Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development

Secreted Dickkopf (Dkk) proteins are major Wnt pathway modulators during organ development. Dkk1 has been widely studied and acts as a general Wnt inhibitor. However, the molecular function of other Dkks remains largely unknown. Here, we show that Dkk4 selectively inhibits a subset of Wnts, but is f...

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Vydané v:	Development (Cambridge) Ročník 143; číslo 24; s. 4723
Hlavní autori:	Sima, Jian, Piao, Yulan, Chen, Yaohui, Schlessinger, David
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 15.12.2016
Predmet:	Animals Cell Line HEK293 Cells Humans Intercellular Signaling Peptides and Proteins - metabolism Low Density Lipoprotein Receptor-Related Protein-6 - metabolism Meibomian Glands - growth & development Mice Mice, Inbred C57BL Mice, Transgenic Protein Binding Skin - metabolism Wnt Proteins - antagonists & inhibitors Wnt Proteins - metabolism Wnt Signaling Pathway - physiology Dkk4 Eda Mouse Proteolytic cleavage Lrp6 Wnt Meibomian gland
ISSN:	1477-9129, 1477-9129
On-line prístup:	Zistit podrobnosti o prístupe
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