10_1002_ptr_8026 crossref_primary_10_1016_j_molstruc_2024_138359 crossref_primary_10_4103_RPS_RPS_94_24 crossref_primary_10_1210_jendso_bvac184 crossref_primary_10_1186_s13098_024_01423_8 crossref_primary_10_1016_j_etap_2022_104046 crossref_primary_10_1111_iwj_14488 crossref_primary_10_20473_amnt_v9i1_2025_64_75 crossref_primary_10_1016_j_ymeth_2025_01_003 crossref_primary_10_1055_a_2604_4115 crossref_primary_10_1007_s40203_024_00260_x crossref_primary_10_3389_fphys_2022_1037750 crossref_primary_10_1002_ardp_70033 crossref_primary_10_1002_bab_70031 crossref_primary_10_3390_sports12010003 crossref_primary_10_1016_j_tjnut_2023_08_023 crossref_primary_10_1016_j_numecd_2022_04_019 crossref_primary_10_1016_j_jpsychores_2023_111445 crossref_primary_10_1016_j_puhe_2023_11_012 crossref_primary_10_4103_jasmr_jasmr_23_23 crossref_primary_10_1155_2024_9974083 crossref_primary_10_1002_hsr2_70935 crossref_primary_10_3390_molecules27061838 crossref_primary_10_1177_20417314241253290 crossref_primary_10_3390_foods10112528 crossref_primary_10_1371_journal_pone_0312356 crossref_primary_10_1080_15438627_2024_2349521 crossref_primary_10_22141_2307_1257_14_2_2025_522 crossref_primary_10_1016_j_clinbiomech_2023_106126 crossref_primary_10_1016_j_steroids_2025_109685 crossref_primary_10_3389_fnut_2025_1582495 crossref_primary_10_1016_j_mehy_2022_110804 crossref_primary_10_1007_s42452_025_07588_9 crossref_primary_10_1016_j_bcab_2024_103176 crossref_primary_10_1016_j_brainres_2025_149586 crossref_primary_10_1007_s10557_025_07690_5 crossref_primary_10_26599_FMH_2025_9420068 crossref_primary_10_3390_healthcare12080848 crossref_primary_10_3746_pnf_2025_30_2_120 crossref_primary_10_3389_fendo_2023_1223583 crossref_primary_10_3390_cells12071054 crossref_primary_10_1016_j_eprac_2024_11_013 crossref_primary_10_1016_j_biopha_2023_115287 crossref_primary_10_3390_healthcare11040485 crossref_primary_10_22159_ajpcr_2025v18i6_54549 crossref_primary_10_12998_wjcc_v12_i17_2966 crossref_primary_10_1016_j_numecd_2025_103963 crossref_primary_10_1177_20420188251362091 crossref_primary_10_1111_jfbc_14360 crossref_primary_10_7759_cureus_74769 crossref_primary_10_1016_j_ijheh_2023_114124 crossref_primary_10_1016_j_bcp_2024_116399 crossref_primary_10_4239_wjd_v15_i10_2152 crossref_primary_10_1002_puh2_70011 crossref_primary_10_1038_s41574_022_00671_w crossref_primary_10_3390_s22072787 crossref_primary_10_1186_s40795_025_01005_5 crossref_primary_10_1039_D4MD00344F crossref_primary_10_3390_nu16060756 crossref_primary_10_1007_s12602_024_10377_2 crossref_primary_10_1186_s40795_023_00803_z crossref_primary_10_1016_j_brainres_2024_149241 crossref_primary_10_7759_cureus_59561 crossref_primary_10_3390_diagnostics14242769 crossref_primary_10_1021_acs_jafc_4c03987 crossref_primary_10_1016_j_drugalcdep_2023_111066 crossref_primary_10_3390_diagnostics13122035 crossref_primary_10_1002_fsn3_70076 crossref_primary_10_1039_D3FO04103D crossref_primary_10_1136_bmjopen_2023_075607 crossref_primary_10_3390_molecules30071460 crossref_primary_10_1055_a_2407_9360 crossref_primary_10_3390_md21040222 crossref_primary_10_3390_molecules29235775 crossref_primary_10_5937_arhfarm72_36386 crossref_primary_10_1007_s00217_025_04869_w crossref_primary_10_1007_s00592_022_01918_8 crossref_primary_10_1038_s41467_022_31317_0 crossref_primary_10_2147_DMSO_S291932 crossref_primary_10_3389_fendo_2025_1624472 crossref_primary_10_3390_biomedicines10020481 crossref_primary_10_1039_D4FO04316B crossref_primary_10_1016_j_dsx_2025_103185 crossref_primary_10_3389_fnut_2022_940673 crossref_primary_10_3390_medicina61040613 crossref_primary_10_1016_j_coph_2021_11_010 crossref_primary_10_3390_cells11030491 crossref_primary_10_3390_nu16244260 crossref_primary_10_1007_s00125_024_06204_6 crossref_primary_10_1177_00368504251338631 crossref_primary_10_1016_j_heares_2024_109072 crossref_primary_10_1016_j_humgen_2023_201177 crossref_primary_10_1186_s43042_025_00682_y crossref_primary_10_17352_2455_8583_000067 crossref_primary_10_22141_2224_0721_21_4_2025_1563 crossref_primary_10_1016_j_biopha_2022_113600 crossref_primary_10_1016_j_pcd_2025_06_007 crossref_primary_10_22159_ijap_2025v17i5_54818 crossref_primary_10_1016_j_jnutbio_2023_109404 crossref_primary_10_1002_ardp_202300569 crossref_primary_10_1016_j_jnutbio_2023_109401 crossref_primary_10_3389_fnut_2022_892426 crossref_primary_10_7759_cureus_60572 crossref_primary_10_2147_DMSO_S545571 crossref_primary_10_5114_bta_207911 crossref_primary_10_3389_fendo_2025_1547920 crossref_primary_10_1002_btpr_3529 crossref_primary_10_2174_0115748855292471240319055530 crossref_primary_10_3390_brainsci15090952 crossref_primary_10_3390_nu16010172 crossref_primary_10_3390_ijms231910988 crossref_primary_10_1177_87564793231156384 crossref_primary_10_1186_s12872_022_02637_2 crossref_primary_10_1186_s13578_023_00966_z crossref_primary_10_1007_s40200_022_01175_0 crossref_primary_10_1155_genr_8818420 crossref_primary_10_1111_cts_13566 crossref_primary_10_20960_nh_03838 crossref_primary_10_1016_j_colsurfb_2024_113761 crossref_primary_10_1080_10715762_2022_2133705 crossref_primary_10_1016_j_amolm_2025_100081 crossref_primary_10_1016_j_procbio_2024_09_001 crossref_primary_10_3390_foods14172937 crossref_primary_10_1016_j_metabol_2022_155264 crossref_primary_10_1016_j_saa_2024_125630 crossref_primary_10_1900_RDS_2023_19_14 crossref_primary_10_1007_s10068_024_01775_x crossref_primary_10_1186_s13036_024_00457_w crossref_primary_10_4103_jmh_jmh_75_25 crossref_primary_10_3390_foods11192961 crossref_primary_10_1016_j_bpc_2023_107130 crossref_primary_10_1016_j_genrep_2024_102019 crossref_primary_10_1016_j_fbio_2024_105257 crossref_primary_10_1002_cbdv_202402258 crossref_primary_10_1111_jcmm_16663 crossref_primary_10_3390_ijms24043219 crossref_primary_10_7759_cureus_89044 crossref_primary_10_1186_s12902_021_00927_y crossref_primary_10_3389_fendo_2024_1431405 crossref_primary_10_1007_s11596_025_00010_w crossref_primary_10_3389_fnut_2025_1629154 crossref_primary_10_2337_ds24_0048 crossref_primary_10_3389_fendo_2024_1377918 crossref_primary_10_3390_nu15245060 crossref_primary_10_1186_s10020_024_00824_9 crossref_primary_10_3390_ph18071035 crossref_primary_10_1016_j_toxicon_2024_107724 crossref_primary_10_1155_2021_4791915 crossref_primary_10_7759_cureus_57494 crossref_primary_10_1002_jcb_30655 crossref_primary_10_1016_j_jamda_2024_03_110 crossref_primary_10_3892_etm_2024_12680 crossref_primary_10_1002_ptr_8517 crossref_primary_10_3390_biom13101544 crossref_primary_10_1016_j_sajb_2025_03_047 crossref_primary_10_1080_13813455_2022_2108454 crossref_primary_10_1186_s12964_024_01526_9 crossref_primary_10_1038_s41598_023_34072_4 crossref_primary_10_61186_rbmb_11_2_299 crossref_primary_10_1016_j_lfs_2024_122449 crossref_primary_10_1038_s41598_023_50844_4 crossref_primary_10_7759_cureus_65050 crossref_primary_10_1016_j_bbrc_2024_150316 crossref_primary_10_1016_j_talanta_2022_124130 crossref_primary_10_1007_s40200_025_01604_w crossref_primary_10_2147_DDDT_S487469 crossref_primary_10_3389_fphar_2022_916603 crossref_primary_10_1016_j_imu_2024_101509 crossref_primary_10_1186_s13073_023_01255_7 crossref_primary_10_3390_nu16071015 crossref_primary_10_1002_path_5777 crossref_primary_10_1016_j_drudis_2023_103571 crossref_primary_10_1186_s13063_023_07085_7 crossref_primary_10_3390_md20120777 crossref_primary_10_3390_nu14091918 crossref_primary_10_3390_ijms24043250 crossref_primary_10_3390_nu16121819 crossref_primary_10_5812_jrps_147340 crossref_primary_10_1001_jamanetworkopen_2024_62185 crossref_primary_10_1111_jdi_13775 crossref_primary_10_3390_ijms23020956 crossref_primary_10_1039_D3FO00355H crossref_primary_10_3389_fpubh_2023_1128617 crossref_primary_10_20473_ijph_v18i3_2023_540_551 crossref_primary_10_3390_antiox10060989 crossref_primary_10_1016_j_burns_2024_01_008 crossref_primary_10_1016_j_cmet_2023_09_013 crossref_primary_10_1002_adtp_202300216 crossref_primary_10_1016_j_biocel_2024_106665 crossref_primary_10_3390_ijms23020963 crossref_primary_10_1089_dia_2021_0277 crossref_primary_10_1016_j_imu_2023_101202 crossref_primary_10_3389_fnut_2024_1455236 crossref_primary_10_3389_fphar_2023_1322148 crossref_primary_10_3390_molecules29122747 crossref_primary_10_1111_dme_15369 crossref_primary_10_38124_ijisrt_25jul885 crossref_primary_10_1007_s12010_024_04870_1 crossref_primary_10_3389_fendo_2024_1375771 crossref_primary_10_1002_psp4_12956 crossref_primary_10_1016_j_heares_2025_109412 crossref_primary_10_4103_1673_5374_369095 crossref_primary_10_1093_nar_gkad393 crossref_primary_10_7759_cureus_71730 crossref_primary_10_2147_DMSO_S317659 crossref_primary_10_1080_07391102_2023_2278082 crossref_primary_10_3390_app13116605 crossref_primary_10_3390_ijms24054394 crossref_primary_10_1016_j_bioorg_2023_106826 crossref_primary_10_1016_j_chom_2024_07_017 crossref_primary_10_33393_dti_2025_3271 crossref_primary_10_1016_j_compbiomed_2025_109755 crossref_primary_10_3389_fmed_2025_1579562 crossref_primary_10_1016_j_cbi_2025_111717 crossref_primary_10_7759_cureus_23612 crossref_primary_10_1016_j_biopha_2023_114779 crossref_primary_10_3390_ijms24087659 crossref_primary_10_1016_j_compbiolchem_2024_108059 crossref_primary_10_3389_fcdhc_2025_1495849 crossref_primary_10_1007_s00580_023_03436_7 crossref_primary_10_2174_0115701646323264240821072359 crossref_primary_10_3390_biomedicines11123302 crossref_primary_10_1136_bmjph_2025_002895 crossref_primary_10_3390_ijms26125517 crossref_primary_10_3389_fnut_2024_1375179 crossref_primary_10_1002_hsr2_70495 crossref_primary_10_3389_fnut_2024_1400580 crossref_primary_10_3390_pr12112488 crossref_primary_10_3390_ijms25010342 crossref_primary_10_1111_eci_70003 crossref_primary_10_1016_j_diabres_2025_112380 crossref_primary_10_3390_nu13041228 crossref_primary_10_1111_dom_15491 crossref_primary_10_2147_CIA_S503980 crossref_primary_10_1016_j_heliyon_2024_e37325 crossref_primary_10_1097_JCN_0000000000001167 crossref_primary_10_3389_fimmu_2025_1603484 crossref_primary_10_1016_j_fbio_2023_103195 crossref_primary_10_1155_2022_9611509 crossref_primary_10_1080_00498254_2025_2564120 crossref_primary_10_3390_cancers15225466 crossref_primary_10_1016_j_bioorg_2024_107106 crossref_primary_10_1016_j_heliyon_2024_e38625 crossref_primary_10_1007_s42535_025_01215_z crossref_primary_10_4239_wjd_v14_i5_606 crossref_primary_10_1016_j_isci_2024_111477 crossref_primary_10_3389_fbioe_2022_825046 crossref_primary_10_3389_fphar_2022_1066279 crossref_primary_10_7759_cureus_77004 crossref_primary_10_1016_j_bbi_2025_03_015 crossref_primary_10_1016_j_intimp_2025_115467 crossref_primary_10_3390_jpm13081270 crossref_primary_10_1242_dev_201097 crossref_primary_10_1016_j_afres_2025_101097 crossref_primary_10_3390_ijms26052153 crossref_primary_10_1007_s40200_022_01068_2 crossref_primary_10_1080_03007995_2024_2422005 crossref_primary_10_1007_s42535_022_00487_z crossref_primary_10_3390_antiox14070767 crossref_primary_10_1016_j_job_2025_100646 crossref_primary_10_3390_nu14020396 crossref_primary_10_3390_gidisord6010013 crossref_primary_10_1093_stmcls_sxad021 crossref_primary_10_3390_molecules30051068 crossref_primary_10_1186_s40001_023_01254_9 crossref_primary_10_1007_s11010_025_05306_y crossref_primary_10_1016_j_ultrasmedbio_2024_09_011 crossref_primary_10_1016_j_eprac_2021_04_002 crossref_primary_10_1021_acs_jchemed_4c00285 crossref_primary_10_1021_acsomega_5c03465 crossref_primary_10_4081_hls_2024_12929 crossref_primary_10_1111_iwj_14841 crossref_primary_10_2903_sp_efsa_2024_EN_8661 crossref_primary_10_1109_JSEN_2024_3517472 crossref_primary_10_3390_ijms26104619 crossref_primary_10_12944_CRNFSJ_13_2_12 crossref_primary_10_3390_nu13020351 crossref_primary_10_1080_13543776_2024_2379929 crossref_primary_10_3390_ijms26125544 crossref_primary_10_3390_molecules30091933 crossref_primary_10_3390_ijms24054319 crossref_primary_10_3389_fendo_2021_678055 crossref_primary_10_3390_ijms252212276 crossref_primary_10_3390_jcm12020487 crossref_primary_10_1007_s13668_025_00691_8 crossref_primary_10_70749_ijbr_v3i2_337 crossref_primary_10_3390_ijms24087676 crossref_primary_10_1080_14756366_2025_2497486 crossref_primary_10_3390_nu15112497 crossref_primary_10_1002_slct_202400191 crossref_primary_10_3390_nu14051083 crossref_primary_10_3389_fimmu_2025_1565158 crossref_primary_10_1080_09603123_2024_2391993 crossref_primary_10_1111_dom_16351 crossref_primary_10_1080_07853890_2025_2536204 crossref_primary_10_3390_diagnostics15162110 crossref_primary_10_3390_ijms26157568 crossref_primary_10_3390_foods12051079 crossref_primary_10_1016_j_ijbiomac_2022_01_152 crossref_primary_10_3390_biom14070836 crossref_primary_10_1186_s13098_023_01202_x crossref_primary_10_1080_01913123_2025_2550634 crossref_primary_10_1016_j_eujim_2021_101377 crossref_primary_10_1098_rsos_240543 crossref_primary_10_3390_nu16111669 crossref_primary_10_1002_fsn3_70146 crossref_primary_10_1016_j_jbc_2021_101484 crossref_primary_10_1002_ardp_202200421 crossref_primary_10_3390_biomedicines12071390 crossref_primary_10_1016_j_mce_2024_112387 crossref_primary_10_1038_s43587_024_00597_0 crossref_primary_10_3390_biom14121572 crossref_primary_10_1016_j_stlm_2021_100043 crossref_primary_10_1111_iej_14181 crossref_primary_10_1016_j_cdc_2024_101133 crossref_primary_10_1177_2515690X251345730 crossref_primary_10_3390_molecules29071640 crossref_primary_10_1007_s11033_025_11040_x crossref_primary_10_7759_cureus_89514 crossref_primary_10_3390_plants11101360 crossref_primary_10_1016_j_ctim_2024_103014 crossref_primary_10_1371_journal_pone_0303569 crossref_primary_10_15212_bioi_2024_0005 crossref_primary_10_1155_2022_5868682 crossref_primary_10_7717_peerj_17630 crossref_primary_10_1080_13813455_2025_2459865 crossref_primary_10_1016_j_heliyon_2024_e32007 crossref_primary_10_3390_ijms23063068 crossref_primary_10_3390_ijms26010037 crossref_primary_10_52711_0974_360X_2023_00673 crossref_primary_10_1080_15376516_2025_2544030 crossref_primary_10_7717_peerj_16778 crossref_primary_10_1136_bmjdrc_2023_003966 crossref_primary_10_3390_ijms25031517 crossref_primary_10_1007_s40200_022_01038_8 crossref_primary_10_1111_acel_70084 crossref_primary_10_1016_j_pop_2021_11_009 crossref_primary_10_1007_s00394_024_03575_9 crossref_primary_10_1039_D5RA01835H crossref_primary_10_1159_000520263 crossref_primary_10_1371_journal_pone_0320948 crossref_primary_10_3390_life15081241 crossref_primary_10_1016_j_brainres_2025_149625 crossref_primary_10_7759_cureus_65545 crossref_primary_10_1016_j_amepre_2024_12_002 crossref_primary_10_1016_j_obmed_2025_100611 crossref_primary_10_1016_j_jinorgbio_2021_111585 crossref_primary_10_7748_ns_2025_e12429 crossref_primary_10_1016_j_prenap_2023_100004 crossref_primary_10_1080_0886022X_2023_2183726 crossref_primary_10_3389_fnut_2022_981200 crossref_primary_10_1039_D4FO01870B crossref_primary_10_2217_rme_2023_0193 crossref_primary_10_1016_j_ijbiomac_2024_136489 crossref_primary_10_1007_s13410_025_01548_0 crossref_primary_10_1016_j_bbadis_2023_166726 crossref_primary_10_1007_s11427_024_2695_x crossref_primary_10_1016_j_amolm_2024_100046 crossref_primary_10_1016_j_phytol_2022_02_009 crossref_primary_10_23736_S0031_0808_25_05314_5 crossref_primary_10_4103_jfmpc_jfmpc_1803_24 crossref_primary_10_1016_j_jksus_2022_101827 