Effect of the P-Selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial

COVID-19 has been associated with endothelial injury, resultant microvascular inflammation and thrombosis. Activated endothelial cells release and express P-selectin and von Willebrand factor, both of which are elevated in severe COVID-19 and may be implicated in the disease pathophysiology. We hypo...

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Vydáno v:	Circulation (New York, N.Y.) Ročník 148; číslo 5; s. 381
Hlavní autoři:	Solomon, Scott D, Lowenstein, Charles J, Bhatt, Ankeet S, Peikert, Alexander, Vardeny, Orly, Kosiborod, Mikhail N, Berger, Jeffrey S, Reynolds, Harmony R, Mavromichalis, Stephanie, Barytol, Anya, Althouse, Andrew D, Luther, James F, Leifer, Eric S, Kindzelski, Andrei L, Cushman, Mary, Gong, Michelle N, Kornblith, Lucy Z, Khatri, Pooja, Kim, Keri S, Baumann Kreuziger, Lisa, Wahid, Lana, Kirwan, Bridget-Anne, Geraci, Mark W, Neal, Matthew D, Hochman, Judith S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.08.2023
Témata:	COVID-19 Endothelial Cells Humans P-Selectin SARS-CoV-2 Treatment Outcome COVID-19 crizanlizumab P-selectin
ISSN:	1524-4539, 1524-4539
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