Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model

Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the develop...

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Veröffentlicht in:	Annals of the New York Academy of Sciences Jg. 1397; H. 1; S. 130 - 142
Hauptverfasser:	Sturgeon, Craig, Lan, Jinggang, Fasano, Alessio
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.06.2017
Schlagworte:	Animals barrier function Body Weight - drug effects Cholera Toxin - antagonists & inhibitors Cholera Toxin - genetics Cholera Toxin - metabolism Colitis Colitis - chemically induced Colitis - genetics Colitis - physiopathology Dextran Dextran Sulfate Drinking water Duodenum Environmental monitoring Female Gene expression Histology Impairment inflammation Inflammatory bowel disease Inflammatory diseases Intestinal Mucosa - metabolism Intestinal Mucosa - physiopathology intestinal permeability Intestine Intestine, Small - metabolism Intestine, Small - physiopathology Jejunum Kaplan-Meier Estimate Male Mice Mice, Inbred C57BL Mice, Transgenic Morbidity Mortality Oligopeptides - pharmacology Pathogenesis Permeability Permeability - drug effects Rodents Sodium Sodium sulfate Sulfates Tight junctions Time Factors Transgenic mice Weight loss zonulin intestinal permeability zonulin tight junctions inflammation barrier function
ISSN:	0077-8923, 1749-6632, 1749-6632
Online-Zugang:	Volltext
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