Current findings and perspectives on aberrant neural oscillations in schizophrenia

There is now consistent evidence that neural oscillation at low‐ and high‐frequencies constitute an important aspect of the pathophysiology of schizophrenia. Specifically, impaired rhythmic activity may underlie the deficit to generate coherent cognition and behavior, leading to the characteristic s...

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Bibliographic Details
Published in:Psychiatry and clinical neurosciences Vol. 75; no. 12; pp. 358 - 368
Main Authors: Hirano, Yoji, Uhlhaas, Peter J.
Format: Journal Article
Language:English
Published: Melbourne John Wiley & Sons Australia, Ltd 01.12.2021
Wiley Subscription Services, Inc
Subjects:
Animal models
Animals
Cognition Disorders - complications
Cognition Disorders - physiopathology
Cognitive ability
EEG
Electroencephalography
Glutamatergic transmission
Humans
Interneurons
Magnetoencephalography
MEG
Mental disorders
neural oscillation
Neuroimaging
Neurotransmission
Oscillations
Psychosis
Rhythms
Schizophrenia
Schizophrenia - complications
Schizophrenia - physiopathology
Synaptic Transmission
γ-Aminobutyric acid
neural oscillation
schizophrenia
EEG
MEG
ISSN:1323-1316, 1440-1819, 1440-1819
Online Access:Get full text
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Summary:There is now consistent evidence that neural oscillation at low‐ and high‐frequencies constitute an important aspect of the pathophysiology of schizophrenia. Specifically, impaired rhythmic activity may underlie the deficit to generate coherent cognition and behavior, leading to the characteristic symptoms of psychosis and cognitive deficits. Importantly, the generating mechanisms of neural oscillations are relatively well‐understood and thus enable the targeted search for the underlying circuit impairments and novel treatment targets. In the following review, we will summarize and assess the evidence for aberrant rhythmic activity in schizophrenia through evaluating studies that have utilized Electro/Magnetoencephalography to examine neural oscillations during sensory and cognitive tasks as well as during resting‐state measurements. These data will be linked to current evidence from post‐mortem, neuroimaging, genetics, and animal models that have implicated deficits in GABAergic interneurons and glutamatergic neurotransmission in oscillatory deficits in schizophrenia. Finally, we will highlight methodological and analytical challenges as well as provide recommendations for future research.
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ISSN:1323-1316
1440-1819
1440-1819
DOI:10.1111/pcn.13300