NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology

Development of novel vaccines and treatment approaches against tuberculosis are hampered by limited knowledge of what constitutes a protective immune response against Mycobacterium tuberculosis ( Mtb ). Granulomas are organized immune aggregates that form in the lung in response to mycobacterial inf...

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Veröffentlicht in:	PLoS pathogens Jg. 21; H. 8; S. e1012980
Hauptverfasser:	Niewold, Paula, IJsselsteijn, Marieke E., Dijkman, Karin, de Miranda, Noel, Ottenhoff, Tom H. M., Verreck, Frank A. W., Joosten, Simone A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.08.2025 Public Library of Science (PLoS)
Schlagworte:	Animal pathology Animals Antibiotics Biology and Life Sciences Cell Communication - immunology Cells Composition Correlation Cytometry Granuloma Granuloma - immunology Granuloma - microbiology Granuloma - pathology Granulomas Host-Pathogen Interactions - immunology Immune response Immune system Infections Killer Cells, Natural - immunology Killer Cells, Natural - pathology Lung - immunology Lung - microbiology Lung - pathology Lungs Lymphocytes Macaca mulatta Macrophages Macrophages - immunology Macrophages - pathology Medicine and Health Sciences Microenvironments Mycobacterium tuberculosis - immunology Natural killer cells Neutrophils Pathology Research and Analysis Methods Tuberculosis Tuberculosis - immunology Tuberculosis - pathology Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - pathology Vaccines
ISSN:	1553-7374, 1553-7366, 1553-7374
Online-Zugang:	Volltext
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