HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase

DNA damage tolerance is regulated at least in part at the level of proliferating cell nuclear antigen (PCNA) ubiquitination. Monoubiquitination (PCNA-Ub) at lysine residue 164 (K164) stimulates error-prone translesion synthesis (TLS), Rad5-dependent polyubiquitination (PCNA-Ub n) stimulates error-fr...

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Bibliographic Details
Published in:	DNA repair Vol. 10; no. 4; pp. 438 - 444
Main Authors:	Krijger, Peter H.L., Lee, Kyoo-Young, Wit, Niek, van den Berk, Paul C.M., Wu, Xiaoli, Roest, Henk P., Maas, Alex, Ding, Hao, Hoeijmakers, Jan H.J., Myung, Kyungjae, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 03.04.2011 Elsevier
Subjects:	Animals B-Lymphocytes - drug effects B-Lymphocytes - metabolism Bacteriology Biological and medical sciences Cell Survival - drug effects Cell Survival - genetics Cell Survival - radiation effects Cross-Linking Reagents - pharmacology DNA Helicases - deficiency DNA Helicases - genetics DNA Helicases - metabolism Embryonic Stem Cells - metabolism Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Gene Order Gene Targeting Growth, nutrition, cell differenciation HLTF Immunoglobulin Class Switching - drug effects Lipopolysaccharides - pharmacology Mice Mice, Knockout Microbiology Molecular and cellular biology Molecular genetics Mutagenesis. Repair PCNA Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism RAD5 SHPRH Somatic hypermutation Somatic Hypermutation, Immunoglobulin - genetics Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Translesion synthesis Ubiquitin-Protein Ligases - metabolism Ubiquitination - genetics Ubiquitination - physiology Ubiquitination - radiation effects Ultraviolet Rays - adverse effects SHPRH Somatic hypermutation PCNA Translesion synthesis RAD5 HLTF Immunoglobulins Carbon-nitrogen ligases Enzyme Survival Ligases DNA Repair Ubiquitin-protein ligase
ISSN:	1568-7864, 1568-7856, 1568-7856
Online Access:	Get full text
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