The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a...

Full description

Saved in:

Bibliographic Details
Published in:	Beilstein journal of nanotechnology Vol. 10; no. 1; pp. 901 - 911
Main Authors:	Ain, Qura Tul, Haq, Samina Hyder, Alshammari, Abeer, Al-Mutlaq, Moudhi Abdullah, Anjum, Muhammad Naeem
Format:	Journal Article
Language:	English
Published:	Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 2019 Beilstein-Institut
Subjects:	Acids Antioxidants Brain Cancer therapies Catalase Chemotherapy Drug delivery systems Enzymes Fourier transforms Free radicals Full Research Paper Glutathione Graphene Graphite In vivo methods and tests Kidneys Lipids nano-graphene oxide nanomedicine Nanoscience Nanotechnology Organs Oxidation Oxidative stress PEGylation Peroxides Photon correlation spectroscopy Polyethylene glycol Scavenging Size distribution Spectrum analysis Superoxide dismutase Tissue engineering Transmission electron microscopy X-ray diffraction Saudi Arabia nano-graphene oxide nanomedicine PEGylation oxidative stress
ISSN:	2190-4286, 2190-4286
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a modified Hummer's method and were characterized by X-ray diffraction (XRD), ultraviolet–visible spectroscopy (UV), and transmission electron microscopy (TEM). The method of Zhang was adopted for cracking of GOS. Then nano-graphene oxide was PEGylated with polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and a decrease in free radical scavenging enzymes in organs were observed. Our results indicated that the treatment with PEG-nGO caused an increased OS to the organs in the first few hours of treatment. However, the liver completely recovered from the OS after 4 h. Brain, heart and kidneys showed an increased OS even after 4 h. In conclusion increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys.
AbstractList	Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a modified Hummer's method and were characterized by X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV), and transmission electron microscopy (TEM). The method of Zhang was adopted for cracking of GOS. Then nano-graphene oxide was PEGylated with polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and a decrease in free radical scavenging enzymes in organs were observed. Our results indicated that the treatment with PEG-nGO caused an increased OS to the organs in the first few hours of treatment. However, the liver completely recovered from the OS after 4 h. Brain, heart and kidneys showed an increased OS even after 4 h. In conclusion increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys.Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a modified Hummer's method and were characterized by X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV), and transmission electron microscopy (TEM). The method of Zhang was adopted for cracking of GOS. Then nano-graphene oxide was PEGylated with polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and a decrease in free radical scavenging enzymes in organs were observed. Our results indicated that the treatment with PEG-nGO caused an increased OS to the organs in the first few hours of treatment. However, the liver completely recovered from the OS after 4 h. Brain, heart and kidneys showed an increased OS even after 4 h. In conclusion increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys. Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a modified Hummer's method and were characterized by X-ray diffraction (XRD), ultraviolet–visible spectroscopy (UV), and transmission electron microscopy (TEM). The method of Zhang was adopted for cracking of GOS. Then nano-graphene oxide was PEGylated with polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and a decrease in free radical scavenging enzymes in organs were observed. Our results indicated that the treatment with PEG-nGO caused an increased OS to the organs in the first few hours of treatment. However, the liver completely recovered from the OS after 4 h. Brain, heart and kidneys showed an increased OS even after 4 h. In conclusion increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys.
