Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This article reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their...

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Published in:Biomolecules (Basel, Switzerland) Vol. 10; no. 1; p. 47
Main Authors: Khan, Tariq, Ali, Muhammad, Khan, Ajmal, Nisar, Parveen, Jan, Sohail Ahmad, Afridi, Shakeeb, Shinwari, Zabta Khan
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 27.12.2019
MDPI
Subjects:
Animal models
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Apoptosis
Blood cancer
Breast
Cancer
Cancer therapies
cell lines
Cell Proliferation - drug effects
Cervix
Colon
Dietary supplements
Disease Models, Animal
DNA damage
Herbal Medicine
Herbs
Humans
in vivo
Leukemia
Literature reviews
Lung cancer
Medicinal plants
Medicine
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Pharmaceutical industry
Phytochemicals
Phytochemicals - chemistry
Phytochemicals - pharmacology
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Review
Secondary metabolites
Tumor cell lines
apoptosis
cancer
in vivo
cell lines
herbs
ISSN:2218-273X, 2218-273X
Online Access:Get full text
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Abstract The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This article reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring more plants, their active compounds, and the mechanism of anticancer actions for use as standard herbal medicine.
AbstractList The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This article reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring more plants, their active compounds, and the mechanism of anticancer actions for use as standard herbal medicine.
The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This article reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring more plants, their active compounds, and the mechanism of anticancer actions for use as standard herbal medicine.The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This article reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring more plants, their active compounds, and the mechanism of anticancer actions for use as standard herbal medicine.
Author Ali, Muhammad
Afridi, Shakeeb
Jan, Sohail Ahmad
Nisar, Parveen
Shinwari, Zabta Khan
Khan, Ajmal
Khan, Tariq
AuthorAffiliation 1 Department of Biotechnology, University of Malakand, Chakdara 18800, Pakistan
4 Department of Biotechnology, Hazara University, Mansehra 21120, Pakistan; sjan.parc@gmail.com
5 National Council for Tibb, Islamabad, Pakistan
3 Department of Zoology, University of Buner, Sowari 17290, Pakistan; ajmal.sci@gmail.com
2 Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan; parveennisar@yahoo.com (P.N.); shakeebafridi@outlook.com (S.A.); shinwari2008@gmail.com (Z.K.S.)
AuthorAffiliation_xml – name: 1 Department of Biotechnology, University of Malakand, Chakdara 18800, Pakistan
– name: 3 Department of Zoology, University of Buner, Sowari 17290, Pakistan; ajmal.sci@gmail.com
– name: 5 National Council for Tibb, Islamabad, Pakistan
– name: 2 Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan; parveennisar@yahoo.com (P.N.); shakeebafridi@outlook.com (S.A.); shinwari2008@gmail.com (Z.K.S.)
– name: 4 Department of Biotechnology, Hazara University, Mansehra 21120, Pakistan; sjan.parc@gmail.com
Author_xml – sequence: 1
  givenname: Tariq
  orcidid: 0000-0002-9194-9240
  surname: Khan
  fullname: Khan, Tariq
– sequence: 2
  givenname: Muhammad
  orcidid: 0000-0002-7835-0663
  surname: Ali
  fullname: Ali, Muhammad
– sequence: 3
  givenname: Ajmal
  orcidid: 0000-0001-9703-2428
  surname: Khan
  fullname: Khan, Ajmal
– sequence: 4
  givenname: Parveen
  surname: Nisar
  fullname: Nisar, Parveen
– sequence: 5
  givenname: Sohail Ahmad
  orcidid: 0000-0001-9473-5507
  surname: Jan
  fullname: Jan, Sohail Ahmad
– sequence: 6
  givenname: Shakeeb
  surname: Afridi
  fullname: Afridi, Shakeeb
– sequence: 7
  givenname: Zabta Khan
  surname: Shinwari
  fullname: Shinwari, Zabta Khan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31892257$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords apoptosis
cancer
in vivo
cell lines
herbs
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Snippet The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine...
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StartPage 47
SubjectTerms Animal models
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Apoptosis
Blood cancer
Breast
Cancer
Cancer therapies
cell lines
Cell Proliferation - drug effects
Cervix
Colon
Dietary supplements
Disease Models, Animal
DNA damage
Herbal Medicine
Herbs
Humans
in vivo
Leukemia
Literature reviews
Lung cancer
Medicinal plants
Medicine
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Pharmaceutical industry
Phytochemicals
Phytochemicals - chemistry
Phytochemicals - pharmacology
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Review
Secondary metabolites
Tumor cell lines
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