Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

Although patients with advanced ovarian cancer may respond initially to treatment, disease relapse is common, and nearly 50% of patients do not survive beyond five years, indicating an urgent need for improved therapies. To identify new therapeutic targets, we performed single-cell and nuclear RNA-s...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 81; H. 20; S. 5336
Hauptverfasser:	Geethadevi, Anjali, Nair, Ajay, Parashar, Deepak, Ku, Zhiqiang, Xiong, Wei, Deng, Hui, Li, Yongsheng, George, Jasmine, McAllister, Donna M, Sun, Yunguang, Kadamberi, Ishaque P, Gupta, Prachi, Dwinell, Michael B, Bradley, William H, Rader, Janet S, Rui, Hallgeir, Schwabe, Robert F, Zhang, Ningyan, Pradeep, Sunila, An, Zhiqiang, Chaluvally-Raghavan, Pradeep
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.10.2021
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer-Associated Fibroblasts - immunology Cell Proliferation Cytokine Receptor gp130 - genetics Cytokine Receptor gp130 - metabolism Female Gene Expression Regulation, Neoplastic - drug effects Humans Mice Mice, Nude Neoplasm Metastasis Oncostatin M - genetics Oncostatin M - metabolism Oncostatin M Receptor beta Subunit - antagonists & inhibitors Oncostatin M Receptor beta Subunit - immunology Oncostatin M Receptor beta Subunit - metabolism Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovarian Neoplasms - prevention & control Prognosis STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor Cells, Cultured Tumor Microenvironment Xenograft Model Antitumor Assays
ISSN:	1538-7445, 1538-7445
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