Clinical effectiveness and speed of response of electroconvulsive therapy in treatment‐resistant schizophrenia

Aim Although electroconvulsive therapy (ECT) has been shown to be efficacious for patients with treatment‐resistant schizophrenia, there has been limited evidence on the rate of response, cognition, and quality‐of‐life outcomes. The primary aims of the present study were thus to examine the effectiv...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry and clinical neurosciences Vol. 73; no. 7; pp. 416 - 422
Main Authors: Chan, Christopher Yi Wen, Abdin, Edimansyah, Seow, Esmond, Subramaniam, Mythily, Liu, Jianlin, Peh, Chao Xu, Tor, Phern Chern
Format: Journal Article
Language:English
Published: Melbourne John Wiley & Sons Australia, Ltd 01.07.2019
Wiley Subscription Services, Inc
Subjects:
Adult
cognition
Cognitive ability
Electroconvulsive Therapy
Female
Humans
Male
Mental disorders
Middle Aged
neurostimulation
Patients
Psychiatric Status Rating Scales
Psychosis
Quality of Life
Retrospective Studies
Schizophrenia
Schizophrenia - therapy
Time Factors
Treatment Outcome
Treatment resistance
treatment‐resistant schizophrenia
Young Adult
electroconvulsive therapy
treatment-resistant schizophrenia
cognition
quality of life
neurostimulation
ISSN:1323-1316, 1440-1819, 1440-1819
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim Although electroconvulsive therapy (ECT) has been shown to be efficacious for patients with treatment‐resistant schizophrenia, there has been limited evidence on the rate of response, cognition, and quality‐of‐life outcomes. The primary aims of the present study were thus to examine the effectiveness and speed of response to ECT in a naturalistic retrospective cohort in patients with treatment‐resistant schizophrenia. Methods We performed a retrospective database analysis. The primary effectiveness outcome was defined as an improvement of ≥40% from pretreatment scores based on the Brief Psychiatric Rating Scale (BPRS) Psychotic Symptom subscale. Data were included for analysis for all patients with a primary DSM‐5 diagnosis of schizophrenia that was treatment‐resistant and who had had an acute course of ECT initiated for the treatment of schizophrenia between 1 July 2016 and 1 December 2016. Results A total of 50 inpatients were included for analysis. The present study revealed that 50% of patients showed at least a 40% reduction in BPRS Psychotic Symptom subscale scores after completion of ECT and that 16.7% of patients responded after the first three sessions, 39.3% after six sessions, 46.4% after nine sessions, and 50% after 12 sessions. The greatest improvement in BPRS scores was between the third and sixth ECT sessions. BPRS scores, Clinical Global Impression, Montreal Cognitive Assessment, and Global Assessment of Functioning showed significant improvement. There was no significant difference in quality‐of‐life outcomes. Conclusion Utilizing modern techniques in treatment‐resistant schizophrenia, this study demonstrates the real‐world effectiveness and rate of response of patients receiving ECT.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1323-1316
1440-1819
1440-1819
DOI:10.1111/pcn.12855