Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes

Background/Aim Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta‐cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody‐positive individuals increases...

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Vydáno v:Diabetes/metabolism research and reviews Ročník 40; číslo 2; s. e3777 - n/a
Hlavní autoři: Hendriks, A. Emile J., Marcovecchio, M. Loredana, Besser, Rachel E. J., Bonifacio, Ezio, Casteels, Kristina, Elding Larsson, Helena, Gemulla, Gita, Lundgren, Markus, Kordonouri, Olga, Mallone, Roberto, Pociot, Flemming, Szypowska, Agnieszka, Toppari, Jorma, Ziegler, Anette G., Mathieu, Chantal, Achenbach, Peter, Mathieu, C., Gillard, P., Casteels, K., Overbergh, L., Wallace, C., Evans, M., Thankamony, A., Hendriks, A. E. J., Bruggraber, S., Marcovecchio, M. L., Peakman, M., Tree, T., Richardson, S., Todd, J., Wicker, L., Mander, A., Dayan, C., Alhadj Ali, M., Pieber, T., Eizirik, D., Cnop, M., Brunak, S., Pociot, F., Johannesen, J., Rossing, P., Legido Quigley, C., Mallone, R., Scharfmann, R., Boitard, C., Knip, M., Otonkoski, T., Lahesmaa, R., Oresic, M., Toppari, J., Danne, T., Ziegler, A. G., Achenbach, P., Rodriguez‐Calvo, T., Solimena, M., Bonifacio, E., Speier, S., Holl, R., Dotta, F., Chiarelli, F., Marchetti, P., Bosi, E., Cianfarani, S., Ciampalini, P., Beaufort, C., Dahl‐Jørgensen, K., Skrivarhaug, T., Krogvold, L., Jarosz‐Chobot, P., Battelino, T., Thorens, B., Roep, B., Nikolic, T., Zaldumbide, A., Lernmark, A., Costecalde, G., Strube, T., Schulte, A., Nitsche, A., Vela, J., Herrath, M., Wesley, J., Napolitano‐Rosen, A., Thomas, M., Schloot, N., Goldfine, A., Waldron‐Lynch, F., Kompa, J., Vedala, A., Hartmann, N., Nicolas, G., Rampelbergh, J., Bovy, N., Dutta, S., Soderberg, J., Ahmed, S., Martin, F., Latres, E., Koralova, A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.02.2024
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ISSN:1520-7552, 1520-7560, 1520-7560
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Abstract Background/Aim Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta‐cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody‐positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis. Methods Expert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow‐up strategies. Results The guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3‐monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented. Conclusions As type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.
AbstractList Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis. Expert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow-up strategies. The guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3-monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented. As type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.
Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis.BACKGROUND/AIMType 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis.Expert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow-up strategies.METHODSExpert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow-up strategies.The guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3-monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented.RESULTSThe guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3-monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented.As type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.CONCLUSIONSAs type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.
Background/AimType 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta‐cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody‐positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis.MethodsExpert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow‐up strategies.ResultsThe guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3‐monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented.ConclusionsAs type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.
Background/Aim: Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis. Methods: Expert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow-up strategies. Results: The guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3-monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented. Conclusions: As type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.
Background/Aim Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta‐cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody‐positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis. Methods Expert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow‐up strategies. Results The guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3‐monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented. Conclusions As type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings.
Author Elding Larsson, Helena
Costecalde, G.
Hendriks, A. E. J.
Szypowska, Agnieszka
Dayan, C.
Scharfmann, R.
Richardson, S.
Nikolic, T.
Solimena, M.
Lundgren, Markus
Goldfine, A.
Veijola, R.
Cnop, M.
Krogvold, L.
Rampelbergh, J.
Gillard, P.
Vela, J.
Latres, E.
Johannesen, J.
Strube, T.
Casteels, K.
Schulte, A.
Bruggraber, S.
Ziegler, Anette G.
Toppari, J.
Pieber, T.
Speier, S.
Hendriks, A. Emile J.
Herrath, M.
Beaufort, C.
Kordonouri, Olga
Skrivarhaug, T.
Dunger, D.
Wicker, L.
Legido Quigley, C.
Oresic, M.
Nitsche, A.
Peakman, M.
Joner, G.
Mallone, Roberto
Marchetti, P.
Thomas, M.
Ciampalini, P.
Gemulla, Gita
Bonifacio, E.
Alhadj Ali, M.
Overbergh, L.
Danne, T.
Boitard, C.
Besser, Rachel E. J.
Evans, M.
Waldron‐Lynch, F.
Bonifacio, Ezio
Todd, J.
Ahmed, S.
Pociot, F.
Nicolas, G.
Lahesmaa, R.
Wesley, J.
Agiostratidou, G.
Marcovecchio, M. L.
Holl, R.
Pociot, Flemming
Knip, M.
Casteels, Kristina
Berge, Thekla von dem
Otonkoski, T.
Ziegler, A. G.
Vedala, A.
Mathieu, C.
Thankamony, A.
Chiarelli, F.
Dahl‐Jørgensen, K.
Brunak, S.
Battelino, T.
Wallace, C.
Cianfarani, S.
Topp
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38375753$$D View this record in MEDLINE/PubMed
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Copyright 2024 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.
2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2024 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.
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CorporateAuthor INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group
Lunds universitet
Profile areas and other strong research environments
Department of Clinical Sciences, Malmö
Lund University
Strategiska forskningsområden (SFO)
EXODIAB: Excellence of Diabetes Research in Sweden
Faculty of Medicine
Strategic research areas (SRA)
Medicinska fakulteten
Pediatrisk endokrinologi
Profilområden och andra starka forskningsmiljöer
Institutionen för kliniska vetenskaper, Malmö
Paediatric Endocrinology
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– name: Lunds universitet
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– name: Paediatric Endocrinology
– name: Lund University
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– name: Profile areas and other strong research environments
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Issue 2
Keywords presymptomatic type 1 diabetes
primary care
specialist care
screening
monitoring
staging
Language English
License Attribution
2024 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.
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References 2015; 58
2019; 9
2015; 38
1986; 314
2021; 44
2022; 71
2020; 63
2013; 309
2023; 19
2022; 23
2019; 104
2022; 45
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2012; 35
2012; 55
2019; 381
2021; 70
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2016; 5
2016; 6
2004; 53
2023; 46
2023; 66
2021; 11
2019; 20
2002; 45
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Snippet Background/Aim Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta‐cell antigens, preceding...
Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical...
Background/AimType 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta‐cell antigens, preceding...
Background/Aim: Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding...
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SubjectTerms Antigens
Autoantibodies
Autoimmune diseases
Clinical Medicine
Diabetes
Diabetes mellitus (insulin dependent)
Diagnosis
Endocrinology and Diabetes
Endokrinologi och diabetes
Glucose monitoring
Ketoacidosis
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
monitoring
presymptomatic type 1 diabetes
Primary care
screening
specialist care
staging
Title Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdmrr.3777
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