Author	Alshammari, Abeer Haq, Samina Hyder Ain, Qura Tul Al-Mutlaq, Moudhi Abdullah Anjum, Muhammad Naeem
AuthorAffiliation	1 Department of Physics, The Islamia University of Bahawalpur, Pakistan 2 Department of Physics and Astronomy, King Saud University, Kingdom of Saudi Arabia 3 Department of Biochemistry, King Saud University, Kingdom of Saudi Arabia
AuthorAffiliation_xml	– name: 2 Department of Physics and Astronomy, King Saud University, Kingdom of Saudi Arabia – name: 3 Department of Biochemistry, King Saud University, Kingdom of Saudi Arabia – name: 1 Department of Physics, The Islamia University of Bahawalpur, Pakistan
Author_xml	– sequence: 1 givenname: Qura Tul orcidid: 0000-0002-3651-2337 surname: Ain fullname: Ain, Qura Tul – sequence: 2 givenname: Samina Hyder surname: Haq fullname: Haq, Samina Hyder – sequence: 3 givenname: Abeer surname: Alshammari fullname: Alshammari, Abeer – sequence: 4 givenname: Moudhi Abdullah surname: Al-Mutlaq fullname: Al-Mutlaq, Moudhi Abdullah – sequence: 5 givenname: Muhammad Naeem surname: Anjum fullname: Anjum, Muhammad Naeem
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31165017$$D View this record in MEDLINE/PubMed
BookMark	eNptkstP3DAQh62KqlDKrecqUi89NNSv-HGpVCG6ICHRSnu3HD_Aq8SmdrIq_32dXYoA4ct47G9-nvHMe3AQU3QAfETwlHCGv_WbqGM6ra5Eb8ARRhK2FAt28GR_CE5K2cC6KMRCinfgkCDEOoj4Efi9vnVNuS-TG4NpnPfOTE3yza_zVRtX122IdjbONulvsHoK2wpP2ZXShNhswzYtVjc5WRenZqxm-ADeej0Ud_Jgj8H65_n67KK9ul5dnv24ag3lYmqxF1b31lrNhTAMod5SLRjbpcCg1Q5B4QT3rOOeaCmF4MJIZzRHjAlyDC73sjbpjbrLYdT5XiUd1O4g5Rul8xTM4BTRTHrMOekIoh2CfQ-JNcxwKSyyQlat73utu7kfnTW1lqyHZ6LPb2K4VTdpq1hHEaG4Cnx5EMjpz-zKpMZQjBsGHV2ai8KEQkg6vHvr8wt0k-Yc608pjKlkBMJuqe7T04weU_nfuAp83QMmp1Ky848IgmoZDbUfjcWVqOL4BW7CVPuZlnrC8HrQP8ONvTI
CitedBy_id	crossref_primary_10_1016_j_envpol_2021_116907 crossref_primary_10_1007_s10008_024_06079_y crossref_primary_10_3390_catal13040785 crossref_primary_10_1002_nano_70051 crossref_primary_10_1002_slct_202302938 crossref_primary_10_3390_nano12193443 crossref_primary_10_1016_j_arabjc_2023_105099 crossref_primary_10_1016_j_ceramint_2022_08_156 crossref_primary_10_1016_j_surfin_2023_103408 crossref_primary_10_1038_s41598_023_38993_y crossref_primary_10_1021_acsaelm_5c00349 crossref_primary_10_1016_j_ceramint_2022_09_070 crossref_primary_10_1080_25740881_2024_2369679 crossref_primary_10_1002_adem_202500949 crossref_primary_10_1007_s10562_025_05158_7 crossref_primary_10_2147_IJN_S271159 crossref_primary_10_1007_s11244_024_02022_7 crossref_primary_10_1002_ente_202200636 crossref_primary_10_1016_j_jobe_2023_106945 crossref_primary_10_1007_s13369_024_08905_x crossref_primary_10_1016_j_diamond_2024_111784 crossref_primary_10_1080_1536383X_2025_2530136 crossref_primary_10_1038_s41598_023_39498_4 crossref_primary_10_1016_j_triboint_2025_110554 crossref_primary_10_1007_s10971_025_06890_7 crossref_primary_10_3390_bios12030174 crossref_primary_10_2174_0115734137289697240216070503 crossref_primary_10_1007_s00339_023_06904_7 crossref_primary_10_1016_j_jobe_2025_112570 crossref_primary_10_3389_fmats_2023_1277467 crossref_primary_10_1016_j_jcis_2025_137549 crossref_primary_10_1002_ente_202100452 crossref_primary_10_1002_cssc_202201418 crossref_primary_10_1186_s12882_025_04087_2 crossref_primary_10_3390_polym14081606 crossref_primary_10_1002_smll_202204158 crossref_primary_10_1016_j_cherd_2023_05_029 crossref_primary_10_1016_j_jtice_2025_106245 