crossref_primary_10_1038_s41598_025_07272_3 crossref_primary_10_3389_fnut_2022_878665 crossref_primary_10_18502_kls_v9i1_19353 crossref_primary_10_3390_ph18060913 crossref_primary_10_3390_ph17070929 crossref_primary_10_61186_jbrms_12_1_34 crossref_primary_10_1007_s12011_025_04566_5 crossref_primary_10_3389_fimmu_2023_1221609 crossref_primary_10_1371_journal_pone_0329301 crossref_primary_10_1371_journal_pone_0294518 crossref_primary_10_1016_j_amolm_2024_100037 crossref_primary_10_1007_s12602_025_10678_0 crossref_primary_10_1016_j_hnm_2023_200236 crossref_primary_10_1016_j_heliyon_2023_e18725 crossref_primary_10_1016_j_jep_2022_115936 crossref_primary_10_1016_j_ejmech_2024_116728 crossref_primary_10_1007_s13205_022_03309_w crossref_primary_10_5114_reum_189998 crossref_primary_10_7759_cureus_31773 crossref_primary_10_1016_j_optcom_2022_128916 crossref_primary_10_1016_j_biochi_2024_07_004 crossref_primary_10_1016_j_heliyon_2023_e23289 crossref_primary_10_1016_j_fbio_2024_104881 crossref_primary_10_1016_j_bbrc_2025_152234 crossref_primary_10_1016_j_algal_2024_103885 crossref_primary_10_1016_j_molmet_2024_101958 crossref_primary_10_3390_cells13191623 crossref_primary_10_1007_s10557_021_07272_1 crossref_primary_10_4103_jpbs_jpbs_539_25 crossref_primary_10_3390_nu16111691 crossref_primary_10_1038_s12276_023_00958_6 crossref_primary_10_1016_j_fitote_2024_105895 crossref_primary_10_1186_s12944_025_02526_5 crossref_primary_10_4103_jpcs_jpcs_36_25 crossref_primary_10_1002_ppul_25651 crossref_primary_10_3390_biomed2020016 crossref_primary_10_1093_burnst_tkaf053 crossref_primary_10_1007_s40820_025_01843_9 crossref_primary_10_1186_s13098_024_01566_8 crossref_primary_10_1016_j_algal_2024_103414 crossref_primary_10_13005_bpj_3024 crossref_primary_10_3390_plants11101386 crossref_primary_10_1007_s00441_023_03801_6 crossref_primary_10_3390_biomedicines13071610 crossref_primary_10_1080_09205063_2025_2492777 crossref_primary_10_7748_ns_2025_e12464 crossref_primary_10_1080_10408398_2023_2170320 crossref_primary_10_52711_2321_5836_2024_00049 crossref_primary_10_1016_j_bioorg_2025_108922 crossref_primary_10_1016_j_jep_2025_119938 crossref_primary_10_1002_cbf_3943 crossref_primary_10_1016_j_health_2025_100402 crossref_primary_10_7759_cureus_42807 crossref_primary_10_1016_j_jdent_2024_104982 crossref_primary_10_7759_cureus_63744 crossref_primary_10_3389_fendo_2024_1399694 crossref_primary_10_1016_j_bioorg_2025_108498 crossref_primary_10_3390_nu13113972 crossref_primary_10_1016_j_lfs_2023_122124 crossref_primary_10_1177_23971983241301231 crossref_primary_10_1016_j_foohum_2025_100711 crossref_primary_10_3389_fmars_2024_1438955 crossref_primary_10_3390_plants12102014 crossref_primary_10_1088_1755_1315_1174_1_012035 crossref_primary_10_3390_biom14111364 crossref_primary_10_1007_s11831_025_10335_3 crossref_primary_10_1016_j_arr_2023_102018 crossref_primary_10_1016_j_heliyon_2023_e14719 crossref_primary_10_1016_j_dsx_2024_102951 crossref_primary_10_1038_s41598_024_56451_1 crossref_primary_10_4239_wjd_v16_i2_98423 crossref_primary_10_1097_MD_0000000000028823 crossref_primary_10_4103_amsr_amsr_16_24 crossref_primary_10_2174_0115733998320832240805113238 crossref_primary_10_63096_medtigo3061115 crossref_primary_10_1016_j_clnesp_2024_11_011 crossref_primary_10_1016_j_bbamcr_2021_119099 crossref_primary_10_1016_j_sjbs_2021_08_095 crossref_primary_10_3389_fphys_2023_1241096 crossref_primary_10_3389_fendo_2023_1156757 crossref_primary_10_1371_journal_pone_0277127 crossref_primary_10_1016_j_saa_2024_123844 crossref_primary_10_1016_j_phrs_2022_106326 crossref_primary_10_1210_clinem_dgaf460 crossref_primary_10_3390_molecules29122934 crossref_primary_10_1016_j_rechem_2025_102594 crossref_primary_10_1097_JCMA_0000000000001158 crossref_primary_10_1111_dom_15908 crossref_primary_10_3390_nu14050981 crossref_primary_10_24171_j_phrp_2023_0084 crossref_primary_10_2147_DMSO_S473042 crossref_primary_10_3390_nu17152489 crossref_primary_10_1039_D4MD00023D crossref_primary_10_1186_s43094_022_00443_3 crossref_primary_10_3390_molecules26164867 crossref_primary_10_1177_11795514241288645 crossref_primary_10_1016_j_neuropharm_2025_110673 crossref_primary_10_3390_jcm13247866 crossref_primary_10_1007_s43450_023_00363_0 crossref_primary_10_1016_j_jddst_2025_106879 crossref_primary_10_3390_nu16213644 crossref_primary_10_1016_j_jff_2024_106518 crossref_primary_10_7759_cureus_82497 crossref_primary_10_1186_s43088_023_00412_6 crossref_primary_10_59761_RCR5150 crossref_primary_10_1016_j_envres_2023_117776 crossref_primary_10_1038_s41598_025_13946_9 crossref_primary_10_1016_j_tube_2023_102426 crossref_primary_10_1055_a_2239_2668 crossref_primary_10_3390_nu16121837 crossref_primary_10_1186_s12902_024_01637_x crossref_primary_10_3390_molecules26247689 crossref_primary_10_1155_sci5_5516791 crossref_primary_10_1186_s43161_023_00155_6 crossref_primary_10_3389_fnut_2021_741249 crossref_primary_10_3390_toxics11100867 crossref_primary_10_3390_medicina58111605 crossref_primary_10_3390_ijms26030909 crossref_primary_10_4103_JNMO_JNMO_26_25 crossref_primary_10_12677_tcm_2024_138304 crossref_primary_10_3390_children9101572 crossref_primary_10_1111_dme_14905 crossref_primary_10_1016_j_fbio_2025_106499 crossref_primary_10_1016_j_phrs_2022_106358 crossref_primary_10_7759_cureus_48551 crossref_primary_10_3390_metabo12111092 crossref_primary_10_1007_s00253_023_12754_3 crossref_primary_10_1016_j_cmet_2023_03_001 crossref_primary_10_2174_1381612829666230417083133 crossref_primary_10_33483_jfpau_1553867 crossref_primary_10_1007_s42399_023_01563_4 crossref_primary_10_3390_vaccines11071203 crossref_primary_10_3390_molecules29071605 crossref_primary_10_7759_cureus_49896 crossref_primary_10_1007_s42000_024_00566_7 crossref_primary_10_1111_jfbc_14423 crossref_primary_10_1515_znc_2024_0142 crossref_primary_10_1016_j_humgen_2025_201427 crossref_primary_10_12991_jrespharm_1766172 crossref_primary_10_2174_012210299X233215230920151713 crossref_primary_10_1016_j_jddst_2024_106590 crossref_primary_10_1371_journal_pone_0325357 crossref_primary_10_1155_jfbc_8607956 crossref_primary_10_3390_polym14152991 crossref_primary_10_1016_j_heliyon_2023_e16919 crossref_primary_10_1016_j_jddst_2024_106119 crossref_primary_10_3390_ijms25116141 crossref_primary_10_1002_cmdc_202200320 crossref_primary_10_3390_molecules27010182 crossref_primary_10_1080_19490976_2022_2111952 crossref_primary_10_1038_s41598_023_29791_7 crossref_primary_10_1016_j_heliyon_2024_e40074 crossref_primary_10_62347_TKQK8110 crossref_primary_10_1002_slct_202401604 crossref_primary_10_1016_j_diabres_2022_110197 crossref_primary_10_20473_jbe_V13I12025_33_39 crossref_primary_10_1016_j_ejmech_2024_116325 crossref_primary_10_3892_mmr_2022_12894 crossref_primary_10_1016_j_abst_2023_10_001 crossref_primary_10_1038_s41392_025_02166_2 crossref_primary_10_1017_S0007114524001879 crossref_primary_10_3390_biomedicines11112939 crossref_primary_10_1080_07853890_2025_2530694 crossref_primary_10_1186_s12937_025_01184_8 crossref_primary_10_3390_nu15214690 crossref_primary_10_3390_molecules28207209 crossref_primary_10_1177_15533506241229040 crossref_primary_10_3389_fphar_2025_1621414 crossref_primary_10_1016_j_diabres_2023_110905 crossref_primary_10_1007_s11033_025_10673_2 crossref_primary_10_3389_fbioe_2024_1356028 crossref_primary_10_3390_molecules29235689 crossref_primary_10_17533_udea_rfnsp_e356362 crossref_primary_10_1111_obr_13639 crossref_primary_10_3390_ijms26020637 crossref_primary_10_1111_dom_15533 crossref_primary_10_1136_bmjopen_2022_060896 crossref_primary_10_1080_13813455_2023_2283685 crossref_primary_10_1016_j_heliyon_2023_e16031 crossref_primary_10_1002_bab_2756 crossref_primary_10_2144_fsoa_2023_0208 crossref_primary_10_5937_jomb0_39636 crossref_primary_10_3389_fimmu_2025_1506500 crossref_primary_10_4252_wjsc_v15_i12_1093 crossref_primary_10_7759_cureus_35771 crossref_primary_10_1016_j_jtcme_2023_08_005 crossref_primary_10_3390_metabo13020307 crossref_primary_10_1016_j_jep_2024_117829 crossref_primary_10_1371_journal_pone_0300965 crossref_primary_10_1016_j_prmcm_2023_100273 crossref_primary_10_2196_66831 crossref_primary_10_3390_biomedicines13040886 crossref_primary_10_1016_j_eprac_2022_08_002 crossref_primary_10_1002_jcph_2218 crossref_primary_10_3390_genes14040924 crossref_primary_10_3390_ijms24098022 crossref_primary_10_1080_00207454_2023_2292956 crossref_primary_10_20473_cimrj_v6i1_52126 crossref_primary_10_1017_S0029665122001914 crossref_primary_10_1155_2022_1445604 crossref_primary_10_3390_nu15183950 crossref_primary_10_3390_md20050338 crossref_primary_10_1038_s42003_024_06388_y crossref_primary_10_1016_j_phymed_2025_157025 crossref_primary_10_5937_mckg57_45286 crossref_primary_10_1007_s00592_025_02481_8 crossref_primary_10_2147_DMSO_S445314 crossref_primary_10_7759_cureus_49515 crossref_primary_10_3390_diseases11040184 crossref_primary_10_1016_j_brainres_2023_148611 crossref_primary_10_1093_nutrit_nuae172 crossref_primary_10_1016_j_ajg_2023_01_008 crossref_primary_10_1016_j_micpath_2025_107748 crossref_primary_10_1007_s11030_025_11149_y crossref_primary_10_3389_fendo_2024_1295967 crossref_primary_10_1016_j_carres_2024_109301 crossref_primary_10_1142_S0192415X25500703 crossref_primary_10_3390_ph18050682 crossref_primary_10_1080_08820538_2023_2205929 crossref_primary_10_1016_j_neuropharm_2023_109478 crossref_primary_10_1097_MD_0000000000039895 crossref_primary_10_7759_cureus_68686 crossref_primary_10_1016_j_jnutbio_2024_109775 crossref_primary_10_3390_biomedicines10071736 crossref_primary_10_1016_j_humgen_2023_201207 crossref_primary_10_1093_brain_awad366 crossref_primary_10_1080_09291016_2025_2480148 crossref_primary_10_3390_foods13244107 crossref_primary_10_1208_s12249_024_02828_4 crossref_primary_10_3389_fnut_2022_1039753 crossref_primary_10_1371_journal_pone_0321022 crossref_primary_10_1016_j_bbagen_2022_130188 crossref_primary_10_1016_j_mito_2024_101850 crossref_primary_10_1016_j_tice_2025_102879 crossref_primary_10_1093_nutrit_nuae157 crossref_primary_10_12998_wjcc_v11_i26_6031 crossref_primary_10_1093_abm_kaae062 crossref_primary_10_3390_ijms23020836 crossref_primary_10_1007_s40203_025_00385_7 crossref_primary_10_3389_fendo_2024_1429662 crossref_primary_10_1080_07391102_2023_2291174 crossref_primary_10_1007_s00592_024_02368_0 crossref_primary_10_1016_j_jep_2021_114762 crossref_primary_10_3390_molecules26175167 crossref_primary_10_3389_fendo_2025_1536655 crossref_primary_10_1002_ehf2_14877 crossref_primary_10_1016_j_numecd_2023_08_003 crossref_primary_10_3390_jcm14186511 crossref_primary_10_1155_2024_9960656 crossref_primary_10_1210_endocr_bqaf067 crossref_primary_10_1093_nutrit_nuae121 crossref_primary_10_1016_j_jcyt_2023_12_006 crossref_primary_10_1016_j_diabet_2022_101414 crossref_primary_10_3389_fendo_2025_1521168 crossref_primary_10_4093_dmj_2022_0244 crossref_primary_10_47419_bjbabs_v4i01_178 crossref_primary_10_1016_j_eujim_2022_102132 crossref_primary_10_1111_nhs_12922 crossref_primary_10_7759_cureus_55391 crossref_primary_10_7759_cureus_79348 crossref_primary_10_1186_s12933_023_01900_w crossref_primary_10_1080_10408398_2023_2292790 crossref_primary_10_1007_s12020_023_03329_3 crossref_primary_10_3389_fendo_2022_805837 crossref_primary_10_2478_afpuc_2025_0006 crossref_primary_10_3389_fphar_2024_1448308 crossref_primary_10_1371_journal_pone_0302777 crossref_primary_10_1016_j_nexres_2024_100108 crossref_primary_10_3389_fendo_2024_1420499 crossref_primary_10_1177_09760016251317265 crossref_primary_10_3390_genes15070942 crossref_primary_10_1016_j_obmed_2021_100329 crossref_primary_10_2147_DMSO_S409291 crossref_primary_10_1007_s43188_022_00155_z crossref_primary_10_3390_life13091831 crossref_primary_10_1093_gerona_glaf085 crossref_primary_10_1186_s13098_025_01670_3 crossref_primary_10_3390_biomedicines10082026 crossref_primary_10_1080_17446651_2025_2462100 crossref_primary_10_3390_app132011224 crossref_primary_10_4108_eetpht_9_3932 crossref_primary_10_1016_j_diabres_2023_110993 crossref_primary_10_3390_diagnostics14141507 crossref_primary_10_12677_acrem_2025_133041 crossref_primary_10_1016_j_sajb_2023_08_045 crossref_primary_10_3390_antiox14020172 crossref_primary_10_1007_s00210_024_03362_7 crossref_primary_10_1016_j_ijbiomac_2023_128565 crossref_primary_10_1186_s43162_025_00453_6 crossref_primary_10_1136_bmjopen_2022_068765 crossref_primary_10_3390_scipharm90030055 crossref_primary_10_3389_fendo_2025_1454793 crossref_primary_10_1007_s11033_022_08081_x crossref_primary_10_1016_j_jconrel_2022_10_039 crossref_primary_10_3390_ijms23042200 crossref_primary_10_3889_oamjms_2022_9507 crossref_primary_10_1007_s00210_025_04467_3 crossref_primary_10_3390_cells13080685 crossref_primary_10_1016_j_ijbiomac_2024_131644 crossref_primary_10_1016_j_jtcme_2024_05_007 crossref_primary_10_3390_diseases12120310 crossref_primary_10_1177_11795514221074679 crossref_primary_10_1186_s12890_023_02486_5 crossref_primary_10_3897_pharmacia_72_e149156 crossref_primary_10_2174_0118742106346940241212104004 crossref_primary_10_1002_elan_202100273 crossref_primary_10_1155_2021_5100531 crossref_primary_10_1371_journal_pone_0309365 crossref_primary_10_2147_DMSO_S352798 crossref_primary_10_1177_20420188241232280 crossref_primary_10_3390_jpm12040639 crossref_primary_10_1016_j_gande_2025_07_001 crossref_primary_10_1016_j_yfrne_2021_100972 crossref_primary_10_1186_s13643_024_02488_2 crossref_primary_10_1159_000528656 crossref_primary_10_3390_nu14020267 crossref_primary_10_1038_s41598_024_78287_5 crossref_primary_10_3389_fcell_2024_1473616 crossref_primary_10_3390_biomimetics10010049 crossref_primary_10_1007_s13340_024_00783_w crossref_primary_10_3390_biom13091424 crossref_primary_10_3389_fendo_2025_1479662 crossref_primary_10_3389_fendo_2024_1474232 crossref_primary_10_1080_14756366_2025_2492706 crossref_primary_10_3390_molecules30112394 crossref_primary_10_4103_PMRR_PMRR_12_24 crossref_primary_10_3390_ijerph20021520 crossref_primary_10_1016_j_lfs_2022_121015 crossref_primary_10_1016_j_lfs_2023_121770 crossref_primary_10_2196_72238 crossref_primary_10_1016_j_numecd_2024_03_014 crossref_primary_10_2174_0109298673341375241009105556 crossref_primary_10_3390_ijms242417609 crossref_primary_10_2196_60246 crossref_primary_10_3390_plants13071021 crossref_primary_10_1159_000538416 crossref_primary_10_3390_molecules27238129 crossref_primary_10_7759_cureus_89534 crossref_primary_10_1007_s00592_024_02440_9 crossref_primary_10_3389_fmed_2025_1566384 crossref_primary_10_1016_j_csm_2023_02_007 crossref_primary_10_1007_s12649_025_03266_4 crossref_primary_10_1016_j_talanta_2023_125498 crossref_primary_10_1016_j_smhs_2023_12_007 crossref_primary_10_1016_j_exer_2024_109885 crossref_primary_10_1128_iai_00509_23 crossref_primary_10_1007_s10827_022_00833_9 crossref_primary_10_1007_s44371_025_00281_1 crossref_primary_10_1186_s12944_022_01691_1 crossref_primary_10_1249_MSS_0000000000003639 crossref_primary_10_1016_j_molmet_2025_102180 crossref_primary_10_1016_j_imlet_2023_01_006 crossref_primary_10_1007_s13410_025_01449_2 crossref_primary_10_54061_jphn_1626389 crossref_primary_10_3390_ijms26031094 crossref_primary_10_1186_s12967_023_04088_5 crossref_primary_10_3390_diagnostics14192132 crossref_primary_10_3389_fendo_2022_973655 