TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression

Increased expression of transketolase (TKT) and its isoform transketolase-like-1 (TKTL1) has been related to the malignant leukemia phenotype through promoting an increase in the non-oxidative branch of the pentose phosphate pathway (PPP). Recently, it has also been described that TKTL1 can have a r...

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Veröffentlicht in:	International journal of molecular sciences Jg. 23; H. 7; S. 3574
Hauptverfasser:	Baptista, Inês, Karakitsou, Effrosyni, Cazier, Jean-Baptiste, Günther, Ulrich L., Marin, Silvia, Cascante, Marta
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 25.03.2022 MDPI
Schlagworte:	Adaptation Cancer therapies Cell culture Cell growth Dehydrogenases Enzymes Gene expression Glucose Glucose - metabolism Glucosephosphate Dehydrogenase - genetics Glucosephosphate Dehydrogenase - metabolism Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humans Hypoxia Kinases Leukemia Leukemia, Myeloid, Acute Metabolism Metabolites Pentose Phosphate Pathway - genetics Transketolase - genetics Transketolase - metabolism AML glucose-6-phosphate dehydrogenase hypoxia leukemia transcriptomics metabolism glyceraldehyde-3-phosphate dehydrogenase transketolase-like 1 pentose phosphate pathway
ISSN:	1422-0067, 1661-6596, 1422-0067
Online-Zugang:	Volltext
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