NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology

Development of novel vaccines and treatment approaches against tuberculosis are hampered by limited knowledge of what constitutes a protective immune response against Mycobacterium tuberculosis ( Mtb ). Granulomas are organized immune aggregates that form in the lung in response to mycobacterial inf...

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Vydáno v:PLoS pathogens Ročník 21; číslo 8; s. e1012980
Hlavní autoři: Niewold, Paula, IJsselsteijn, Marieke E., Dijkman, Karin, de Miranda, Noel, Ottenhoff, Tom H. M., Verreck, Frank A. W., Joosten, Simone A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 01.08.2025
Public Library of Science (PLoS)
Témata:
Animal pathology
Animals
Antibiotics
Biology and Life Sciences
Cell Communication - immunology
Cells
Composition
Correlation
Cytometry
Granuloma
Granuloma - immunology
Granuloma - microbiology
Granuloma - pathology
Granulomas
Host-Pathogen Interactions - immunology
Immune response
Immune system
Infections
Killer Cells, Natural - immunology
Killer Cells, Natural - pathology
Lung - immunology
Lung - microbiology
Lung - pathology
Lungs
Lymphocytes
Macaca mulatta
Macrophages
Macrophages - immunology
Macrophages - pathology
Medicine and Health Sciences
Microenvironments
Mycobacterium tuberculosis - immunology
Natural killer cells
Neutrophils
Pathology
Research and Analysis Methods
Tuberculosis
Tuberculosis - immunology
Tuberculosis - pathology
Tuberculosis, Pulmonary - immunology
Tuberculosis, Pulmonary - pathology
Vaccines
ISSN:1553-7374, 1553-7366, 1553-7374
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Shrnutí:Development of novel vaccines and treatment approaches against tuberculosis are hampered by limited knowledge of what constitutes a protective immune response against Mycobacterium tuberculosis ( Mtb ). Granulomas are organized immune aggregates that form in the lung in response to mycobacterial infection and are an important site of pathogen-host interaction. The composition and cellular microenvironment within the granuloma impacts the bacterial control capacity. To identify protective responses in granulomas, imaging mass cytometry was used to study archived lung tissue from low dose Mtb -infected non-human primates presenting with various levels of disease. This approach revealed that granuloma composition is correlated with the severity of lung pathology. Granulomas of animals with limited lung pathology were enriched for NK cells showing increased interactions with tissue macrophages. This work improves our understanding of local immune interactions in the lung and how these correlate with severity of tuberculosis disease.
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The authors have declared no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1012980