crossref_primary_10_25259_JKSUS_422_2025 crossref_primary_10_3390_ijms24086978 crossref_primary_10_1080_17518253_2023_2275666 crossref_primary_10_1007_s40200_023_01341_y crossref_primary_10_3389_fphar_2020_585876 crossref_primary_10_1017_S0007114521004001 crossref_primary_10_1093_brain_awaf057 crossref_primary_10_1080_1062936X_2022_2120068 crossref_primary_10_1007_s12013_024_01632_y crossref_primary_10_1038_s41598_025_05422_1 crossref_primary_10_1016_j_biopha_2024_116265 crossref_primary_10_1016_j_fbio_2022_102180 crossref_primary_10_3390_ijms252212115 crossref_primary_10_1002_brb3_3118 crossref_primary_10_1007_s10787_024_01556_2 crossref_primary_10_1016_j_biopha_2024_117117 crossref_primary_10_1016_j_jhazmat_2024_135096 crossref_primary_10_1007_s40200_025_01695_5 crossref_primary_10_1002_j_2040_4603_2023_tb00278_x crossref_primary_10_3390_microorganisms12061070 crossref_primary_10_1016_j_jemermed_2023_04_018 crossref_primary_10_1097_JOM_0000000000003449 crossref_primary_10_1016_j_jff_2025_106762 crossref_primary_10_4239_wjd_v15_i7_1603 crossref_primary_10_1155_jdr_5531934 crossref_primary_10_1007_s12012_024_09913_x crossref_primary_10_1186_s12944_023_01873_5 crossref_primary_10_1002_jsfa_70031 crossref_primary_10_1016_j_afres_2025_100710 crossref_primary_10_3390_ph18081101 crossref_primary_10_1016_j_nexres_2025_100463 crossref_primary_10_7759_cureus_87431 crossref_primary_10_1186_s12982_025_00509_6 crossref_primary_10_1016_j_gene_2024_148816 crossref_primary_10_1155_2022_7334080 crossref_primary_10_3389_fendo_2023_1282584 crossref_primary_10_3390_biomedicines12061275 crossref_primary_10_1002_cbdv_202401626 crossref_primary_10_1016_j_expneurol_2022_114212 crossref_primary_10_1016_j_compbiolchem_2025_108533 crossref_primary_10_3390_diagnostics14151636 crossref_primary_10_1186_s40842_023_00161_6 crossref_primary_10_7759_cureus_49120 crossref_primary_10_3390_cells12050796 crossref_primary_10_3390_ijms23136877 crossref_primary_10_1007_s40200_023_01376_1 crossref_primary_10_3390_ijms26094209 crossref_primary_10_3390_jpm14070743 crossref_primary_10_1016_j_heliyon_2024_e26962 crossref_primary_10_1007_s12668_023_01234_7 crossref_primary_10_3390_biom14040395 crossref_primary_10_1186_s12889_024_19248_5 crossref_primary_10_3390_diagnostics14151623 crossref_primary_10_1155_2022_4460041 crossref_primary_10_1002_mnfr_202400062 crossref_primary_10_1016_j_genrep_2023_101844 crossref_primary_10_1097_MD_0000000000031467 crossref_primary_10_3390_antiox10071080 crossref_primary_10_1002_ptr_8281 crossref_primary_10_1007_s44187_024_00229_x crossref_primary_10_1016_j_hsr_2023_100137 crossref_primary_10_3390_ijms21186644 crossref_primary_10_1080_14656566_2023_2181074 crossref_primary_10_1186_s12933_022_01705_3 crossref_primary_10_1007_s12020_025_04325_5 crossref_primary_10_1007_s40200_022_01070_8 crossref_primary_10_1177_20503121241261840 crossref_primary_10_3389_fphar_2022_918681 crossref_primary_10_1007_s40203_025_00337_1 crossref_primary_10_1016_j_jff_2025_106799 crossref_primary_10_1111_bcpt_13621 crossref_primary_10_2147_DDDT_S468147 crossref_primary_10_1016_j_tjnut_2024_10_036 crossref_primary_10_1159_000533481 crossref_primary_10_3390_molecules28031258 crossref_primary_10_1007_s00592_024_02309_x crossref_primary_10_7759_cureus_50138 crossref_primary_10_1007_s40135_025_00331_y crossref_primary_10_1038_s41598_023_35908_9 crossref_primary_10_1186_s12906_023_04248_6 crossref_primary_10_1038_s41366_024_01604_5 crossref_primary_10_32628_IJSRST24114141 crossref_primary_10_3390_biomedicines13010132 crossref_primary_10_1007_s11030_023_10728_1 crossref_primary_10_1007_s12020_025_04387_5 crossref_primary_10_1016_j_jad_2022_06_084 crossref_primary_10_3390_ph16040532 crossref_primary_10_3390_ijms24065195 crossref_primary_10_3390_nu15092217 crossref_primary_10_1002_slct_202500488 crossref_primary_10_3390_life13020515 crossref_primary_10_2147_DMSO_S376178 crossref_primary_10_13005_bpj_2966 crossref_primary_10_7759_cureus_18827 crossref_primary_10_3390_diabetology6080083 crossref_primary_10_1111_jdv_20694 crossref_primary_10_3390_biomedicines12091958 crossref_primary_10_1080_00325481_2023_2224036 crossref_primary_10_3389_fendo_2022_961802 crossref_primary_10_26599_FSHW_2024_9250307 crossref_primary_10_1016_j_glmedi_2025_100178 crossref_primary_10_3389_fmed_2023_1206071 crossref_primary_10_3390_ijms25168966 crossref_primary_10_1002_edm2_371 crossref_primary_10_1016_j_nfs_2024_100210 crossref_primary_10_1002_cmdc_202500350 crossref_primary_10_1016_j_molimm_2024_03_009 crossref_primary_10_3390_diagnostics13233500 crossref_primary_10_12873_433arteaga crossref_primary_10_1208_s12249_025_03195_4 crossref_primary_10_1186_s10020_024_00991_9 crossref_primary_10_3390_ijms25168933 crossref_primary_10_1007_s12020_024_03944_8 crossref_primary_10_15388_Amed_2025_32_2_3 crossref_primary_10_3390_diagnostics13101790 crossref_primary_10_1080_19476337_2023_2258209 crossref_primary_10_1186_s12889_024_20749_6 crossref_primary_10_3390_biomedicines11041126 crossref_primary_10_1080_00015385_2024_2413737 crossref_primary_10_31435_ijitss_3_47__2025_3801 crossref_primary_10_21856_j_PEP_2025_1_04 crossref_primary_10_1155_2022_9537741 crossref_primary_10_3390_nu14122549 crossref_primary_10_1016_j_fbio_2025_107455 crossref_primary_10_3390_metabo14030168 crossref_primary_10_3389_fcell_2021_701788 crossref_primary_10_1371_journal_pone_0303267 crossref_primary_10_3390_nu14153244 crossref_primary_10_1016_j_mayocp_2024_10_020 crossref_primary_10_1007_s00592_023_02030_1 crossref_primary_10_3390_nu17050754 crossref_primary_10_1002_ptr_8229 crossref_primary_10_3390_healthcare12030352 crossref_primary_10_3390_nu14132777 crossref_primary_10_3389_fendo_2022_1011187 crossref_primary_10_1080_87559129_2021_2023819 crossref_primary_10_3923_asb_2025_205_223 crossref_primary_10_1371_journal_pone_0326315 crossref_primary_10_1016_j_fbio_2025_107473 crossref_primary_10_1210_jendso_bvaf022 crossref_primary_10_7769_gesec_v15i11_4493 crossref_primary_10_1080_13813455_2023_2273221 crossref_primary_10_3390_nano14100840 crossref_primary_10_1016_j_mgene_2021_100997 crossref_primary_10_1016_j_biopha_2024_116220 crossref_primary_10_1038_s41598_023_43438_7 crossref_primary_10_1016_j_envint_2023_107741 crossref_primary_10_3390_biomedicines11020256 crossref_primary_10_3390_nu14214538 crossref_primary_10_1039_D5NR02381E crossref_primary_10_1016_j_jep_2024_119129 crossref_primary_10_1007_s42250_023_00604_8 crossref_primary_10_1016_j_lfs_2025_123408 crossref_primary_10_3390_molecules27154980 crossref_primary_10_1007_s11033_024_09793_y crossref_primary_10_3390_nu15061539 crossref_primary_10_1016_j_sciaf_2025_e02667 crossref_primary_10_2174_0118764029286890240314060427 crossref_primary_10_1007_s00044_024_03187_2 crossref_primary_10_1002_dmrr_3589 crossref_primary_10_1007_s40200_021_00839_7 crossref_primary_10_1016_j_chmed_2023_03_007 crossref_primary_10_1177_00220345231181539 crossref_primary_10_1002_ptr_8304 crossref_primary_10_1016_j_microc_2024_112565 crossref_primary_10_3389_fendo_2025_1615380 crossref_primary_10_3390_ijms24021646 crossref_primary_10_1186_s43094_024_00604_6 crossref_primary_10_1111_jdi_70024 crossref_primary_10_3390_nu15214569 crossref_primary_10_3390_genes14081572 crossref_primary_10_3390_app11209417 crossref_primary_10_3390_ijms26020753 crossref_primary_10_1128_msystems_00532_24 crossref_primary_10_1002_edm2_409 crossref_primary_10_3390_biomedicines12081630 crossref_primary_10_4093_dmj_2025_0508 crossref_primary_10_1097_CM9_0000000000003215 crossref_primary_10_1016_j_tice_2022_101764 crossref_primary_10_3389_fendo_2024_1477419 crossref_primary_10_1038_s41419_025_07525_z crossref_primary_10_1186_s12967_023_04356_4 crossref_primary_10_1515_znc_2024_0182 crossref_primary_10_1007_s40200_022_00989_2 crossref_primary_10_1111_wvn_12615 crossref_primary_10_1016_j_prenap_2025_100224 crossref_primary_10_1038_s41598_024_83917_z crossref_primary_10_1002_hpja_70020 crossref_primary_10_1016_j_ecoenv_2024_117589 crossref_primary_10_1080_10408398_2023_2278169 crossref_primary_10_29392_001c_84191 crossref_primary_10_3389_fphar_2022_924478 crossref_primary_10_1016_j_humgen_2022_201064 crossref_primary_10_1016_j_molstruc_2025_142083 crossref_primary_10_3390_nu15081971 crossref_primary_10_1111_1753_0407_70002 crossref_primary_10_1113_JP287750 crossref_primary_10_3389_fendo_2023_1109800 crossref_primary_10_1111_ijfs_16823 crossref_primary_10_1007_s40200_024_01509_0 crossref_primary_10_1038_s41598_024_61011_8 crossref_primary_10_3389_fphar_2023_1091718 crossref_primary_10_1177_1934578X251323393 crossref_primary_10_1186_s13020_023_00854_1 crossref_primary_10_1007_s10522_023_10050_1 crossref_primary_10_2174_0115734072326477240816115418 crossref_primary_10_3390_nu16223951 crossref_primary_10_1111_1753_0407_70014 crossref_primary_10_1590_0001_3765202520240800 crossref_primary_10_1016_j_bbrc_2025_151731 crossref_primary_10_1007_s13410_025_01453_6 crossref_primary_10_1016_j_jdiacomp_2025_108954 crossref_primary_10_1186_s13098_025_01891_6 crossref_primary_10_1016_j_compbiomed_2025_110542 crossref_primary_10_1111_jnc_70196 crossref_primary_10_7759_cureus_57667 crossref_primary_10_3390_biomedicines12081687 crossref_primary_10_3390_biology12060871 crossref_primary_10_13005_bpj_2520 crossref_primary_10_13005_bpj_2528 crossref_primary_10_3389_fphar_2023_1214658 crossref_primary_10_1007_s10865_024_00536_9 crossref_primary_10_1007_s12020_024_03828_x crossref_primary_10_1016_j_sajb_2024_09_027 crossref_primary_10_1016_j_envpol_2024_125031 crossref_primary_10_3389_fphys_2021_728407 crossref_primary_10_1007_s11845_023_03441_3 crossref_primary_10_4239_wjd_v14_i5_481 crossref_primary_10_1016_j_arabjc_2023_104881 crossref_primary_10_1016_j_jaim_2024_101021 crossref_primary_10_1007_s40200_024_01518_z crossref_primary_10_2337_dc22_0605 crossref_primary_10_2147_DMSO_S504882 crossref_primary_10_1016_j_jaim_2024_101025 crossref_primary_10_1016_j_atherosclerosis_2024_117545 crossref_primary_10_7759_cureus_66139 crossref_primary_10_2196_44996 crossref_primary_10_1111_dom_15693 crossref_primary_10_1097_IMNA_D_22_00026 crossref_primary_10_1111_dme_15133 crossref_primary_10_1007_s11255_025_04556_5 crossref_primary_10_7759_cureus_38961 crossref_primary_10_1111_dom_70006 crossref_primary_10_26538_tjnpr_v9i7_7 crossref_primary_10_1016_j_npep_2024_102461 crossref_primary_10_3389_fnut_2025_1619618 crossref_primary_10_5472_marumj_1480086 crossref_primary_10_1016_j_jaim_2024_101039 crossref_primary_10_3390_ph17081046 crossref_primary_10_1002_cbf_3732 crossref_primary_10_4103_aihb_aihb_61_25 crossref_primary_10_3390_ph16040541 crossref_primary_10_7717_peerj_19046 crossref_primary_10_1016_j_biopha_2024_116631 crossref_primary_10_1097_MD_0000000000039759 crossref_primary_10_3390_s23198043 crossref_primary_10_3390_life13041012 crossref_primary_10_1016_j_dsx_2024_103159 crossref_primary_10_1111_jdi_14405 crossref_primary_10_1016_j_bcp_2023_115889 crossref_primary_10_1139_apnm_2025_0017 crossref_primary_10_3390_ijerph21111537 crossref_primary_10_3390_plants11050658 crossref_primary_10_1080_17446651_2023_2279533 crossref_primary_10_3390_nu16193243 crossref_primary_10_20307_nps_2023_29_4_206 crossref_primary_10_29254_2077_4214_2025_2_177_465_474 crossref_primary_10_3390_foods11030336 crossref_primary_10_3390_nu14183815 crossref_primary_10_3892_br_2022_1537 crossref_primary_10_1016_j_jep_2023_116162 crossref_primary_10_3390_nu16203496 crossref_primary_10_3390_biomedicines11061667 crossref_primary_10_3390_nu15194119 crossref_primary_10_1038_s41598_024_58703_6 crossref_primary_10_1016_j_jff_2023_105601 crossref_primary_10_2478_enr_2022_0031 crossref_primary_10_1016_j_freeradbiomed_2024_02_020 crossref_primary_10_3389_fphar_2025_1436972 crossref_primary_10_3390_nu15204362 crossref_primary_10_7759_cureus_53279 crossref_primary_10_1093_ofid_ofae596 crossref_primary_10_1016_j_cyto_2024_156692 crossref_primary_10_2147_DMSO_S400350 crossref_primary_10_4239_wjd_v14_i6_632 crossref_primary_10_1111_ger_12777 crossref_primary_10_7759_cureus_87054 crossref_primary_10_1016_j_tig_2022_08_005 crossref_primary_10_3390_ijms23158272 crossref_primary_10_3390_biomedicines12010068 crossref_primary_10_1007_s11101_025_10132_7 crossref_primary_10_3389_fcell_2022_995732 crossref_primary_10_3390_ijms242216514 crossref_primary_10_1016_j_amjms_2024_03_023 crossref_primary_10_1007_s40200_021_00835_x crossref_primary_10_3390_ijms26168033 crossref_primary_10_1007_s11130_023_01118_x crossref_primary_10_1111_micc_12877 crossref_primary_10_7759_cureus_70611 crossref_primary_10_1038_s41467_024_51352_3 crossref_primary_10_7759_cureus_88359 crossref_primary_10_22201_ceiich_24485691e_2024_33_69817 crossref_primary_10_30649_sbj_v3i3_83 crossref_primary_10_1016_j_cellsig_2021_110219 crossref_primary_10_1089_scd_2023_0262 crossref_primary_10_3390_nu15204383 crossref_primary_10_1016_j_compbiolchem_2024_108281 crossref_primary_10_1016_j_dsx_2024_103111 crossref_primary_10_1186_s12889_024_21266_2 crossref_primary_10_1186_s12967_023_03959_1 crossref_primary_10_3390_app12031025 crossref_primary_10_3390_jcm14134588 crossref_primary_10_3389_fphar_2021_807413 crossref_primary_10_1016_j_jlr_2023_100337 crossref_primary_10_3390_biomedicines12040706 crossref_primary_10_3390_biophysica5030037 crossref_primary_10_1016_j_phymed_2023_154768 crossref_primary_10_1016_j_peptides_2022_170902 crossref_primary_10_1016_j_bbrc_2025_152174 crossref_primary_10_3389_fendo_2025_1499565 crossref_primary_10_1007_s10103_025_04571_z crossref_primary_10_1007_s11910_025_01425_7 crossref_primary_10_20307_nps_2023_29_4_242 crossref_primary_10_1016_j_mito_2025_102039 crossref_primary_10_1515_med_2024_1091 crossref_primary_10_2196_50340 crossref_primary_10_3390_biomedicines8120592 crossref_primary_10_1002_eji_70026 crossref_primary_10_1016_j_foodchem_2022_134336 crossref_primary_10_1186_s40001_025_02750_w crossref_primary_10_1016_j_bcp_2025_116908 crossref_primary_10_1016_j_jare_2025_04_020 crossref_primary_10_1371_journal_pone_0310406 crossref_primary_10_3390_metabo12100995 crossref_primary_10_1016_j_intimp_2025_115281 crossref_primary_10_1007_s42485_024_00157_5 crossref_primary_10_1186_s10020_023_00716_4 crossref_primary_10_7759_cureus_56737 crossref_primary_10_1111_dom_15294 crossref_primary_10_1016_j_compbiolchem_2023_107938 crossref_primary_10_1016_j_gene_2023_147701 crossref_primary_10_1016_j_ijbiomac_2025_147363 crossref_primary_10_33393_dti_2025_3495 crossref_primary_10_7759_cureus_89639 crossref_primary_10_1080_17568919_2024_2389767 crossref_primary_10_55735_8krphh24 crossref_primary_10_1016_j_jtemb_2022_127027 crossref_primary_10_1016_j_phymed_2022_154022 crossref_primary_10_3390_M1617 crossref_primary_10_1093_labmed_lmae052 crossref_primary_10_3390_ijms26146693 crossref_primary_10_1042_BSR20230501 crossref_primary_10_1186_s43556_023_00142_2 crossref_primary_10_2147_IJN_S522526 crossref_primary_10_1016_j_phymed_2025_157189 crossref_primary_10_3389_fphar_2025_1562116 crossref_primary_10_1016_j_heliyon_2024_e26469 crossref_primary_10_3390_medicines12030016 crossref_primary_10_1038_s41378_024_00663_y crossref_primary_10_1002_mco2_516 crossref_primary_10_1016_j_jddst_2024_105718 crossref_primary_10_1007_s44371_025_00175_2
