Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development

Secreted Dickkopf (Dkk) proteins are major Wnt pathway modulators during organ development. Dkk1 has been widely studied and acts as a general Wnt inhibitor. However, the molecular function of other Dkks remains largely unknown. Here, we show that Dkk4 selectively inhibits a subset of Wnts, but is f...

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Bibliographic Details
Published in:	Development (Cambridge) Vol. 143; no. 24; p. 4723
Main Authors:	Sima, Jian, Piao, Yulan, Chen, Yaohui, Schlessinger, David
Format:	Journal Article
Language:	English
Published:	England 15.12.2016
Subjects:	Animals Cell Line HEK293 Cells Humans Intercellular Signaling Peptides and Proteins - metabolism Low Density Lipoprotein Receptor-Related Protein-6 - metabolism Meibomian Glands - growth & development Mice Mice, Inbred C57BL Mice, Transgenic Protein Binding Skin - metabolism Wnt Proteins - antagonists & inhibitors Wnt Proteins - metabolism Wnt Signaling Pathway - physiology Dkk4 Eda Mouse Proteolytic cleavage Lrp6 Wnt Meibomian gland
ISSN:	1477-9129, 1477-9129
Online Access:	Get more information
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