The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer

When originally discovered, one of the initial observations was that, when all of the insulin peptide was depleted from serum, the vast majority of the insulin activity remained and this was due to a single additional peptide, IGF-II. The IGF-II gene is adjacent to the insulin gene, which is a resul...

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Veröffentlicht in:Cells (Basel, Switzerland) Jg. 8; H. 10; S. 1207
Hauptverfasser: Holly, Jeff M. P., Biernacka, Kalina, Perks, Claire M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 06.10.2019
MDPI
Schlagworte:
Alternative splicing
Amino acids
Antisense RNA
cancer
Chromosomes
Diabetes
Diabetes mellitus
Gene duplication
Gene loci
Hypoglycemia
igf-ii
Insulin
Insulin-like growth factor II
Insulin-like growth factors
Metabolic disorders
Metabolism
mRNA
Non-coding RNA
obesity
Peptides
Physiology
Review
Tumors
cancer
metabolism
insulin
diabetes
obesity
IGF-II
ISSN:2073-4409, 2073-4409
Online-Zugang:Volltext
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Zusammenfassung:When originally discovered, one of the initial observations was that, when all of the insulin peptide was depleted from serum, the vast majority of the insulin activity remained and this was due to a single additional peptide, IGF-II. The IGF-II gene is adjacent to the insulin gene, which is a result of gene duplication, but has evolved to be considerably more complicated. It was one of the first genes recognised to be imprinted and expressed in a parent-of-origin specific manner. The gene codes for IGF-II mRNA, but, in addition, also codes for antisense RNA, long non-coding RNA, and several micro RNA. Recent evidence suggests that each of these have important independent roles in metabolic regulation. It has also become clear that an alternatively spliced form of the insulin receptor may be the principle IGF-II receptor. These recent discoveries have important implications for metabolic disorders and also for cancer, for which there is renewed acknowledgement of the importance of metabolic reprogramming.
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ISSN:2073-4409
2073-4409
DOI:10.3390/cells8101207