Cites_doi	10.1038/s41586-019-1797-8 10.1001/jama.287.19.2570 10.1161/ATVBAHA.114.303284 10.1530/EC-14-0092 10.1038/emboj.2012.70 10.1210/me.2012-1004 10.1172/JCI86610 10.1515/hsz-2012-0119 10.1373/clinchem.2017.279463 10.1038/nrendo.2017.151 10.1016/j.jacc.2013.07.023 10.1155/2015/823481 10.1089/dia.2010.0240 10.1371/journal.pone.0052036 10.1586/erc.11.182 10.1074/jbc.M311786200 10.1371/journal.pone.0194127 10.1016/j.bbaexp.2005.11.005 10.1161/01.HYP.0000129281.03801.4b 10.1016/j.diabres.2014.04.006 10.2337/dc15-1585 10.2337/db11-0588 10.1016/j.cca.2014.01.015 10.1016/S0140-6736(05)66378-7 10.1074/jbc.M110.204644 10.2337/dc14-0396 10.1016/j.molcel.2015.09.025 10.1007/s00125-006-0475-1 10.1042/CS20120673 10.5114/aoms.2013.33181 10.1007/s11886-016-0745-6 10.1161/01.CIR.0000127960.28627.75 10.1152/advan.00052.2006 10.1038/nature05483 10.1111/j.1365-2265.2011.04095.x 10.1016/0140-6736(91)91164-P 10.2337/diabetes.51.4.1022 10.1089/ars.2020.8058 10.1007/s00441-008-0685-6 10.1038/s41556-018-0124-1 10.2174/1874192401105010024 10.1007/s11892-018-1057-6 10.1172/JCI27073 10.1002/oby.21832 10.1126/science.1082889 10.1210/jc.2005-0167 10.1016/0922-4106(95)90068-3 10.1152/ajpendo.2000.279.5.E1039 10.1007/s00412-009-0221-9 10.1016/j.tcm.2015.05.005 10.1016/j.molmet.2017.06.020 10.1161/CIRCRESAHA.110.225698 10.1007/s00109-015-1296-9 10.1016/j.clinbiochem.2009.05.018 10.4161/oxim.3.2.11148 10.1016/j.bbadis.2013.08.006 10.2337/dc09-S333 10.2337/diabetes.53.3.513 10.1016/S0021-9258(19)67816-6 10.7326/0003-4819-159-8-201310150-00007 10.1016/j.abb.2019.108187 10.1089/ars.2011.4407 10.2337/diacare.26.11.2999 10.1038/ng1180 10.1007/s12035-013-8551-2 10.3390/nu7042930 10.1161/ATVBAHA.111.241885 10.1039/b700706j 10.1186/1471-2350-12-60 10.1016/S0022-2275(20)39865-5 10.1074/jbc.RA118.005683 10.3945/ajcn.117.157107 10.1007/s00125-018-4777-x 10.1001/jama.281.21.2005 10.1016/S0140-6736(08)60104-X 10.1161/CIRCULATIONAHA.111.025445 10.1111/j.1749-6632.2012.06785.x 10.1016/j.atherosclerosis.2010.03.024 10.2174/157339913804143225 10.1038/nature05485 10.2337/diabetes.54.9.2685 10.1016/j.biocel.2009.09.016 10.1177/2048872612441582 10.3109/07853890.2012.705015 10.1016/j.physbeh.2017.03.040 10.1172/JCI88880 10.1073/pnas.1332551100 10.1248/bpb.34.307 10.2337/db06-1491 10.1210/jc.2008-1824 10.1056/NEJMoa021778 10.1038/nm.3779 10.2337/diacare.26.3.944 10.1093/eurheartj/eht149 10.1161/01.RES.0000170946.56981.5c 10.1016/j.tem.2011.04.007 10.1007/s11892-019-1196-4 10.1007/s00125-015-3525-8 10.1371/journal.pone.0060563 10.1159/000336664 10.1016/j.diabres.2010.01.013 10.2337/db12-0420 10.1016/S0140-6736(17)30058-2 10.1161/01.ATV.0000172689.53992.25 10.1038/nm.2279 10.1016/S0140-6736(05)61032-X 10.1161/ATVBAHA.111.241463 10.2337/dc09-S205 10.1172/JCI73066 10.3389/fphys.2019.00532 10.1016/j.molmet.2019.12.014 10.4161/isl.3.5.15935 10.1016/j.diabres.2005.12.001 10.1172/JCI5286 10.1038/s41556-018-0139-7 10.1056/NEJMoa010492 10.1016/j.febslet.2013.05.053 10.1161/CIRCRESAHA.110.223545 10.1093/cvr/cvr024 10.1093/oxfordjournals.aje.a009158 10.1177/1358836X9800300207 10.1177/1479164109344934 10.1161/circ.106.25.3143 10.1016/j.febslet.2014.09.024 10.1371/journal.pone.0023366 10.1056/NEJMoa1001689 10.1001/jama.286.3.327 10.4093/dmj.2014.38.2.143 10.1093/eurheartj/ehr112 10.1172/JCI127308 10.1016/j.tem.2013.04.001 10.1016/j.bbamcr.2010.06.013 10.1016/S0140-6736(10)60484-9 10.1038/nrm3013 10.1128/MCB.05603-11 10.1136/pgmj.69.809.204 10.1038/35008121 10.1172/JCI31021 10.1007/s00125-014-3270-4 10.1161/CIRCULATIONAHA.106.618918 10.1016/j.lfs.2016.03.059 10.2337/dc09-S206 10.1016/S0021-9258(17)39420-6 10.1007/s00125-003-1111-y 10.2337/diab.38.10.1203 10.1001/archinte.1996.00440110073010 10.1093/hmg/11.13.1581 10.2337/dc06-1813 10.1056/NEJMra1600266 10.1155/2007/21976 10.1016/S0140-6736(14)61177-6 10.1016/S0022-2275(20)37557-X 10.1007/s00018-010-0505-5 10.1093/eurheartj/ehx144 10.1038/nature07206 10.1038/nrmicro.2017.26 10.1056/NEJMoa0806470 10.2337/db18-0537 10.1016/j.molmet.2017.04.010 10.1161/ATVBAHA.116.308834 10.1016/j.atherosclerosis.2010.01.028 10.1016/j.jacl.2013.08.001 10.2337/db13-0949 10.1172/JCI0215593 10.1161/01.CIR.103.8.1057 10.1038/nature01705 10.1152/ajpendo.00572.2004 10.1016/0167-4889(88)90182-6 10.1016/j.jhep.2007.04.002 10.1007/s00592-014-0676-x 10.1172/JCI45680 10.2337/diabetes.51.5.1299 10.3390/ijms151018677 10.1038/nrendo.2014.29 10.1096/fasebj.13.14.2051 10.1038/371516a0 10.1056/NEJM199807233390404 10.1172/JCI7231 10.1016/j.vph.2012.05.005 10.2337/db10-0266 10.1007/s11357-011-9217-5 10.1155/2018/7514383 10.1007/s40618-016-0523-8 10.2337/dc12-0722 10.2337/diacare.27.6.1496 10.1056/NEJM199404073301403 10.1111/j.1600-065X.2012.01151.x 10.2337/diab.47.2.276 10.1515/CCLM.2003.181 10.1111/dom.13378 10.1002/cphy.c170046 10.1111/dom.13382 10.1007/s00125-014-3462-y 10.1016/B978-0-12-800100-4.00003-9 10.1111/1440-1681.12368 10.1055/s-2001-17407 10.2337/diab.31.4.283 10.1016/j.jacc.2005.11.046 10.1139/y2012-053 10.1016/j.tem.2017.03.003 10.2337/diacare.19.4.390 10.2337/diacare.14.9.839 10.1161/CIRCRESAHA.107.165472 10.1016/j.cmet.2011.07.015 10.3390/nu11112664 10.2337/db08-1666 10.1016/j.cub.2014.03.034 10.1073/pnas.91.23.10771 10.1001/jama.292.10.1188 10.1016/S2213-8587(15)00326-5 10.1016/j.atherosclerosis.2008.07.046 10.1016/j.neulet.2016.04.046 10.2337/db08-0391 10.11613/BM.2012.006 10.1073/pnas.1032913100 10.1007/s11538-016-0181-1 10.1016/j.amjmed.2003.10.016 10.1172/JCI10762 10.1074/jbc.R100068200 10.1038/nrg.2016.56 10.1042/BST0351171 10.1161/CIRCULATIONAHA.111.058453 10.1201/b15306 10.1210/jc.2008-2534 10.1038/nature18642 10.1161/01.ATV.19.10.2474 10.1161/ATVBAHA.108.179705 10.1371/journal.pone.0092753 10.1080/07315724.2015.1126207 10.1038/nrcardio.2010.222 10.1016/S0140-6736(04)17018-9 10.2337/dc12-2211 10.2337/diabetes.49.7.1269 10.2337/db16-1167 10.2337/dc15-2439 10.1016/S0002-9149(02)02554-7 10.1002/dmrr.1195 10.1016/j.cmet.2012.04.002 10.1210/en.2015-1066 10.2337/db07-0990 10.1016/j.cmet.2010.04.005 10.1038/nature10777 10.1038/srep44986 10.1007/BF00400828 10.1038/nrm3997 10.1161/01.CIR.80.3.719 10.1073/pnas.0810550106 10.1016/j.jacl.2013.04.001 10.1016/j.bbamcr.2015.03.013 10.1016/0002-9343(93)90144-E 10.1056/NEJMra0906948 10.2337/db09-9028 10.1161/CIRCULATIONAHA.109.897330 10.1042/bj3620513 10.1152/physrev.00008.2017 10.1146/annurev.biochem.78.070907.103946 10.3389/fimmu.2017.01882 10.1002/hep.21995 10.1007/s00125-007-0684-2 10.3389/fendo.2013.00037 10.1038/nm.4350 10.2337/diab.37.6.667 10.1038/nm724 10.1016/j.dsx.2018.04.025 10.1016/j.jdiacomp.2004.03.002 10.1016/j.jcjd.2013.06.001 10.1210/jc.2013-2373 10.1073/pnas.1108220109 10.1097/01.hco.0000200416.65370.a0 10.2337/dc19-S003 10.1073/pnas.90.11.5113 10.5483/BMBRep.2013.46.12.248
ContentType	Journal Article
Copyright	2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 by the authors. 2020
Copyright_xml	– notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020 by the authors. 2020
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM
DOI	10.3390/ijms21176275
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Proquest Research Library Research Library (Corporate) ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Publicly Available Content Database MEDLINE CrossRef MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1422-0067
ExternalDocumentID	PMC7503727 32872570 10_3390_ijms21176275
Genre	Journal Article Review
GroupedDBID	--- 29J 2WC 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AFFHD AFKRA AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU CITATION CS3 D1I DIK DU5 DWQXO E3Z EBD EBS EJD ESX F5P FRP FYUFA GNUQQ GUQSH GX1 HH5 HMCUK HYE IAO IHR ITC KQ8 LK8 M1P M2O M48 MODMG O5R O5S OK1 OVT P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO RNS RPM TR2 TUS UKHRP ~8M 3V. ABJCF ALIPV BBNVY BHPHI CGR CUY CVF ECM EIF GROUPED_DOAJ HCIFZ KB. M7P M~E NPM PDBOC 7XB 8FK ESTFP K9. MBDVC PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c478t-5f5f0357c9075a762e489dd79f80803912bf10cb3b2394b260a9b7adc2d7ab033
IEDL.DBID	BENPR
ISICitedReferencesCount	1865
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000569977700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1422-0067 1661-6596
IngestDate	Tue Nov 04 01:51:08 EST 2025 Sat Sep 27 17:15:39 EDT 2025 Tue Oct 07 07:12:50 EDT 2025 Wed Feb 19 02:28:47 EST 2025 Sat Nov 29 07:12:51 EST 2025 Tue Nov 18 21:57:40 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	17
Keywords	cardiovascular disease liver adipocyte muscle pathophysiology type 2 diabetes mellitus β-cell insulin resistance
Language	English
License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c478t-5f5f0357c9075a762e489dd79f80803912bf10cb3b2394b260a9b7adc2d7ab033
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ORCID	0000-0002-4087-8729
OpenAccessLink	https://www.proquest.com/docview/2440180571?pq-origsite=%requestingapplication%
PMID	32872570
PQID	2440180571
PQPubID	2032341
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_7503727 proquest_miscellaneous_2439630590 proquest_journals_2440180571 pubmed_primary_32872570 crossref_citationtrail_10_3390_ijms21176275 crossref_primary_10_3390_ijms21176275
PublicationCentury	2000
PublicationDate	20200830
PublicationDateYYYYMMDD	2020-08-30
PublicationDate_xml	– month: 8 year: 2020 text: 20200830 day: 30
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland – name: Basel
PublicationTitle	International journal of molecular sciences
PublicationTitleAlternate	Int J Mol Sci
PublicationYear	2020
Publisher	MDPI AG MDPI
Publisher_xml	– name: MDPI AG – name: MDPI
References	Grarup (ref_10) 2014; 57 Wautier (ref_246) 1998; 3 Sergi (ref_119) 2019; 10 Titchenell (ref_169) 2017; 28 Thorn (ref_53) 2015; 42 ref_131 Ding (ref_138) 2012; 393 ref_251 Meshkani (ref_176) 2009; 42 Nishikawa (ref_107) 2000; 404 Satoh (ref_159) 2014; 15 McCarthy (ref_22) 2010; 363 Johnson (ref_130) 2012; 249 Carey (ref_27) 1997; 145 Tan (ref_78) 2014; 121 Association (ref_63) 2019; 42 Gastaldelli (ref_165) 2017; 66 Ibrahim (ref_70) 2018; 12 Davidson (ref_184) 2009; 32 Rosen (ref_164) 2006; 444 Zhang (ref_231) 2010; 121 Wei (ref_137) 2015; 1853 Kasper (ref_72) 2014; 588 Phielix (ref_126) 2008; 57 Petersen (ref_158) 2002; 95 Gordts (ref_212) 2016; 126 Zheng (ref_36) 2018; 14 Yang (ref_140) 2010; 11 Zhou (ref_220) 2009; 6 Fu (ref_38) 2013; 9 Ye (ref_264) 2015; 156 Blasiole (ref_205) 2007; 3 Athyros (ref_237) 2011; 5 Simoneau (ref_121) 1999; 13 Mootha (ref_123) 2003; 34 Kim (ref_261) 2007; 117 Coelho (ref_163) 2013; 9 Pan (ref_277) 2010; 88 Cherrington (ref_170) 2007; 35 Joshi (ref_257) 2013; 587 Guarner (ref_111) 2015; 40 Turner (ref_82) 1999; 281 Verges (ref_203) 2010; 211 Eckel (ref_233) 2005; 365 ref_274 Northcott (ref_258) 2012; 90 ref_276 Rosen (ref_90) 2018; 67 ref_156 Simmons (ref_89) 2008; 1 Lustig (ref_45) 1993; 90 Tawata (ref_150) 1998; 47 Ihnat (ref_85) 2007; 50 Maki (ref_168) 2011; 13 Bogdanovic (ref_100) 2009; 118 Halban (ref_39) 1994; 37 Lin (ref_144) 2018; 2018 Chait (ref_224) 1993; 94 Blomen (ref_99) 2011; 68 Lin (ref_204) 1995; 36 Reddy (ref_98) 2015; 58 Park (ref_69) 2013; 98 Petersen (ref_114) 2003; 300 Patti (ref_124) 2003; 100 Fuchsberger (ref_21) 2016; 536 Taskinen (ref_190) 2003; 46 Wang (ref_149) 2001; 109 ref_145 Choi (ref_207) 2011; 22 Leclercq (ref_175) 2007; 47 Vandanmagsar (ref_62) 2011; 17 McKeigue (ref_19) 1991; 337 Shigenaga (ref_118) 1994; 91 Schellenberg (ref_13) 2013; 159 Franks (ref_25) 2013; 36 Oh (ref_173) 2013; 46 Kearney (ref_239) 2008; 371 Sircana (ref_75) 2018; 18 Latreille (ref_95) 2014; 124 Laakso (ref_185) 2014; 10 Christensen (ref_50) 2019; 19 Iwashima (ref_269) 2004; 43 Mosammaparast (ref_101) 2010; 79 Simon (ref_46) 1995; 291 Cohn (ref_198) 1999; 19 Biagi (ref_74) 2012; 34 Boland (ref_40) 2017; 6 Karter (ref_17) 2013; 36 Varbo (ref_195) 2018; 64 Steinberg (ref_197) 1989; 80 Mecili (ref_55) 2013; 45 Ginsberg (ref_201) 1991; 14 Lewis (ref_214) 2005; 96 Cerf (ref_35) 2013; 4 Ginsberg (ref_234) 2000; 106 Ezraty (ref_128) 2017; 15 Strasser (ref_33) 2013; 1281 Nordestgaard (ref_192) 2014; 384 LaPierre (ref_92) 2017; 6 Dullaart (ref_268) 2010; 211 Fisher (ref_206) 2002; 277 Reaven (ref_182) 2012; 32 Shamsuzzaman (ref_64) 2004; 109 Wu (ref_162) 2017; 127 Lamarche (ref_217) 1999; 103 Battisti (ref_186) 2003; 41 Wong (ref_11) 2016; 39 Ouchi (ref_272) 2001; 103 Scherer (ref_167) 2019; 62 ref_116 Lynch (ref_71) 2016; 375 Hotamisligil (ref_250) 2006; 444 Ezenwaka (ref_267) 2005; 63 Hillier (ref_29) 2003; 26 Choi (ref_286) 2011; 75 Giacco (ref_58) 2010; 107 Sinha (ref_28) 2002; 51 Elsaid (ref_280) 2018; 13 Esguerra (ref_93) 2018; 20 Flannick (ref_24) 2016; 17 Edgerton (ref_171) 2006; 116 Sattar (ref_18) 2015; 3 Dabelea (ref_15) 2009; 32 Bunney (ref_37) 2017; 176 Pearson (ref_154) 2016; 78 Verweij (ref_196) 2017; 37 Kadowaki (ref_146) 1994; 330 Kim (ref_122) 2000; 279 Farbstein (ref_232) 2012; 10 Zeadin (ref_255) 2013; 37 Chatterjee (ref_4) 2017; 389 Chan (ref_14) 1993; 69 Engerman (ref_87) 1989; 38 Hoogeveen (ref_225) 2014; 34 Pradhan (ref_61) 2001; 286 Beckman (ref_179) 2002; 287 Fogelman (ref_215) 1985; 260 McGillicuddy (ref_230) 2011; 124 Caligiuri (ref_266) 2008; 47 Cani (ref_77) 2007; 56 Chung (ref_229) 2011; 124 Kelley (ref_120) 1999; 277 Bays (ref_227) 2013; 7 Esser (ref_60) 2014; 105 Weinstein (ref_30) 2004; 292 Paneni (ref_238) 2013; 34 Polak (ref_66) 2017; 40 Cuinas (ref_44) 2016; 155 Roden (ref_1) 2019; 576 Jheng (ref_143) 2012; 32 Ofori (ref_94) 2017; 7 DeFronzo (ref_160) 1988; 37 Poulton (ref_151) 2002; 11 Agra (ref_282) 2017; 25 Schwartz (ref_7) 2016; 39 Mooradian (ref_228) 2004; 53 Meng (ref_253) 2014; 49 Dimas (ref_23) 2014; 63 Laatsch (ref_211) 2009; 204 Wilcox (ref_155) 2005; 26 Yamauchi (ref_262) 2003; 423 Sebastian (ref_142) 2012; 109 Montal (ref_174) 2015; 60 Gerin (ref_172) 2002; 362 Cai (ref_279) 2009; 89 Lewis (ref_187) 1996; 19 Montgomery (ref_132) 2015; 4 Kessler (ref_241) 1998; 24 Lathief (ref_221) 2016; 26 Breving (ref_102) 2010; 42 Rorsman (ref_41) 2018; 98 Kanter (ref_209) 2019; 129 McNamara (ref_223) 1996; 37 Tang (ref_79) 2015; 21 Blachier (ref_48) 1988; 970 ref_26 Liu (ref_54) 2018; 20 Shan (ref_81) 2017; 106 Yusuf (ref_235) 2004; 364 Islam (ref_43) 2002; 51 Tan (ref_278) 2008; 57 Dimova (ref_284) 2015; 2015 Yamagishi (ref_243) 2010; 3 Haines (ref_20) 2007; 30 Krauss (ref_216) 2004; 27 Fang (ref_263) 2018; 8 Wahid (ref_91) 2010; 1803 Kroon (ref_194) 2016; 18 Adiels (ref_202) 2005; 25 Libby (ref_248) 2012; 32 Weyer (ref_3) 1999; 104 Grundy (ref_199) 2006; 21 Venkatasamy (ref_32) 2013; 7 Scarpellini (ref_73) 2012; 30 Schieber (ref_127) 2014; 24 Khera (ref_219) 2011; 364 Sarwar (ref_9) 2010; 375 Reddy (ref_105) 2011; 90 Horton (ref_208) 2002; 109 Neis (ref_80) 2015; 7 Bornfeldt (ref_183) 2011; 14 Defronzo (ref_6) 2009; 58 Sattar (ref_271) 2006; 114 Yamawaki (ref_259) 2011; 34 Olsen (ref_88) 2012; 61 Hu (ref_12) 2001; 345 Grundy (ref_200) 2006; 47 Maeda (ref_260) 2002; 8 Yamamoto (ref_52) 2019; 294 Handschin (ref_68) 2008; 454 Tawata (ref_148) 2000; 49 Kooi (ref_125) 2007; 50 Menegazzo (ref_256) 2015; 52 ref_57 Kowluru (ref_108) 2007; 2007 ref_177 Thompson (ref_110) 2013; 125 Wang (ref_281) 2020; 679 Boren (ref_193) 2014; 431 Tang (ref_152) 2006; 73 ref_181 Sena (ref_244) 2013; 1832 Margetic (ref_245) 2012; 22 Liu (ref_16) 2009; 32 Miao (ref_104) 2004; 279 Goldberg (ref_240) 2009; 94 Lynch (ref_31) 1996; 156 Sazanov (ref_115) 2015; 16 Novak (ref_136) 2012; 17 Yang (ref_273) 2006; 290 Karnib (ref_106) 2016; 625 Liang (ref_134) 2006; 30 Guyton (ref_236) 2013; 62 Quiros (ref_141) 2012; 31 Giannini (ref_242) 2011; 27 Bakker (ref_247) 2009; 335 Mirzaei (ref_283) 2016; 35 Czech (ref_153) 2017; 23 Li (ref_49) 1991; 266 Navab (ref_218) 2011; 8 Valera (ref_47) 1994; 371 Li (ref_76) 2017; 8 Stump (ref_113) 2003; 100 Brasacchio (ref_103) 2009; 58 Latreille (ref_97) 2015; 93 Toth (ref_213) 2013; 7 Hummasti (ref_56) 2010; 107 Chavez (ref_133) 2012; 15 Witztum (ref_226) 1982; 31 Ference (ref_222) 2017; 38 Mandal (ref_265) 2011; 286 Czech (ref_166) 2020; 34 Seino (ref_42) 2011; 121 Pilz (ref_270) 2005; 90 Bach (ref_135) 2005; 54 Badimon (ref_249) 2012; 1 Halban (ref_51) 2014; 37 Koenen (ref_254) 2011; 60 Esteghamati (ref_285) 2014; 38 Chapman (ref_191) 2011; 32 Stumvoll (ref_2) 2005; 365 Lee (ref_252) 2013; 62 Holman (ref_84) 2008; 359 Gaede (ref_8) 2003; 348 Ross (ref_34) 2003; 26 Spinelli (ref_117) 2018; 20 Westermann (ref_139) 2010; 11 Kim (ref_112) 2008; 102 Verges (ref_189) 2015; 58 Bostrom (ref_67) 2012; 481 Ceriello (ref_129) 2012; 57 DeFronzo (ref_161) 2010; 2010 Graciano (ref_59) 2011; 3 Leeuwenburgh (ref_65) 1994; 267 Poy (ref_96) 2009; 106 Haffner (ref_178) 1998; 339 Haas (ref_210) 2013; 24 Kowluru (ref_109) 2004; 18 Gaede (ref_83) 2003; 165 Nesto (ref_180) 2004; 116 Ceriello (ref_86) 2009; 94 Schaffler (ref_275) 2005; 1732 Petersen (ref_157) 2002; 90 ref_5 Sparks (ref_188) 2012; 32 Yang (ref_147) 2012; 26