crossref_primary_10_1038_s41598_023_27432_7 crossref_primary_10_3390_coatings13091558 crossref_primary_10_1002_adfm_202513744 crossref_primary_10_3390_polym12081840 crossref_primary_10_1016_j_jiec_2024_12_014 crossref_primary_10_3390_sym12060961 crossref_primary_10_1002_slct_202201056 crossref_primary_10_1016_j_plaphy_2021_09_010 crossref_primary_10_1002_adfm_202307723 crossref_primary_10_1039_D4NR03476G crossref_primary_10_1039_D3RA07186C crossref_primary_10_1016_j_apsusc_2022_152568 crossref_primary_10_1016_j_jenvman_2025_127020 crossref_primary_10_1016_j_electacta_2024_145235 crossref_primary_10_1016_j_heliyon_2023_e20665 crossref_primary_10_3390_w15020293 crossref_primary_10_1016_j_aca_2024_342234 crossref_primary_10_1016_j_materresbull_2021_111551 crossref_primary_10_1007_s13204_021_02243_2 crossref_primary_10_1016_j_rineng_2025_106737 crossref_primary_10_1016_j_ceramint_2025_08_222 crossref_primary_10_3390_molecules30071474 crossref_primary_10_1016_j_est_2023_109312 crossref_primary_10_3390_nano13081315 crossref_primary_10_1002_cctc_202500084 crossref_primary_10_1002_cphc_202400355 crossref_primary_10_1016_j_microc_2024_112231 crossref_primary_10_1039_D5SE00202H crossref_primary_10_3390_nano13172389 crossref_primary_10_1007_s12010_023_04736_y crossref_primary_10_1016_j_jksus_2022_102002 crossref_primary_10_1002_app_54097 crossref_primary_10_1016_j_matchemphys_2023_127995 crossref_primary_10_1016_j_surfin_2025_107524 crossref_primary_10_13005_ojc_380308 crossref_primary_10_3390_w14213413 crossref_primary_10_1016_j_matchemphys_2022_126786 crossref_primary_10_1016_j_electacta_2025_146677 crossref_primary_10_3390_ma14081916 crossref_primary_10_1007_s00289_022_04460_3 crossref_primary_10_1007_s10853_023_08700_3 crossref_primary_10_1016_j_est_2024_115068 crossref_primary_10_1002_slct_202500200 crossref_primary_10_1016_j_ijbiomac_2023_123724 crossref_primary_10_1021_acssusresmgt_5c00106 crossref_primary_10_1016_j_jallcom_2024_178137 crossref_primary_10_1007_s10854_023_10871_3 crossref_primary_10_1007_s00289_024_05262_5 crossref_primary_10_26599_NBE_2024_9290059 crossref_primary_10_1007_s42247_024_00904_w crossref_primary_10_1002_app_57098 crossref_primary_10_1016_j_ab_2023_115334 crossref_primary_10_1016_j_carbon_2024_119218 crossref_primary_10_1016_j_cdc_2023_101075 crossref_primary_10_1016_j_cscee_2024_100658 crossref_primary_10_1016_j_mseb_2025_118227 crossref_primary_10_1002_slct_202203272 crossref_primary_10_1016_j_seppur_2025_135036 crossref_primary_10_3390_nano13121850 crossref_primary_10_1016_j_jiec_2024_09_054 crossref_primary_10_1002_smll_202500329 crossref_primary_10_1002_aesr_202000064 crossref_primary_10_1007_s10163_023_01591_1 crossref_primary_10_1007_s11356_022_22389_y crossref_primary_10_1016_j_cdc_2022_100887 crossref_primary_10_1016_j_est_2024_112641 crossref_primary_10_1016_j_molstruc_2024_139810 crossref_primary_10_1088_1757_899X_1300_1_012014 crossref_primary_10_1002_pat_70300 crossref_primary_10_1177_09544089241255943 crossref_primary_10_1016_j_conbuildmat_2025_140600 crossref_primary_10_1038_s41598_022_12200_w crossref_primary_10_26599_NR_2025_94907258 crossref_primary_10_1016_j_fuel_2021_122807 crossref_primary_10_1016_j_synthmet_2023_117486 crossref_primary_10_1088_2053_1591_adc6ee crossref_primary_10_3390_nano13040734 crossref_primary_10_1007_s11237_025_09823_1 crossref_primary_10_1016_j_jwpe_2022_103289 crossref_primary_10_1016_j_diamond_2024_111292 crossref_primary_10_1002_advs_202405273 crossref_primary_10_1007_s10854_025_14936_3 crossref_primary_10_3390_nano11102523 crossref_primary_10_1007_s00339_022_05953_8 crossref_primary_10_1016_j_mtcomm_2024_109927 crossref_primary_10_1080_17435390_2021_2018734 crossref_primary_10_1038_s41598_024_71559_0 crossref_primary_10_1039_D3CY00308F crossref_primary_10_1080_1061186X_2021_1887200 crossref_primary_10_1039_D2SE00666A crossref_primary_10_1016_j_envres_2021_112510 crossref_primary_10_3390_membranes12070717 crossref_primary_10_1007_s11244_023_01879_4 crossref_primary_10_1088_1361_6528_aceaff crossref_primary_10_1134_S106377452460251X crossref_primary_10_1080_00319104_2020_1858418 crossref_primary_10_1016_j_microc_2025_113550 crossref_primary_10_1088_2043_6262_ac5498 crossref_primary_10_3390_nano11123278 crossref_primary_10_1016_j_elecom_2024_107703 crossref_primary_10_1007_s12008_022_01020_x crossref_primary_10_1016_j_molstruc_2024_140090 crossref_primary_10_1021_acsaem_5c01421 crossref_primary_10_1016_j_electacta_2025_146424 crossref_primary_10_1016_j_radphyschem_2023_110926 crossref_primary_10_1016_j_mtcomm_2023_106920 crossref_primary_10_21597_jist_1487166 crossref_primary_10_1007_s10856_024_06795_x crossref_primary_10_1016_j_envpol_2021_117054 crossref_primary_10_1016_j_est_2024_115016 crossref_primary_10_1016_j_jclepro_2025_144680 crossref_primary_10_3390_molecules27248728 crossref_primary_10_1016_j_microc_2025_113545 crossref_primary_10_1007_s11356_025_36517_x crossref_primary_10_1016_j_diamond_2023_110602 crossref_primary_10_1016_j_fuel_2020_118235 crossref_primary_10_1016_j_optmat_2021_111849 crossref_primary_10_1016_j_scitotenv_2022_157815 crossref_primary_10_1021_acsanm_5c02267
Cites_doi	10.1016/j.cbpc.2008.02.003 10.1016/j.actbio.2013.08.016 10.1002/smll.200901680 10.1016/j.cub.2014.03.034 10.1039/c4tb01760a 10.1016/s0076-6879(84)05016-3 10.3390/ijms19113564 10.1016/0304-4165(79)90289-7 10.1016/j.snb.2014.07.077 10.1007/s12274-012-0200-y 10.1021/am3019367 10.1016/j.mssp.2019.02.032 10.1016/j.snb.2014.12.098 10.1146/annurev.pa.36.040196.000503 10.3233/bme-141037 10.1097/wox.0b013e3182439613 10.1038/srep42767 10.1093/oxfordjournals.bmb.a072970 10.1021/nn1006368 10.1088/0957-4484/23/46/465103 10.1002/app.34901 10.1021/nn202451x 10.1039/c7tx00278e 10.1021/am404292e 10.1002/smll.201202538 10.1021/ie202132m 10.1039/c2cs35342c 10.1016/j.tca.2011.10.006 10.1016/j.carbon.2011.12.035 10.1021/ja803688x 10.1016/j.pathophys.2006.05.002 10.3390/nano8110944 10.1126/science.1063273 10.1021/nn101390x 10.1093/oxfordjournals.bmb.a072627 10.1016/j.biomaterials.2011.07.071 10.1002/9780470122778.ch5 10.1002/adma.200903783 10.1021/nn201560b 10.1016/j.carbon.2012.09.031 10.1166/jnn.2019.16531 10.1016/j.biomaterials.2013.01.010 10.1021/acs.jpcb.5b10330 10.1080/03602559.2012.751410 10.1016/j.jhazmat.2011.11.076 10.2174/1389450043345407 10.1016/j.jphotobiol.2014.05.023 10.1002/smll.201001522 10.1007/978-1-62703-475-3_13 10.1016/j.bios.2016.03.039 10.1063/1.3607305 10.2147/ijn.s148211 10.1021/nn1024303 10.2147/ijn.s66591
ContentType	Journal Article
Copyright	Copyright © 2019, Ain et al.; licensee Beilstein-Institut. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2019, Ain et al. 2019 Ain et al.
Copyright_xml	– notice: Copyright © 2019, Ain et al.; licensee Beilstein-Institut. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2019, Ain et al. 2019 Ain et al.
DBID	AAYXX CITATION NPM 3V. 7XB 88I 8FE 8FG 8FK ABUWG AFKRA ARAPS AZQEC BENPR BFMQW BGLVJ CCPQU DWQXO GNUQQ HCIFZ M2P P5Z P62 PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA
DOI	10.3762/bjnano.10.91
DatabaseName	CrossRef PubMed ProQuest Central (Corporate) ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Technology Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials ProQuest Central Continental Europe Database Technology Collection ProQuest One ProQuest Central ProQuest Central Student SciTech Premium Collection Science Database ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals
DatabaseTitle	CrossRef PubMed Publicly Available Content Database ProQuest Central Student Technology Collection ProQuest One Academic Middle East (New) ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Central Korea ProQuest Central (New) Advanced Technologies & Aerospace Collection ProQuest Science Journals (Alumni Edition) ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Technology Collection Continental Europe Database ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Publicly Available Content Database PubMed CrossRef
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Engineering
EISSN	2190-4286
EndPage	911
ExternalDocumentID	oai_doaj_org_article_3a69f27735314510bb03dc6c798d1d89 PMC6541342 31165017 10_3762_bjnano_10_91
Genre	Journal Article
GeographicLocations	Saudi Arabia
GeographicLocations_xml	– name: Saudi Arabia
GroupedDBID	53G 5VS 88I 8FE 8FG AAFWJ AAKDD AAYXX ABUWG ACGFO ACGOD ADBBV ADDVE ADRAZ AENEX AFFHD AFKRA AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS ARAPS AZQEC BAWUL BCNDV BENPR BFMQW BGLVJ BPHCQ CCPQU CITATION DIK DWQXO FRP GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HYE KQ8 M2P M48 M~E OK1 P62 PGMZT PHGZM PHGZT PIMPY PQGLB PQQKQ PROAC RNS RPM ~9O IPNFZ NPM RIG 3V. 7XB 8FK PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c478t-2f8dabddda788c611bd4a866effec60dae108e87f657f3a998878c9eca716683
IEDL.DBID	DOA
ISICitedReferencesCount	208
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000465334000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2190-4286
IngestDate	Mon Nov 10 04:34:24 EST 2025 Tue Nov 04 02:00:40 EST 2025 Fri Sep 05 14:22:44 EDT 2025 Sun Nov 09 06:56:08 EST 2025 Mon Jul 21 06:01:43 EDT 2025 Sat Nov 29 03:42:03 EST 2025 Tue Nov 18 21:33:46 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	nano-graphene oxide nanomedicine PEGylation oxidative stress
Language	English
License	http://creativecommons.org/licenses/by/4.0 This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms)
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c478t-2f8dabddda788c611bd4a866effec60dae108e87f657f3a998878c9eca716683
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0002-3651-2337
OpenAccessLink	https://doaj.org/article/3a69f27735314510bb03dc6c798d1d89
PMID	31165017
PQID	2249630058
PQPubID	2045589
PageCount	11
ParticipantIDs	doaj_primary_oai_doaj_org_article_3a69f27735314510bb03dc6c798d1d89 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6541342 proquest_miscellaneous_2340035289 proquest_journals_2249630058 pubmed_primary_31165017 crossref_primary_10_3762_bjnano_10_91 crossref_citationtrail_10_3762_bjnano_10_91
PublicationCentury	2000
PublicationDate	2019-00-00
PublicationDateYYYYMMDD	2019-01-01
PublicationDate_xml	– year: 2019 text: 2019-00-00
PublicationDecade	2010
PublicationPlace	Germany
PublicationPlace_xml	– name: Germany – name: Frankfurt am Main – name: Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany
PublicationTitle	Beilstein journal of nanotechnology
PublicationTitleAlternate	Beilstein J Nanotechnol
PublicationYear	2019
Publisher	Beilstein-Institut zur Föerderung der Chemischen Wissenschaften Beilstein-Institut
Publisher_xml	– name: Beilstein-Institut zur Föerderung der Chemischen Wissenschaften – name: Beilstein-Institut
References	ref13 ref57 ref12 ref56 ref15 ref14 ref53 ref11 ref10 ref54 ref17 ref16 ref19 ref18 Kakkar (ref55) 1984; 21 ref51 ref50 Visconti (ref38) 2009; 12 ref46 ref45 ref48 ref47 ref42 ref41 ref44 ref43 ref49 ref8 ref7 ref9 ref4 ref3 ref6 ref5 ref40 ref35 ref34 ref37 ref36 ref31 ref30 ref33 ref32 ref2 ref1 ref39 ref24 ref23 ref26 ref25 ref20 ref22 ref21 ref28 ref27 ref29
References_xml	– ident: ref53 doi: 10.1016/j.cbpc.2008.02.003 – ident: ref10 doi: 10.1016/j.actbio.2013.08.016 – ident: ref11 doi: 10.1002/smll.200901680 – ident: ref40 doi: 10.1016/j.cub.2014.03.034 – ident: ref44 doi: 10.1039/c4tb01760a – ident: ref54 doi: 10.1016/s0076-6879(84)05016-3 – ident: ref46 doi: 10.3390/ijms19113564 – ident: ref56 doi: 10.1016/0304-4165(79)90289-7 – ident: ref20 doi: 10.1016/j.snb.2014.07.077 – ident: ref12 doi: 10.1007/s12274-012-0200-y – ident: ref26 doi: 10.1021/am3019367 – ident: ref45 doi: 10.1016/j.mssp.2019.02.032 – ident: ref19 doi: 10.1016/j.snb.2014.12.098 – ident: ref39 doi: 10.1146/annurev.pa.36.040196.000503 – ident: ref15 doi: 10.3233/bme-141037 – ident: ref41 doi: 10.1097/wox.0b013e3182439613 – ident: ref51 doi: 10.1038/srep42767 – ident: ref37 doi: 10.1093/oxfordjournals.bmb.a072970 – ident: ref3 doi: 10.1021/nn1006368 – ident: ref32 doi: 10.1088/0957-4484/23/46/465103 – ident: ref4 doi: 10.1002/app.34901 – ident: ref17 doi: 10.1021/nn202451x – ident: ref34 doi: 10.1039/c7tx00278e – ident: ref43 doi: 10.1021/am404292e – ident: ref23 doi: 10.1002/smll.201202538 – ident: ref6 doi: 10.1021/ie202132m – ident: ref27 doi: 10.1039/c2cs35342c – ident: ref8 doi: 10.1016/j.tca.2011.10.006 – ident: ref13 doi: 10.1016/j.carbon.2011.12.035 – ident: ref33 doi: 10.1021/ja803688x – ident: ref36 doi: 10.1016/j.pathophys.2006.05.002 – ident: ref48 doi: 10.3390/nano8110944 – ident: ref1 doi: 10.1126/science.1063273 – ident: ref14 doi: 10.1021/nn101390x – volume: 12 start-page: 240 year: 2009 ident: ref38 publication-title: Current Opinion in Drug Discovery & Development – ident: ref35 doi: 10.1093/oxfordjournals.bmb.a072627 – ident: ref29 doi: 10.1016/j.biomaterials.2011.07.071 – ident: ref57 doi: 10.1002/9780470122778.ch5 – ident: ref22 doi: 10.1002/adma.200903783 – ident: ref25 doi: 10.1021/nn201560b – ident: ref9 doi: 10.1016/j.carbon.2012.09.031 – ident: ref47 doi: 10.1166/jnn.2019.16531 – ident: ref30 doi: 10.1016/j.biomaterials.2013.01.010 – volume: 21 start-page: 130 year: 1984 ident: ref55 publication-title: Indian Journal of Biochemistry & Biophysics – ident: ref50 doi: 10.1021/acs.jpcb.5b10330 – ident: ref7 doi: 10.1080/03602559.2012.751410 – ident: ref21 doi: 10.1016/j.jhazmat.2011.11.076 – ident: ref2 doi: 10.2174/1389450043345407 – ident: ref24 doi: 10.1016/j.jphotobiol.2014.05.023 – ident: ref16 doi: 10.1002/smll.201001522 – ident: ref49 doi: 10.1007/978-1-62703-475-3_13 – ident: ref18 doi: 10.1016/j.bios.2016.03.039 – ident: ref42 doi: 10.1063/1.3607305 – ident: ref31 doi: 10.2147/ijn.s148211 – ident: ref5 doi: 10.1021/nn1024303 – ident: ref28 doi: 10.2147/ijn.s66591
SSID	ssj0000402898
Score	2.574037
Snippet	Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	901
SubjectTerms	Acids Antioxidants Brain Cancer therapies Catalase Chemotherapy Drug delivery systems Enzymes Fourier transforms Free radicals Full Research Paper Glutathione Graphene Graphite In vivo methods and tests Kidneys Lipids nano-graphene oxide nanomedicine Nanoscience Nanotechnology Organs Oxidation Oxidative stress PEGylation Peroxides Photon correlation spectroscopy Polyethylene glycol Scavenging Size distribution Spectrum analysis Superoxide dismutase Tissue engineering Transmission electron microscopy X-ray diffraction
SummonAdditionalLinks	– databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7BlgMcyrsECjISnJBpHDt-nFCLtuW0LKiH3iLHTiCocsrudsXP7zjJhm4FXDhFia1kknl4Zjz5BuCNYJk3Ns-oR-eVCukkNU6ktBLxf5Vala50XbMJNZvpszMzHxJuy6GscmMTO0PtWxdz5Ae41JgID5XrDxc_aewaFXdXhxYat2EnIpWJCewcTWfzr2OWBUUUIwrdV7yjLmUH5Y9gQ4tB63vDttaiDrL_T37mzXLJa-vP8f3_pfwB7A6eJznsReUh3KrCI7h3DY_wMXxBoSE9tnPjSF_qQdqazKcnNJx8phi_oyR40v5qfAcYTvpfTUgTyLpZt_FoCZpkfAXS9dh5AqfH09OPn-jQc4E6ofSKZrX2tvTeW4yNnWSs9MJqKbtHytTbiqW60qqWuaq5xWBNK-1M5SwGXlLzpzAJbaieAeE45JVlGatTUXttU16yXHHpcnQZrUjg3ebjF27AI49tMc4LjEsiq4qeVfHUsATejrMvehyOv8w7inwc50T07O5Cu_hWDMpYcCtNnSnF0QAJNEplmXLvpFNGe-a1SWB_w8liUOll8ZuNCbweh1EZ4w6LDVV7iXO46ABm4y32eqEZKeER6AjtXwJqS5y2SN0eCc33DvA79mrnInv-b7JewF305kyfH9qHyWpxWb2EO269apaLV4NmXAGW-BrO priority: 102 providerName: ProQuest
Title	The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model
URI	https://www.ncbi.nlm.nih.gov/pubmed/31165017 https://www.proquest.com/docview/2249630058 https://www.proquest.com/docview/2340035289 https://pubmed.ncbi.nlm.nih.gov/PMC6541342 https://doaj.org/article/3a69f27735314510bb03dc6c798d1d89
Volume	10
WOSCitedRecordID	wos000465334000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2190-4286 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402898 issn: 2190-4286 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources (selected full-text only) customDbUrl: eissn: 2190-4286 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402898 issn: 2190-4286 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 2190-4286 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402898 issn: 2190-4286 databaseCode: P5Z dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Continental Europe Database customDbUrl: eissn: 2190-4286 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402898 issn: 2190-4286 databaseCode: BFMQW dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/conteurope providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2190-4286 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402898 issn: 2190-4286 databaseCode: BENPR dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2190-4286 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402898 issn: 2190-4286 databaseCode: PIMPY dateStart: 20150101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 2190-4286 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402898 issn: 2190-4286 databaseCode: M2P dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5B4QCHimdJKSsjwQmFxrHjx5Gi3cJhlxRVYuESOXYiglCC2u2Kn8_YTle7CMSFi61krMSZGdsz8fgbgBec5k6bIk8dGq8pF1ak2vIsbbg_r9LK2tY2JJuQi4VaLnW5lerLx4RFeODIuGNmhG5zKRkqC0cFquuMOSus1MpRp8LRPbR6tpypMAdzv4MW0tH5s9JoY4sY9Y7jKT-uv_WmH9Bxfa3pznoUYPv_ZGv-HjK5tQbN7sH-aDySN7HT9-FG0z-Au1uQgg_hDOVOIjxzZ0mM1iBDS8rpadqffkjRBUdhOjL87FzA_CbxtAjperLu1oOvDcFZFXtAQpqcR3A-m56_fZeOaRNSy6VapXmrnKmdcwbdWysorR03SojwSpE509BMNUq2opAtM-hvKamsbqxB30ko9hj2-qFvngBhSHLS0Jy2GW-dMhmraSGZsAVafYYn8Oqad5UdIcV9ZovvFboWntNV5LS_1DSBl5vWPyKUxl_anXgxbNp4AOxwA9WiGtWi-pdaJHB0LcRqHJWXFZor2kOMFSqB5xsyjie_SWL6ZrjCNowHjFj_iIMo801PmMcqwiksAbmjDTtd3aX03deA2e3TrTOeH_6Pb3sKd9Bs0_FH0BHsrS6ummdw265X3eXFBG7KpZrArZPpovzo69n87NMkDA8s53mJZVl8QUr5fl5-_gUQFhQT
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VFoly4P0IFDAS5YJC49jx48CBQret2i6ttFJ7ixw7KUEoKbvbBX4U_5Fxkg1dBNx64BQltizH_mY8Y4-_AXjBaey0SeLQofEacmFFqC2Pwpz7-yqFzGxmm2QTcjhUJyf6cAl-zO_C-LDKuU5sFLWrrd8j38ClRnt6qER1EZR7-fev6J9N3uy-x8lcj-PB1ujdTtilEAgtl2oaxoVyJnPOGXT1rKA0c9woIZpgCRE5k9NI5UoWIpEFM-h7KKmszq1BP0Iohs2-PPsS-iRV_jC3y9hxBVaU0AzFamVzcHB03G_qoESgA6PaAHsU3Xgj-1SZqkYf-bWmC0tfkyHgT2bt79GZF5a7wc3_bKBuwY3OriZvW0G4DUt5dQeuX2BbvAtHKBKkZa4uLWkDWUhdkMOt7bDa_hCWlUOcO1J_K11Dh07aizSkrMisnNX-aQguODhipMkgdA9Gl_GX92G5qqv8IRCGRU4aGtMi4oVTJmIZTSQTNkGD2PAAXs3nOrUd27pP-vE5Ra_LIyNtkeFfNQ1gva991rKM_KXepodNX8dzgzcf6vFp2qmalBmhi1hKhuqVo8rNsog5K6zUylGndABrc-CkncKapL9QE8DzvhhVjT8_MlVen2Mdxhv6XN_EgxajfU-Yp3FC7R6AXEDvQlcXS6ryY0Nn7jPRMx4_-ne3nsG1ndHBfrq_O9x7DKtot-p2J2wNlqfj8_wJXLWzaTkZP-2EkkB6yYD_CUIDeb8
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VghAceD8CBYxET8hsEjt-HBAC2i1V0bJIPVS9RI6dtEEoKbvbBX4a_45xXnQRcOuBU5TYshz7m_GMPf4G4BmPYqdNElOHxivlwgqqLQ9pzv19lUJmNrNNsgk5maiDAz1dgx_9XRgfVtnrxEZRu9r6PfIRLjXa00MlalR0YRHTrfGrky_UZ5DyJ619Oo0WInv596_ovs1f7m7hXG_G8Xh7_-072mUYoJZLtaBxoZzJnHMGPUEroihz3CghmlgKETqTR6HKlSxEIgtm0DVRUlmdW4NuhlAMm70AFyW6mF64psnhsL2DsoGujGpD7VGI41H2qTJVjd7yCx2tLIJNroA_Gbi_x2meWfjG1__jIbsB1zprm7xuxeMmrOXVLbh6hoPxNnxEQSEtn3VpSRveQuqCTLd3aLXzgZaVQ_Q7Un8rXUOSTtrrNaSsyLJc1v5pCC5DOHqkySt0B_bP45fuwnpVV_l9IAyLnDRRHBUhL5wyIcuiRDJhEzSTDQ_geT_vqe042H0qkM8p-mIeJWmLEv-qowA2h9onLffIX-q98RAa6njG8OZDPTtKOwWUMiN0EUvJUOlyVMRZFjJnhZVaucgpHcBGD6K0U2Pz9BeCAng6FKMC8qdKpsrrU6zDeEOq65u41-J16Anz5E6o8wOQK0he6epqSVUeNyTnPj894_GDf3frCVxGSKfvdyd7D-EKGrO63R7bgPXF7DR_BJfsclHOZ48b6SSQnjO0fwJL0oFA
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+systemic+effect+of+PEG-nGO-induced+oxidative+stress+in+vivo+in+a+rodent+model&rft.jtitle=Beilstein+journal+of+nanotechnology&rft.au=Ain%2C+Qura+Tul&rft.au=Haq%2C+Samina+Hyder&rft.au=Alshammari%2C+Abeer&rft.au=Al-Mutlaq%2C+Moudhi+Abdullah&rft.date=2019&rft.issn=2190-4286&rft.eissn=2190-4286&rft.volume=10&rft.spage=901&rft_id=info:doi/10.3762%2Fbjnano.10.91&rft_id=info%3Apmid%2F31165017&rft.externalDocID=31165017
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2190-4286&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2190-4286&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2190-4286&client=summon