The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer

When originally discovered, one of the initial observations was that, when all of the insulin peptide was depleted from serum, the vast majority of the insulin activity remained and this was due to a single additional peptide, IGF-II. The IGF-II gene is adjacent to the insulin gene, which is a resul...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 8; no. 10; p. 1207
Main Authors:	Holly, Jeff M. P., Biernacka, Kalina, Perks, Claire M.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 06.10.2019 MDPI
Subjects:	Alternative splicing Amino acids Antisense RNA cancer Chromosomes Diabetes Diabetes mellitus Gene duplication Gene loci Hypoglycemia igf-ii Insulin Insulin-like growth factor II Insulin-like growth factors Metabolic disorders Metabolism mRNA Non-coding RNA obesity Peptides Physiology Review Tumors cancer metabolism insulin diabetes obesity IGF-II
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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