References_xml	– volume: 576 start-page: 51 year: 2019 ident: ref_1 article-title: The integrative biology of type 2 diabetes publication-title: Nature doi: 10.1038/s41586-019-1797-8 – volume: 26 start-page: 19 year: 2005 ident: ref_155 article-title: Insulin and insulin resistance publication-title: Clin. Biochem. Rev. – volume: 287 start-page: 2570 year: 2002 ident: ref_179 article-title: Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management publication-title: JAMA doi: 10.1001/jama.287.19.2570 – volume: 34 start-page: 1069 year: 2014 ident: ref_225 article-title: Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: The Atherosclerosis Risk In Communities (ARIC) study publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.114.303284 – volume: 4 start-page: R1 year: 2015 ident: ref_132 article-title: Mitochondrial dysfunction and insulin resistance: An update publication-title: Endocr. Connect. doi: 10.1530/EC-14-0092 – volume: 31 start-page: 2117 year: 2012 ident: ref_141 article-title: Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice publication-title: EMBO J. doi: 10.1038/emboj.2012.70 – volume: 26 start-page: 1203 year: 2012 ident: ref_147 article-title: Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes publication-title: Mol. Endocrinol. doi: 10.1210/me.2012-1004 – volume: 126 start-page: 2855 year: 2016 ident: ref_212 article-title: ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors publication-title: J. Clin. Investig. doi: 10.1172/JCI86610 – volume: 393 start-page: 547 year: 2012 ident: ref_138 article-title: Mitophagy: Mechanisms, pathophysiological roles, and analysis publication-title: Biol. Chem. doi: 10.1515/hsz-2012-0119 – volume: 64 start-page: 219 year: 2018 ident: ref_195 article-title: Remnant Cholesterol and Myocardial Infarction in Normal Weight, Overweight, and Obese Individuals from the Copenhagen General Population Study publication-title: Clin. Chem. doi: 10.1373/clinchem.2017.279463 – volume: 63 start-page: 64 year: 2005 ident: ref_267 article-title: Caribbean female patients with type 2 diabetes mellitus have lower serum levels of adiponectin than nondiabetic subjects publication-title: Neth. J. Med. – volume: 14 start-page: 88 year: 2018 ident: ref_36 article-title: Global aetiology and epidemiology of type 2 diabetes mellitus and its complications publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2017.151 – volume: 62 start-page: 1580 year: 2013 ident: ref_236 article-title: Relationship of lipoproteins to cardiovascular events: The AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2013.07.023 – volume: 2015 start-page: 823481 year: 2015 ident: ref_284 article-title: The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis publication-title: Biomed. Res. Int. doi: 10.1155/2015/823481 – volume: 13 start-page: 661 year: 2011 ident: ref_168 article-title: Validation of insulin sensitivity and secretion indices derived from the liquid meal tolerance test publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2010.0240 – ident: ref_177 doi: 10.1371/journal.pone.0052036 – volume: 10 start-page: 353 year: 2012 ident: ref_232 article-title: HDL dysfunction in diabetes: Causes and possible treatments publication-title: Expert Rev. Cardiovasc. Ther. doi: 10.1586/erc.11.182 – volume: 279 start-page: 18091 year: 2004 ident: ref_104 article-title: In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions publication-title: J. Biol. Chem. doi: 10.1074/jbc.M311786200 – ident: ref_26 doi: 10.1371/journal.pone.0194127 – volume: 1732 start-page: 96 year: 2005 ident: ref_275 article-title: Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbaexp.2005.11.005 – volume: 43 start-page: 1318 year: 2004 ident: ref_269 article-title: Hypoadiponectinemia is an independent risk factor for hypertension publication-title: Hypertension doi: 10.1161/01.HYP.0000129281.03801.4b – volume: 2010 start-page: 476279 year: 2010 ident: ref_161 article-title: Pathogenesis of insulin resistance in skeletal muscle publication-title: J. Biomed. Biotechnol. – volume: 105 start-page: 141 year: 2014 ident: ref_60 article-title: Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2014.04.006 – volume: 39 start-page: 179 year: 2016 ident: ref_7 article-title: The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the beta-Cell-Centric Classification Schema publication-title: Diabetes Care doi: 10.2337/dc15-1585 – volume: 61 start-page: 485 year: 2012 ident: ref_88 article-title: Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression publication-title: Diabetes doi: 10.2337/db11-0588 – volume: 431 start-page: 131 year: 2014 ident: ref_193 article-title: Postprandial hypertriglyceridemia as a coronary risk factor publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2014.01.015 – volume: 365 start-page: 1415 year: 2005 ident: ref_233 article-title: The metabolic syndrome publication-title: Lancet doi: 10.1016/S0140-6736(05)66378-7 – volume: 286 start-page: 13460 year: 2011 ident: ref_265 article-title: Molecular mechanism for adiponectin-dependent M2 macrophage polarization: Link between the metabolic and innate immune activity of full-length adiponectin publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.204644 – volume: 37 start-page: 1751 year: 2014 ident: ref_51 article-title: beta-cell failure in type 2 diabetes: Postulated mechanisms and prospects for prevention and treatment publication-title: Diabetes Care doi: 10.2337/dc14-0396 – volume: 60 start-page: 571 year: 2015 ident: ref_174 article-title: PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth publication-title: Mol. Cell. doi: 10.1016/j.molcel.2015.09.025 – volume: 50 start-page: 113 year: 2007 ident: ref_125 article-title: Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects publication-title: Diabetologia doi: 10.1007/s00125-006-0475-1 – volume: 125 start-page: 19 year: 2013 ident: ref_110 article-title: Potential role of Toll-like receptors in programming of vascular dysfunction publication-title: Clin. Sci. (Lond.) doi: 10.1042/CS20120673 – volume: 9 start-page: 191 year: 2013 ident: ref_163 article-title: Biochemistry of adipose tissue: An endocrine organ publication-title: Arch. Med. Sci. doi: 10.5114/aoms.2013.33181 – volume: 18 start-page: 67 year: 2016 ident: ref_194 article-title: Triglyceride-Rich Lipoproteins and Remnants: Targets for Therapy? publication-title: Curr. Cardiol. Rep. doi: 10.1007/s11886-016-0745-6 – volume: 109 start-page: 2181 year: 2004 ident: ref_64 article-title: Independent association between plasma leptin and C-reactive protein in healthy humans publication-title: Circulation doi: 10.1161/01.CIR.0000127960.28627.75 – volume: 30 start-page: 145 year: 2006 ident: ref_134 article-title: PGC-1alpha: A key regulator of energy metabolism publication-title: Adv. Physiol. Educ. doi: 10.1152/advan.00052.2006 – volume: 444 start-page: 847 year: 2006 ident: ref_164 article-title: Adipocytes as regulators of energy balance and glucose homeostasis publication-title: Nature doi: 10.1038/nature05483 – volume: 75 start-page: 628 year: 2011 ident: ref_286 article-title: Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women publication-title: Clin. Endocrinol. (Oxf.) doi: 10.1111/j.1365-2265.2011.04095.x – volume: 337 start-page: 382 year: 1991 ident: ref_19 article-title: Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians publication-title: Lancet doi: 10.1016/0140-6736(91)91164-P – volume: 51 start-page: 1022 year: 2002 ident: ref_28 article-title: Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: Relationships to insulin sensitivity, total body fat, and central adiposity publication-title: Diabetes doi: 10.2337/diabetes.51.4.1022 – ident: ref_131 doi: 10.1089/ars.2020.8058 – volume: 335 start-page: 165 year: 2009 ident: ref_247 article-title: Endothelial dysfunction and diabetes: Roles of hyperglycemia, impaired insulin signaling and obesity publication-title: Cell. Tissue Res. doi: 10.1007/s00441-008-0685-6 – volume: 20 start-page: 745 year: 2018 ident: ref_117 article-title: The multifaceted contributions of mitochondria to cellular metabolism publication-title: Nat. Cell. Biol. doi: 10.1038/s41556-018-0124-1 – volume: 5 start-page: 24 year: 2011 ident: ref_237 article-title: Dyslipidaemia of obesity, metabolic syndrome and type 2 diabetes mellitus: The case for residual risk reduction after statin treatment publication-title: Open Cardiovasc. Med. J. doi: 10.2174/1874192401105010024 – volume: 18 start-page: 98 year: 2018 ident: ref_75 article-title: Altered Gut Microbiota in Type 2 Diabetes: Just a Coincidence? publication-title: Curr. Diabetes Rep. doi: 10.1007/s11892-018-1057-6 – volume: 116 start-page: 521 year: 2006 ident: ref_171 article-title: Insulin’s direct effects on the liver dominate the control of hepatic glucose production publication-title: J. Clin. Investig. doi: 10.1172/JCI27073 – volume: 25 start-page: 1042 year: 2017 ident: ref_282 article-title: Omentin treatment of epicardial fat improves its anti-inflammatory activity and paracrine benefit on smooth muscle cells publication-title: Obesity (Silver Spring) doi: 10.1002/oby.21832 – volume: 300 start-page: 1140 year: 2003 ident: ref_114 article-title: Mitochondrial dysfunction in the elderly: Possible role in insulin resistance publication-title: Science doi: 10.1126/science.1082889 – volume: 90 start-page: 4792 year: 2005 ident: ref_270 article-title: Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2005-0167 – volume: 291 start-page: 281 year: 1995 ident: ref_46 article-title: Characterisation of a recombinant P2Y purinoceptor publication-title: Eur. J. Pharmacol. doi: 10.1016/0922-4106(95)90068-3 – volume: 279 start-page: E1039 year: 2000 ident: ref_122 article-title: Lipid oxidation is reduced in obese human skeletal muscle publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.2000.279.5.E1039 – volume: 118 start-page: 549 year: 2009 ident: ref_100 article-title: DNA methylation and methyl-CpG binding proteins: Developmental requirements and function publication-title: Chromosoma doi: 10.1007/s00412-009-0221-9 – volume: 26 start-page: 165 year: 2016 ident: ref_221 article-title: Approach to diabetes management in patients with CVD publication-title: Trends Cardiovasc. Med. doi: 10.1016/j.tcm.2015.05.005 – volume: 6 start-page: 1010 year: 2017 ident: ref_92 article-title: MicroRNAs as stress regulators in pancreatic beta cells and diabetes publication-title: Mol. Metab. doi: 10.1016/j.molmet.2017.06.020 – volume: 107 start-page: 579 year: 2010 ident: ref_56 article-title: Endoplasmic reticulum stress and inflammation in obesity and diabetes publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.110.225698 – volume: 93 start-page: 1159 year: 2015 ident: ref_97 article-title: miR-375 gene dosage in pancreatic beta-cells: Implications for regulation of beta-cell mass and biomarker development publication-title: J. Mol. Med. (Berl.) doi: 10.1007/s00109-015-1296-9 – volume: 42 start-page: 1331 year: 2009 ident: ref_176 article-title: Hepatic insulin resistance, metabolic syndrome and cardiovascular disease publication-title: Clin. Biochem. doi: 10.1016/j.clinbiochem.2009.05.018 – volume: 3 start-page: 101 year: 2010 ident: ref_243 article-title: Advanced glycation end products, oxidative stress and diabetic nephropathy publication-title: Oxid. Med. Cell. Longev. doi: 10.4161/oxim.3.2.11148 – volume: 1832 start-page: 2216 year: 2013 ident: ref_244 article-title: Endothelial dysfunction—a major mediator of diabetic vascular disease publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2013.08.006 – volume: 32 start-page: S331 year: 2009 ident: ref_184 article-title: Is hyperglycemia a causal factor in cardiovascular disease? Does proving this relationship really matter? Yes publication-title: Diabetes Care doi: 10.2337/dc09-S333 – volume: 53 start-page: 513 year: 2004 ident: ref_228 article-title: Transcriptional control of apolipoprotein A-I gene expression in diabetes publication-title: Diabetes doi: 10.2337/diabetes.53.3.513 – volume: 266 start-page: 3449 year: 1991 ident: ref_49 article-title: Extracellular ATP causes Ca2(+)− dependent and -independent insulin secretion in RINm5F cells. Phospholipase C mediates Ca2+ mobilization but not Ca2+ influx and membrane depolarization publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)67816-6 – volume: 159 start-page: 543 year: 2013 ident: ref_13 article-title: Lifestyle interventions for patients with and at risk for type 2 diabetes: A systematic review and meta-analysis publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-159-8-201310150-00007 – volume: 679 start-page: 108187 year: 2020 ident: ref_281 article-title: Omentin-1 attenuates lipopolysaccharide (LPS)-induced U937 macrophages activation by inhibiting the TLR4/MyD88/NF-kappaB signaling publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2019.108187 – volume: 17 start-page: 794 year: 2012 ident: ref_136 article-title: Mitophagy: A complex mechanism of mitochondrial removal publication-title: Antioxid. Redox. Signal doi: 10.1089/ars.2011.4407 – volume: 26 start-page: 2999 year: 2003 ident: ref_29 article-title: Complications in young adults with early-onset type 2 diabetes: Losing the relative protection of youth publication-title: Diabetes Care doi: 10.2337/diacare.26.11.2999 – volume: 34 start-page: 267 year: 2003 ident: ref_123 article-title: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes publication-title: Nat. Genet. doi: 10.1038/ng1180 – volume: 49 start-page: 673 year: 2014 ident: ref_253 article-title: Nod-like receptor protein 1 inflammasome mediates neuron injury under high glucose publication-title: Mol. Neurobiol. doi: 10.1007/s12035-013-8551-2 – volume: 7 start-page: 2930 year: 2015 ident: ref_80 article-title: The role of microbial amino acid metabolism in host metabolism publication-title: Nutrients doi: 10.3390/nu7042930 – volume: 32 start-page: 1754 year: 2012 ident: ref_182 article-title: Insulin resistance and coronary heart disease in nondiabetic individuals publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.111.241885 – volume: 3 start-page: 608 year: 2007 ident: ref_205 article-title: The physiological and molecular regulation of lipoprotein assembly and secretion publication-title: Mol. Biosyst. doi: 10.1039/b700706j – ident: ref_276 doi: 10.1186/1471-2350-12-60 – volume: 36 start-page: 1073 year: 1995 ident: ref_204 article-title: Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: Insulin negatively regulates MTP gene expression publication-title: J. Lipid. Res. doi: 10.1016/S0022-2275(20)39865-5 – volume: 294 start-page: 168 year: 2019 ident: ref_52 article-title: Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic beta cell publication-title: J. Biol. Chem. doi: 10.1074/jbc.RA118.005683 – volume: 106 start-page: 888 year: 2017 ident: ref_81 article-title: Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.117.157107 – volume: 1 start-page: 6 year: 2008 ident: ref_89 article-title: Epigenetic Influences and Disease publication-title: Nat. Educ. – volume: 62 start-page: 223 year: 2019 ident: ref_167 article-title: The many secret lives of adipocytes: Implications for diabetes publication-title: Diabetologia doi: 10.1007/s00125-018-4777-x – volume: 281 start-page: 2005 year: 1999 ident: ref_82 article-title: Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group publication-title: JAMA doi: 10.1001/jama.281.21.2005 – volume: 371 start-page: 117 year: 2008 ident: ref_239 article-title: Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: A meta-analysis publication-title: Lancet doi: 10.1016/S0140-6736(08)60104-X – volume: 124 start-page: 1663 year: 2011 ident: ref_229 article-title: Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.111.025445 – volume: 1281 start-page: 141 year: 2013 ident: ref_33 article-title: Physical activity in obesity and metabolic syndrome publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2012.06785.x – volume: 211 start-page: 393 year: 2010 ident: ref_268 article-title: Carotid intima media thickness is associated with plasma adiponectin but not with the leptin:adiponectin ratio independently of metabolic syndrome publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2010.03.024 – volume: 9 start-page: 25 year: 2013 ident: ref_38 article-title: Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes publication-title: Curr. Diabetes Rev. doi: 10.2174/157339913804143225 – volume: 444 start-page: 860 year: 2006 ident: ref_250 article-title: Inflammation and metabolic disorders publication-title: Nature doi: 10.1038/nature05485 – volume: 54 start-page: 2685 year: 2005 ident: ref_135 article-title: Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: Effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6 publication-title: Diabetes doi: 10.2337/diabetes.54.9.2685 – volume: 42 start-page: 1316 year: 2010 ident: ref_102 article-title: The complexities of microRNA regulation: Mirandering around the rules publication-title: Int. J. Biochem. Cell. Biol. doi: 10.1016/j.biocel.2009.09.016 – volume: 1 start-page: 60 year: 2012 ident: ref_249 article-title: Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease publication-title: Eur. Heart J. Acute Cardiovasc. Care doi: 10.1177/2048872612441582 – volume: 45 start-page: 242 year: 2013 ident: ref_55 article-title: Metabolic inflammation: Connecting obesity and insulin resistance publication-title: Ann. Med. doi: 10.3109/07853890.2012.705015 – volume: 176 start-page: 139 year: 2017 ident: ref_37 article-title: Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet publication-title: Physiol. Behav. doi: 10.1016/j.physbeh.2017.03.040 – volume: 127 start-page: 43 year: 2017 ident: ref_162 article-title: Skeletal muscle inflammation and insulin resistance in obesity publication-title: J. Clin. Investig. doi: 10.1172/JCI88880 – volume: 100 start-page: 7996 year: 2003 ident: ref_113 article-title: Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1332551100 – volume: 34 start-page: 307 year: 2011 ident: ref_259 article-title: Vascular effects of novel adipocytokines: Focus on vascular contractility and inflammatory responses publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.34.307 – volume: 56 start-page: 1761 year: 2007 ident: ref_77 article-title: Metabolic endotoxemia initiates obesity and insulin resistance publication-title: Diabetes doi: 10.2337/db06-1491 – volume: 94 start-page: 410 year: 2009 ident: ref_86 article-title: Clinical review 2: The “metabolic memory”: Is more than just tight glucose control necessary to prevent diabetic complications? publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2008-1824 – volume: 348 start-page: 383 year: 2003 ident: ref_8 article-title: Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa021778 – volume: 21 start-page: 173 year: 2015 ident: ref_79 article-title: Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes publication-title: Nat. Med. doi: 10.1038/nm.3779 – volume: 26 start-page: 944 year: 2003 ident: ref_34 article-title: Does exercise without weight loss improve insulin sensitivity? publication-title: Diabetes Care doi: 10.2337/diacare.26.3.944 – volume: 34 start-page: 2436 year: 2013 ident: ref_238 article-title: Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part I publication-title: Eur. Heart J. doi: 10.1093/eurheartj/eht149 – volume: 96 start-page: 1221 year: 2005 ident: ref_214 article-title: New insights into the regulation of HDL metabolism and reverse cholesterol transport publication-title: Circ. Res. doi: 10.1161/01.RES.0000170946.56981.5c – volume: 22 start-page: 353 year: 2011 ident: ref_207 article-title: Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2011.04.007 – volume: 19 start-page: 81 year: 2019 ident: ref_50 article-title: The Beta Cell in Type 2 Diabetes publication-title: Curr. Diabetes Rep. doi: 10.1007/s11892-019-1196-4 – volume: 58 start-page: 886 year: 2015 ident: ref_189 article-title: Pathophysiology of diabetic dyslipidaemia: Where are we? publication-title: Diabetologia doi: 10.1007/s00125-015-3525-8 – ident: ref_57 doi: 10.1371/journal.pone.0060563 – volume: 30 start-page: 148 year: 2012 ident: ref_73 article-title: Obesity and metabolic syndrome: An inflammatory condition publication-title: Dig. Dis. doi: 10.1159/000336664 – volume: 88 start-page: 29 year: 2010 ident: ref_277 article-title: Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2010.01.013 – volume: 62 start-page: 194 year: 2013 ident: ref_252 article-title: Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes publication-title: Diabetes doi: 10.2337/db12-0420 – volume: 389 start-page: 2239 year: 2017 ident: ref_4 article-title: Type 2 diabetes publication-title: Lancet doi: 10.1016/S0140-6736(17)30058-2 – volume: 25 start-page: 1697 year: 2005 ident: ref_202 article-title: Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000172689.53992.25 – volume: 17 start-page: 179 year: 2011 ident: ref_62 article-title: The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance publication-title: Nat. Med. doi: 10.1038/nm.2279 – volume: 365 start-page: 1333 year: 2005 ident: ref_2 article-title: Type 2 diabetes: Principles of pathogenesis and therapy publication-title: Lancet doi: 10.1016/S0140-6736(05)61032-X – volume: 32 start-page: 2104 year: 2012 ident: ref_188 article-title: Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.111.241463 – volume: 32 start-page: S133 year: 2009 ident: ref_16 article-title: Type 1 and Type 2 diabetes in Asian and Pacific Islander U.S. youth: The SEARCH for Diabetes in Youth Study publication-title: Diabetes Care doi: 10.2337/dc09-S205 – volume: 124 start-page: 2722 year: 2014 ident: ref_95 article-title: MicroRNA-7a regulates pancreatic beta cell function publication-title: J. Clin. Investig. doi: 10.1172/JCI73066 – volume: 10 start-page: 532 year: 2019 ident: ref_119 article-title: Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet publication-title: Front. Physiol. doi: 10.3389/fphys.2019.00532 – volume: 34 start-page: 27 year: 2020 ident: ref_166 article-title: Mechanisms of insulin resistance related to white, beige, and brown adipocytes publication-title: Mol. Metab. doi: 10.1016/j.molmet.2019.12.014 – volume: 3 start-page: 213 year: 2011 ident: ref_59 article-title: Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets publication-title: Islets doi: 10.4161/isl.3.5.15935 – volume: 73 start-page: 77 year: 2006 ident: ref_152 article-title: Variation of mitochondrial gene and the association with type 2 diabetes mellitus in a Chinese population publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2005.12.001 – volume: 103 start-page: 1191 year: 1999 ident: ref_217 article-title: Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men publication-title: J. Clin. Investig. doi: 10.1172/JCI5286 – ident: ref_116 doi: 10.1038/s41556-018-0139-7 – volume: 345 start-page: 790 year: 2001 ident: ref_12 article-title: Diet, lifestyle, and the risk of type 2 diabetes mellitus in women publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa010492 – volume: 587 start-page: 2241 year: 2013 ident: ref_257 article-title: High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation publication-title: FEBS Lett. doi: 10.1016/j.febslet.2013.05.053 – volume: 107 start-page: 1058 year: 2010 ident: ref_58 article-title: Oxidative stress and diabetic complications publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.110.223545 – volume: 90 start-page: 421 year: 2011 ident: ref_105 article-title: Epigenetic mechanisms in diabetic vascular complications publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvr024 – volume: 145 start-page: 614 year: 1997 ident: ref_27 article-title: Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses’ Health Study publication-title: Am. J. Epidemiol. doi: 10.1093/oxfordjournals.aje.a009158 – volume: 3 start-page: 131 year: 1998 ident: ref_246 article-title: Diabetes, advanced glycation endproducts and vascular disease publication-title: Vasc. Med. doi: 10.1177/1358836X9800300207 – volume: 6 start-page: 238 year: 2009 ident: ref_220 article-title: Impaired serum capacity to induce cholesterol efflux is associated with endothelial dysfunction in type 2 diabetes mellitus publication-title: Diabetes Vasc. Dis. Res. doi: 10.1177/1479164109344934 – ident: ref_181 doi: 10.1161/circ.106.25.3143 – volume: 588 start-page: 4214 year: 2014 ident: ref_72 article-title: Gut microbiome and the risk factors in central nervous system autoimmunity publication-title: FEBS Lett. doi: 10.1016/j.febslet.2014.09.024 – ident: ref_251 doi: 10.1371/journal.pone.0023366 – volume: 364 start-page: 127 year: 2011 ident: ref_219 article-title: Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1001689 – volume: 165 start-page: 2658 year: 2003 ident: ref_83 article-title: The Steno-2 study. Intensive multifactorial intervention reduces the occurrence of cardiovascular disease in patients with type 2 diabetes publication-title: Ugeskr. Laeger. – volume: 286 start-page: 327 year: 2001 ident: ref_61 article-title: C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus publication-title: JAMA doi: 10.1001/jama.286.3.327 – volume: 38 start-page: 143 year: 2014 ident: ref_285 article-title: Association of vaspin with metabolic syndrome: The pivotal role of insulin resistance publication-title: Diabetes Metab. J. doi: 10.4093/dmj.2014.38.2.143 – volume: 267 start-page: R439 year: 1994 ident: ref_65 article-title: Aging and exercise training in skeletal muscle: Responses of glutathione and antioxidant enzyme systems publication-title: Am. J. Physiol. – volume: 32 start-page: 1345 year: 2011 ident: ref_191 article-title: Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehr112 – volume: 129 start-page: 4165 year: 2019 ident: ref_209 article-title: Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes publication-title: J. Clin. Investig. doi: 10.1172/JCI127308 – volume: 89 start-page: 381 year: 2009 ident: ref_279 article-title: Expression of omentin in adipose tissues in obese and type 2 diabetic patients publication-title: Zhonghua Yi Xue Za Zhi – volume: 24 start-page: 391 year: 2013 ident: ref_210 article-title: The regulation of ApoB metabolism by insulin publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2013.04.001 – volume: 1803 start-page: 1231 year: 2010 ident: ref_91 article-title: MicroRNAs: Synthesis, mechanism, function, and recent clinical trials publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2010.06.013 – volume: 375 start-page: 2215 year: 2010 ident: ref_9 article-title: Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies publication-title: Lancet doi: 10.1016/S0140-6736(10)60484-9 – volume: 11 start-page: 872 year: 2010 ident: ref_139 article-title: Mitochondrial fusion and fission in cell life and death publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm3013 – volume: 32 start-page: 309 year: 2012 ident: ref_143 article-title: Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.05603-11 – volume: 69 start-page: 204 year: 1993 ident: ref_14 article-title: Obesity, albuminuria and hypertension among Hong Kong Chinese with non-insulin-dependent diabetes mellitus (NIDDM) publication-title: Postgrad. Med. J. doi: 10.1136/pgmj.69.809.204 – volume: 404 start-page: 787 year: 2000 ident: ref_107 article-title: Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage publication-title: Nature doi: 10.1038/35008121 – volume: 117 start-page: 2621 year: 2007 ident: ref_261 article-title: Obesity-associated improvements in metabolic profile through expansion of adipose tissue publication-title: J. Clin. Investig. doi: 10.1172/JCI31021 – volume: 57 start-page: 1528 year: 2014 ident: ref_10 article-title: Genetic susceptibility to type 2 diabetes and obesity: From genome-wide association studies to rare variants and beyond publication-title: Diabetologia doi: 10.1007/s00125-014-3270-4 – volume: 114 start-page: 623 year: 2006 ident: ref_271 article-title: Adiponectin and coronary heart disease: A prospective study and meta-analysis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.618918 – volume: 7 start-page: 1764 year: 2013 ident: ref_32 article-title: Effect of Physical activity on Insulin Resistance, Inflammation and Oxidative Stress in Diabetes Mellitus publication-title: J. Clin. Diagn. Res. – volume: 155 start-page: 102 year: 2016 ident: ref_44 article-title: Activation of PKA and Epac proteins by cyclic AMP depletes intracellular calcium stores and reduces calcium availability for vasoconstriction publication-title: Life Sci. doi: 10.1016/j.lfs.2016.03.059 – volume: 32 start-page: S141 year: 2009 ident: ref_15 article-title: Search for Diabetes in Navajo youth: Prevalence, incidence, and clinical characteristics: The Search for Diabetes in Youth Study publication-title: Diabetes Care doi: 10.2337/dc09-S206 – volume: 260 start-page: 8783 year: 1985 ident: ref_215 article-title: Receptor-mediated uptake of remnant lipoproteins by cholesterol-loaded human monocyte-macrophages publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)39420-6 – volume: 46 start-page: 733 year: 2003 ident: ref_190 article-title: Diabetic dyslipidaemia: From basic research to clinical practice publication-title: Diabetologia doi: 10.1007/s00125-003-1111-y – volume: 38 start-page: 1203 year: 1989 ident: ref_87 article-title: Pathogenesis of diabetic retinopathy publication-title: Diabetes doi: 10.2337/diab.38.10.1203 – volume: 156 start-page: 1307 year: 1996 ident: ref_31 article-title: Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men publication-title: Arch. Intern. Med. doi: 10.1001/archinte.1996.00440110073010 – volume: 11 start-page: 1581 year: 2002 ident: ref_151 article-title: Type 2 diabetes is associated with a common mitochondrial variant: Evidence from a population-based case-control study publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/11.13.1581 – volume: 30 start-page: 1097 year: 2007 ident: ref_20 article-title: Rising incidence of type 2 diabetes in children in the U.K publication-title: Diabetes Care doi: 10.2337/dc06-1813 – volume: 375 start-page: 2369 year: 2016 ident: ref_71 article-title: The Human Intestinal Microbiome in Health and Disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1600266 – volume: 2007 start-page: 21976 year: 2007 ident: ref_108 article-title: Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries publication-title: Exp. Diabetes Res. doi: 10.1155/2007/21976 – volume: 384 start-page: 626 year: 2014 ident: ref_192 article-title: Triglycerides and cardiovascular disease publication-title: Lancet doi: 10.1016/S0140-6736(14)61177-6 – volume: 37 start-page: 1924 year: 1996 ident: ref_223 article-title: Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B publication-title: J. Lipid. Res. doi: 10.1016/S0022-2275(20)37557-X – volume: 68 start-page: 27 year: 2011 ident: ref_99 article-title: Stable transmission of reversible modifications: Maintenance of epigenetic information through the cell cycle publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-010-0505-5 – volume: 38 start-page: 2459 year: 2017 ident: ref_222 article-title: Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehx144 – volume: 454 start-page: 463 year: 2008 ident: ref_68 article-title: The role of exercise and PGC1alpha in inflammation and chronic disease publication-title: Nature doi: 10.1038/nature07206 – volume: 15 start-page: 385 year: 2017 ident: ref_128 article-title: Oxidative stress, protein damage and repair in bacteria publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2017.26 – volume: 359 start-page: 1577 year: 2008 ident: ref_84 article-title: 10-year follow-up of intensive glucose control in type 2 diabetes publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0806470 – volume: 67 start-page: 1923 year: 2018 ident: ref_90 article-title: Epigenetics and Epigenomics: Implications for Diabetes and Obesity publication-title: Diabetes doi: 10.2337/db18-0537 – volume: 6 start-page: 958 year: 2017 ident: ref_40 article-title: The dynamic plasticity of insulin production in beta-cells publication-title: Mol. Metab. doi: 10.1016/j.molmet.2017.04.010 – volume: 37 start-page: 969 year: 2017 ident: ref_196 article-title: Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.116.308834 – volume: 211 start-page: 353 year: 2010 ident: ref_203 article-title: Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2010.01.028 – volume: 7 start-page: 484 year: 2013 ident: ref_213 article-title: High-density lipoproteins: A consensus statement from the National Lipid Association publication-title: J. Clin. Lipidol. doi: 10.1016/j.jacl.2013.08.001 – volume: 63 start-page: 2158 year: 2014 ident: ref_23 article-title: Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity publication-title: Diabetes doi: 10.2337/db13-0949 – volume: 109 start-page: 1125 year: 2002 ident: ref_208 article-title: SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver publication-title: J. Clin. Investig. doi: 10.1172/JCI0215593 – volume: 103 start-page: 1057 year: 2001 ident: ref_272 article-title: Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages publication-title: Circulation doi: 10.1161/01.CIR.103.8.1057 – volume: 13 start-page: 14 year: 2018 ident: ref_280 article-title: Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters publication-title: J. Clin. Transl. Endocrinol. – volume: 423 start-page: 762 year: 2003 ident: ref_262 article-title: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects publication-title: Nature doi: 10.1038/nature01705 – volume: 290 start-page: E1253 year: 2006 ident: ref_273 article-title: Identification of omentin as a novel depot-specific adipokine in human adipose tissue: Possible role in modulating insulin action publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00572.2004 – volume: 970 start-page: 222 year: 1988 ident: ref_48 article-title: Effect of exogenous ATP upon inositol phosphate production, cationic fluxes and insulin release in pancreatic islet cells publication-title: Biochim. Biophys. Acta doi: 10.1016/0167-4889(88)90182-6 – volume: 47 start-page: 142 year: 2007 ident: ref_175 article-title: Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences publication-title: J. Hepatol. doi: 10.1016/j.jhep.2007.04.002 – volume: 52 start-page: 497 year: 2015 ident: ref_256 article-title: NETosis is induced by high glucose and associated with type 2 diabetes publication-title: Acta. Diabetol. doi: 10.1007/s00592-014-0676-x – volume: 121 start-page: 2118 year: 2011 ident: ref_42 article-title: Dynamics of insulin secretion and the clinical implications for obesity and diabetes publication-title: J. Clin. Investig. doi: 10.1172/JCI45680 – volume: 51 start-page: 1299 year: 2002 ident: ref_43 article-title: The ryanodine receptor calcium channel of beta-cells: Molecular regulation and physiological significance publication-title: Diabetes doi: 10.2337/diabetes.51.5.1299 – volume: 15 start-page: 18677 year: 2014 ident: ref_159 article-title: Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms151018677 – volume: 10 start-page: 293 year: 2014 ident: ref_185 article-title: Insulin resistance and hyperglycaemia in cardiovascular disease development publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2014.29 – volume: 13 start-page: 2051 year: 1999 ident: ref_121 article-title: Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss publication-title: FASEB J. doi: 10.1096/fasebj.13.14.2051 – volume: 371 start-page: 516 year: 1994 ident: ref_47 article-title: A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP publication-title: Nature doi: 10.1038/371516a0 – volume: 339 start-page: 229 year: 1998 ident: ref_178 article-title: Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199807233390404 – volume: 104 start-page: 787 year: 1999 ident: ref_3 article-title: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus publication-title: J. Clin. Investig. doi: 10.1172/JCI7231 – volume: 57 start-page: 133 year: 2012 ident: ref_129 article-title: The emerging challenge in diabetes: The “metabolic memory” publication-title: Vascul. Pharmacol. doi: 10.1016/j.vph.2012.05.005 – volume: 60 start-page: 517 year: 2011 ident: ref_254 article-title: Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue publication-title: Diabetes doi: 10.2337/db10-0266 – volume: 34 start-page: 247 year: 2012 ident: ref_74 article-title: Aging of the human metaorganism: The microbial counterpart publication-title: Age (Dordrecht) doi: 10.1007/s11357-011-9217-5 – volume: 277 start-page: E1130 year: 1999 ident: ref_120 article-title: Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss publication-title: Am. J. Physiol. – volume: 2018 start-page: 7514383 year: 2018 ident: ref_144 article-title: The Causal Role of Mitochondrial Dynamics in Regulating Insulin Resistance in Diabetes: Link through Mitochondrial Reactive Oxygen Species publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2018/7514383 – volume: 40 start-page: 1 year: 2017 ident: ref_66 article-title: New markers of insulin resistance in polycystic ovary syndrome publication-title: J. Endocrinol. Investig. doi: 10.1007/s40618-016-0523-8 – volume: 36 start-page: 574 year: 2013 ident: ref_17 article-title: Elevated rates of diabetes in Pacific Islanders and Asian subgroups: The Diabetes Study of Northern California (DISTANCE) publication-title: Diabetes Care doi: 10.2337/dc12-0722 – volume: 27 start-page: 1496 year: 2004 ident: ref_216 article-title: Lipids and lipoproteins in patients with type 2 diabetes publication-title: Diabetes Care doi: 10.2337/diacare.27.6.1496 – volume: 330 start-page: 962 year: 1994 ident: ref_146 article-title: A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199404073301403 – volume: 249 start-page: 218 year: 2012 ident: ref_130 article-title: The inflammation highway: Metabolism accelerates inflammatory traffic in obesity publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2012.01151.x – volume: 47 start-page: 276 year: 1998 ident: ref_150 article-title: New mitochondrial DNA homoplasmic mutations associated with Japanese patients with type 2 diabetes publication-title: Diabetes doi: 10.2337/diab.47.2.276 – volume: 41 start-page: 1174 year: 2003 ident: ref_186 article-title: Dyslipidemia in patients with type 2 diabetes. relationships between lipids, kidney disease and cardiovascular disease publication-title: Clin. Chem. Lab. Med. doi: 10.1515/CCLM.2003.181 – volume: 20 start-page: 28 year: 2018 ident: ref_54 article-title: Biosynthesis, structure, and folding of the insulin precursor protein publication-title: Diabetes Obes. Metab. doi: 10.1111/dom.13378 – volume: 8 start-page: 1031 year: 2018 ident: ref_263 article-title: Adiponectin Regulation and Function publication-title: Compr. Physiol. doi: 10.1002/cphy.c170046 – volume: 20 start-page: 11 year: 2018 ident: ref_93 article-title: MicroRNAs in islet hormone secretion publication-title: Diabetes Obes. Metab. doi: 10.1111/dom.13382 – volume: 58 start-page: 443 year: 2015 ident: ref_98 article-title: Epigenetic mechanisms in diabetic complications and metabolic memory publication-title: Diabetologia doi: 10.1007/s00125-014-3462-y – volume: 121 start-page: 91 year: 2014 ident: ref_78 article-title: The role of short-chain fatty acids in health and disease publication-title: Adv. Immunol. doi: 10.1016/B978-0-12-800100-4.00003-9 – volume: 42 start-page: 406 year: 2015 ident: ref_53 article-title: Insulin secretion from beta cells within intact islets: Location matters publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/1440-1681.12368 – volume: 109 start-page: 361 year: 2001 ident: ref_149 article-title: Association of the mitochondrial DNA 5178A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients publication-title: Exp. Clin. Endocrinol. Diabetes doi: 10.1055/s-2001-17407 – volume: 31 start-page: 283 year: 1982 ident: ref_226 article-title: Nonenzymatic glucosylation of low-density lipoprotein alters its biologic activity publication-title: Diabetes doi: 10.2337/diab.31.4.283 – volume: 47 start-page: 1093 year: 2006 ident: ref_200 article-title: Metabolic syndrome: Connecting and reconciling cardiovascular and diabetes worlds publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2005.11.046 – volume: 90 start-page: 1029 year: 2012 ident: ref_258 article-title: Adipokines and the cardiovascular system: Mechanisms mediating health and disease publication-title: Can. J. Physiol. Pharmacol. doi: 10.1139/y2012-053 – volume: 28 start-page: 497 year: 2017 ident: ref_169 article-title: Unraveling the Regulation of Hepatic Metabolism by Insulin publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2017.03.003 – volume: 19 start-page: 390 year: 1996 ident: ref_187 article-title: Acute effects of insulin in the control of VLDL production in humans. Implications for the insulin-resistant state publication-title: Diabetes Care doi: 10.2337/diacare.19.4.390 – volume: 14 start-page: 839 year: 1991 ident: ref_201 article-title: Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesis publication-title: Diabetes Care doi: 10.2337/diacare.14.9.839 – volume: 102 start-page: 401 year: 2008 ident: ref_112 article-title: Role of mitochondrial dysfunction in insulin resistance publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.107.165472 – volume: 14 start-page: 575 year: 2011 ident: ref_183 article-title: Insulin resistance, hyperglycemia, and atherosclerosis publication-title: Cell. Metab. doi: 10.1016/j.cmet.2011.07.015 – ident: ref_274 doi: 10.3390/nu11112664 – ident: ref_5 – volume: 58 start-page: 1229 year: 2009 ident: ref_103 article-title: Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail publication-title: Diabetes doi: 10.2337/db08-1666 – volume: 24 start-page: R453 year: 2014 ident: ref_127 article-title: ROS function in redox signaling and oxidative stress publication-title: Curr. Biol. doi: 10.1016/j.cub.2014.03.034 – volume: 91 start-page: 10771 year: 1994 ident: ref_118 article-title: Oxidative damage and mitochondrial decay in aging publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.91.23.10771 – volume: 292 start-page: 1188 year: 2004 ident: ref_30 article-title: Relationship of physical activity vs body mass index with type 2 diabetes in women publication-title: JAMA doi: 10.1001/jama.292.10.1188 – volume: 3 start-page: 1004 year: 2015 ident: ref_18 article-title: Type 2 diabetes in migrant south Asians: Mechanisms, mitigation, and management publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/S2213-8587(15)00326-5 – volume: 204 start-page: 105 year: 2009 ident: ref_211 article-title: Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2008.07.046 – volume: 625 start-page: 64 year: 2016 ident: ref_106 article-title: Epigenetic changes in diabetes publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2016.04.046 – volume: 57 start-page: 2943 year: 2008 ident: ref_126 article-title: Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients publication-title: Diabetes doi: 10.2337/db08-0391 – volume: 22 start-page: 49 year: 2012 ident: ref_245 article-title: Inflammation and haemostasis publication-title: Biochem. Med. (Zagreb.) doi: 10.11613/BM.2012.006 – volume: 100 start-page: 8466 year: 2003 ident: ref_124 article-title: Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1032913100 – volume: 78 start-page: 1189 year: 2016 ident: ref_154 article-title: The Effects of Insulin Resistance on Individual Tissues: An Application of a Mathematical Model of Metabolism in Humans publication-title: Bull. Math. Biol. doi: 10.1007/s11538-016-0181-1 – volume: 116 start-page: 11S year: 2004 ident: ref_180 article-title: Correlation between cardiovascular disease and diabetes mellitus: Current concepts publication-title: Am. J. Med. doi: 10.1016/j.amjmed.2003.10.016 – volume: 106 start-page: 453 year: 2000 ident: ref_234 article-title: Insulin resistance and cardiovascular disease publication-title: J. Clin. Investig. doi: 10.1172/JCI10762 – volume: 277 start-page: 17377 year: 2002 ident: ref_206 article-title: Complexity in the secretory pathway: The assembly and secretion of apolipoprotein B-containing lipoproteins publication-title: J. Biol. Chem. doi: 10.1074/jbc.R100068200 – volume: 17 start-page: 535 year: 2016 ident: ref_24 article-title: Type 2 diabetes: Genetic data sharing to advance complex disease research publication-title: Nat. Rev. Genet. doi: 10.1038/nrg.2016.56 – volume: 35 start-page: 1171 year: 2007 ident: ref_170 article-title: Insulin action on the liver in vivo publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0351171 – volume: 124 start-page: 1602 year: 2011 ident: ref_230 article-title: Adipose modulation of high-density lipoprotein cholesterol: Implications for obesity, high-density lipoprotein metabolism, and cardiovascular disease publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.111.058453 – ident: ref_156 doi: 10.1201/b15306 – volume: 94 start-page: 3171 year: 2009 ident: ref_240 article-title: Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2008-2534 – volume: 536 start-page: 41 year: 2016 ident: ref_21 article-title: The genetic architecture of type 2 diabetes publication-title: Nature doi: 10.1038/nature18642 – volume: 19 start-page: 2474 year: 1999 ident: ref_198 article-title: Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.19.10.2474 – volume: 32 start-page: 2045 year: 2012 ident: ref_248 article-title: Inflammation in atherosclerosis publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.108.179705 – volume: 95 start-page: 8 year: 2002 ident: ref_158 article-title: Cellular mechanism of insulin resistance in skeletal muscle publication-title: J. R Soc. Med. – ident: ref_145 doi: 10.1371/journal.pone.0092753 – volume: 35 start-page: 670 year: 2016 ident: ref_283 article-title: Modulatory Role of Omentin-1 in Inflammation: Cytokines and Dietary Intake publication-title: J. Am. Coll. Nutr. doi: 10.1080/07315724.2015.1126207 – volume: 8 start-page: 222 year: 2011 ident: ref_218 article-title: HDL and cardiovascular disease: Atherogenic and atheroprotective mechanisms publication-title: Nat. Rev. Cardiol. doi: 10.1038/nrcardio.2010.222 – volume: 364 start-page: 937 year: 2004 ident: ref_235 article-title: Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study publication-title: Lancet doi: 10.1016/S0140-6736(04)17018-9 – volume: 36 start-page: 1413 year: 2013 ident: ref_25 article-title: Gene-environment and gene-treatment interactions in type 2 diabetes: Progress, pitfalls, and prospects publication-title: Diabetes Care doi: 10.2337/dc12-2211 – volume: 49 start-page: 1269 year: 2000 ident: ref_148 article-title: A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes publication-title: Diabetes doi: 10.2337/diabetes.49.7.1269 – volume: 24 start-page: 327 year: 1998 ident: ref_241 article-title: Von Willebrand factor in diabetic angiopathy publication-title: Diabetes Metab. – volume: 66 start-page: 815 year: 2017 ident: ref_165 article-title: Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study publication-title: Diabetes doi: 10.2337/db16-1167 – volume: 39 start-page: 668 year: 2016 ident: ref_11 article-title: Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study publication-title: Diabetes Care doi: 10.2337/dc15-2439 – volume: 90 start-page: 11G year: 2002 ident: ref_157 article-title: Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus publication-title: Am. J. Cardiol. doi: 10.1016/S0002-9149(02)02554-7 – volume: 27 start-page: 436 year: 2011 ident: ref_242 article-title: Macrovascular angiopathy in children and adolescents with type 1 diabetes publication-title: Diabetes Metab. Res. Rev. doi: 10.1002/dmrr.1195 – volume: 15 start-page: 585 year: 2012 ident: ref_133 article-title: A ceramide-centric view of insulin resistance publication-title: Cell. Metab. doi: 10.1016/j.cmet.2012.04.002 – volume: 156 start-page: 2019 year: 2015 ident: ref_264 article-title: Adiponectin-mediated antilipotoxic effects in regenerating pancreatic islets publication-title: Endocrinology doi: 10.1210/en.2015-1066 – volume: 57 start-page: 801 year: 2008 ident: ref_278 article-title: Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: Ex vivo and in vivo regulation of omentin-1 by insulin and glucose publication-title: Diabetes doi: 10.2337/db07-0990 – volume: 11 start-page: 467 year: 2010 ident: ref_140 article-title: Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance publication-title: Cell. Metab. doi: 10.1016/j.cmet.2010.04.005 – volume: 481 start-page: 463 year: 2012 ident: ref_67 article-title: A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis publication-title: Nature doi: 10.1038/nature10777 – volume: 7 start-page: 44986 year: 2017 ident: ref_94 article-title: Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell publication-title: Sci. Rep. doi: 10.1038/srep44986 – volume: 37 start-page: S65 year: 1994 ident: ref_39 article-title: Proinsulin processing in the regulated and the constitutive secretory pathway publication-title: Diabetologia doi: 10.1007/BF00400828 – volume: 16 start-page: 375 year: 2015 ident: ref_115 article-title: A giant molecular proton pump: Structure and mechanism of respiratory complex I publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm3997 – volume: 80 start-page: 719 year: 1989 ident: ref_197 article-title: Lipoproteins and the pathogenesis of atherosclerosis publication-title: Circulation doi: 10.1161/01.CIR.80.3.719 – volume: 106 start-page: 5813 year: 2009 ident: ref_96 article-title: miR-375 maintains normal pancreatic alpha- and beta-cell mass publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0810550106 – volume: 7 start-page: 304 year: 2013 ident: ref_227 article-title: Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association publication-title: J. Clin. Lipidol. doi: 10.1016/j.jacl.2013.04.001 – volume: 1853 start-page: 2784 year: 2015 ident: ref_137 article-title: Selective removal of mitochondria via mitophagy: Distinct pathways for different mitochondrial stresses publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2015.03.013 – volume: 94 start-page: 350 year: 1993 ident: ref_224 article-title: Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B publication-title: Am. J. Med. doi: 10.1016/0002-9343(93)90144-E – volume: 363 start-page: 2339 year: 2010 ident: ref_22 article-title: Genomics, type 2 diabetes, and obesity publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0906948 – volume: 58 start-page: 773 year: 2009 ident: ref_6 article-title: From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus publication-title: Diabetes doi: 10.2337/db09-9028 – volume: 121 start-page: 1347 year: 2010 ident: ref_231 article-title: Adipocyte modulation of high-density lipoprotein cholesterol publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.897330 – volume: 362 start-page: 513 year: 2002 ident: ref_172 article-title: The glucose-6-phosphatase system publication-title: Biochem. J. doi: 10.1042/bj3620513 – volume: 98 start-page: 117 year: 2018 ident: ref_41 article-title: Pancreatic beta-Cell Electrical Activity and Insulin Secretion: Of Mice and Men publication-title: Physiol. Rev. doi: 10.1152/physrev.00008.2017 – volume: 79 start-page: 155 year: 2010 ident: ref_101 article-title: Reversal of histone methylation: Biochemical and molecular mechanisms of histone demethylases publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.78.070907.103946 – volume: 8 start-page: 1882 year: 2017 ident: ref_76 article-title: Gut Microbiota Dysbiosis Drives and Implies Novel Therapeutic Strategies for Diabetes Mellitus and Related Metabolic Diseases publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.01882 – volume: 47 start-page: 668 year: 2008 ident: ref_266 article-title: Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells publication-title: Hepatology doi: 10.1002/hep.21995 – volume: 50 start-page: 1523 year: 2007 ident: ref_85 article-title: Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling publication-title: Diabetologia doi: 10.1007/s00125-007-0684-2 – volume: 4 start-page: 37 year: 2013 ident: ref_35 article-title: Beta cell dysfunction and insulin resistance publication-title: Front. Endocrinol. (Lausanne) doi: 10.3389/fendo.2013.00037 – volume: 40 start-page: 99 year: 2015 ident: ref_111 article-title: Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease publication-title: Interdiscip. Top Gerontol. – volume: 23 start-page: 804 year: 2017 ident: ref_153 article-title: Insulin action and resistance in obesity and type 2 diabetes publication-title: Nat. Med. doi: 10.1038/nm.4350 – volume: 37 start-page: 667 year: 1988 ident: ref_160 article-title: Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM publication-title: Diabetes doi: 10.2337/diab.37.6.667 – volume: 8 start-page: 731 year: 2002 ident: ref_260 article-title: Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 publication-title: Nat. Med. doi: 10.1038/nm724 – volume: 12 start-page: 643 year: 2018 ident: ref_70 article-title: Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus publication-title: Diabetes Metab. Syndr. doi: 10.1016/j.dsx.2018.04.025 – volume: 18 start-page: 282 year: 2004 ident: ref_109 article-title: Reversal of hyperglycemia and diabetic nephropathy: Effect of reinstitution of good metabolic control on oxidative stress in the kidney of diabetic rats publication-title: J. Diabetes Complicat. doi: 10.1016/j.jdiacomp.2004.03.002 – volume: 37 start-page: 345 year: 2013 ident: ref_255 article-title: Molecular mechanisms linking diabetes to the accelerated development of atherosclerosis publication-title: Can. J. Diabetes doi: 10.1016/j.jcjd.2013.06.001 – volume: 98 start-page: 4899 year: 2013 ident: ref_69 article-title: Circulating irisin in relation to insulin resistance and the metabolic syndrome publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2013-2373 – volume: 109 start-page: 5523 year: 2012 ident: ref_142 article-title: Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1108220109 – volume: 21 start-page: 1 year: 2006 ident: ref_199 article-title: Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute scientific statement publication-title: Curr. Opin. Cardiol. doi: 10.1097/01.hco.0000200416.65370.a0 – volume: 42 start-page: S29 year: 2019 ident: ref_63 article-title: Prevention or Delay of Type 2 Diabetes: Standards of Medical Care in Diabetes-2019 publication-title: Diabetes Care doi: 10.2337/dc19-S003 – volume: 90 start-page: 5113 year: 1993 ident: ref_45 article-title: Expression cloning of an ATP receptor from mouse neuroblastoma cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.90.11.5113 – volume: 46 start-page: 567 year: 2013 ident: ref_173 article-title: CREB and FoxO1: Two transcription factors for the regulation of hepatic gluconeogenesis publication-title: BMB Rep. doi: 10.5483/BMBRep.2013.46.12.248
SSID	ssj0023259
Score	2.727438
SecondaryResourceType	review_article
Snippet	Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by...
SourceID	pubmedcentral proquest pubmed crossref
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	6275
SubjectTerms	Animals Blood Glucose - metabolism Cardiovascular disease Diabetes Diabetes Mellitus, Type 2 - physiopathology Epidemiology Ethnicity Family medical history Genomes Glucose Homeostasis Humans Hyperglycemia Inflammation Insulin resistance Insulin Secretion Lifestyles Metabolism Mortality Musculoskeletal system Obesity Pathogenesis Pathophysiology Physiology Population Review Risk factors
Title	Pathophysiology of Type 2 Diabetes Mellitus
URI	https://www.ncbi.nlm.nih.gov/pubmed/32872570 https://www.proquest.com/docview/2440180571 https://www.proquest.com/docview/2439630590 https://pubmed.ncbi.nlm.nih.gov/PMC7503727
Volume	21
WOSCitedRecordID	wos000569977700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: ProQuest Central (New) (NC LIVE) customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: BENPR dateStart: 20000301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection (NC LIVE) customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: 7X7 dateStart: 20000301 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: PIMPY dateStart: 20000301 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Research Library (NC LIVE) customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: M2O dateStart: 20000301 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fT9swED6NAtJexvgdYFWQ4AlZJHZSx0_TNhVtDy0VAqk8RbYTiyJIGGmR9t_jS9xAmbYXXiI5vijO2bHvzufvAzhSITWZMZr0lOAkUokhguWaRDpOtNKS5T1dk03w4TAZj8XIBdwql1Y5nxPriTorNcbIT-0yhFhTMQ-_PvwmyBqFu6uOQmMJlhGpLOrA8vf-cHTRulyM1nRpoV2FSC8WvSb1nVlH_3Rye1_ZhzjC9C4uSn9Zmm8TJl-tQGdr7237Z_jkbE__WzNY1uFDXmzAasNG-WcTEK7_pqxDHfUdvzQ-uqk-9V3eTOUPEL9zOqu24Oqsf_njJ3FcCkRHPJmS2MQmYDHX1hmOpf3oPEpElnFhEFiSiZAqEwZaMYVc6cp6OVIoLjNNMy5VwNg2dIqyyHfBF5IqtNKU5DTiMkiyIAqj2Ag85ioT7sHJXJmpdkDjyHdxl1qHA1Wfvla9B8et9EMDsPEPuYO5blP3m1Xpi2I9OGyr7Q-Cux6yyMsZyjA7yeAZWw92mm5sX8Ssv4g0fh7whQ5uBRB8e7GmmNzUINy4_2ttv73_N2sfPlJ00DEIHRxAZ_o4y7_Ain6aTqrHLizxMa-vSdeNXFsa0HNbGv0ajK6fAWlH97k
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LT9wwEB4hKIILbXkGKA0SnCprEzuJ4wOqEC0CAaseQNpbajuxdquSANkF8af4jXjyWFgqeuPANR4pUWY8L4-_D2BH-dSkxmgSKcFJoGJDBMs0CXQYa6UlyyJdkU3wbjfu9cSvKXho78LgWGXrEytHnRYae-QdG4YQayrk_vera4KsUXi62lJo1GZxkt3f2ZKt3Dv-YfW7S-nhz_ODI9KwChAd8HhIQhMaj4Vc27IwlNYXZEEs0pQLgxCLTPhUGd_TiilkDVc235dCcZlqmnKpPGyAWpc_Y_04xxEy3nsq8BityNl8G_NIFIqoHrRnTHidwZ_L0tZaHEGBJ0PgP3nty_HMZ_Hu8ON7-1OfYKHJrN39eit8hqksX4TZmmvzfgmQjKBfVI2c6olbGBeLcJe6zVRQ6Z4hOulwVC7DxZt86QpM50WerYErJFWYgyrJacClF6de4AehEXiJV8bcgW-t8hLdwKgjm8ffxJZTqOrkuaod2B1LX9XwIa_Ibba6TBonUiZPinRge7xstz-e6cg8K0Yow6wLxRvEDqzWZjN-EbPVMJIUOsAnDGosgNDikyv5oF9BjOPpts1s1___WV9h7uj87DQ5Pe6ebMA8xVYEttu9TZge3oyyL_BB3w4H5c1WtU9c-P3W5vYIgolNgQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3dT9RAEJ8QQMOL4ncRtCbyZDbX7ra33QdjFLhI0MvFaMJb3d12wxFtkd5J-Nf465jpF5xE33jwtTtJm87sfO3s7wfw2oTcZc5ZNjRKssgkjimRWxbZOLHGapEPbU02Icfj5PBQTZbgorsLQ2OVnU-sHXVWWuqRDzAMEdZULMOBa8ciJrujdye_GDFI0UlrR6fRmMhBfn6G5Vv1dn8Xdb3N-Wjv685H1jIMMBvJZMZiF7tAxNJiiRhr9At5lKgsk8oR3KJQITcuDKwRhhjEDeb-WhmpM8szqU1AzVB0_ysSkwzcXSsf9saTL325J3hN1RZiBGTDWA2bsXshVDCYHv-ssPKSBBG8GBBvZLl_Dmtei36j-__zf1uHe23O7b9vNskDWMqLh3CnYeE8fwREU3BU1i2e-olfOp_Kc5_77bxQ5X8m3NLZvHoM327lS5_AclEW-TPwleaGslOjJY-kDpIsiMIodoqu9-pEevCmU2RqW4B14vn4kWKhRWpPr6vdg-1e-qQBFvmL3Gan17R1L1V6pVQPXvXL6BjotEcXeTknGYHOle4We_C0MaH-RQLrZKIv9EAuGFcvQKDjiyvF9KgGH6dzb8x5N_79WS_hLlpZ-ml_fPAc1jj1KKgPH2zC8ux0nm_Bqv09m1anL9pN48P327a3SwlgV6I
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pathophysiology+of+Type+2+Diabetes+Mellitus&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Galicia-Garcia%2C+Unai&rft.au=Benito-Vicente%2C+Asier&rft.au=Jebari%2C+Shifa&rft.au=Larrea-Sebal%2C+Asier&rft.date=2020-08-30&rft.pub=MDPI+AG&rft.issn=1661-6596&rft.eissn=1422-0067&rft.volume=21&rft.issue=17&rft.spage=6275&rft_id=info:doi/10.3390%2Fijms21176275&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon