Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens

Autoimmune encephalitis (AE) is an inflammatory syndrome of the central nervous system (CNS) triggered by aberrant immune responses against neuronal intracellular (IC-AE) or surface (NS-AE) autoantigens. The resulting neuronal alterations and clinical trajectories differ, with IC-AE often leading to...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 149; no. 1; p. 35
Main Authors:	Di Liberto, Giovanni, Egervari, Kristof, Vogrig, Alberto, Spatola, Marianna, Piccinno, Margot, Vincenti, Ilena, Wagner, Ingrid, Kreutzfeldt, Mario, Endmayr, Verena, Ostertag, Karoline, Rahimi, Jasmin, Vicino, Alex, Pröbstel, Anne-Katrin, Meyronet, David, Frank, Stephan, Prinz, Marco, Hewer, Ekkehard, Brouland, Jean-Philippe, de Leval, Laurence, Parkkinen, Laura, Draganski, Bogdan, Desestret, Virginie, Dubey, Divyanshu, Pittock, Sean J., Roemer, Shanu F., Dickson, Dennis W., Höftberger, Romana, Irani, Sarosh R., Honnorat, Jérôme, Du Pasquier, Renaud, Merkler, Doron
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 25.04.2025 Springer Nature B.V
Subjects:	Adult Aged Antibodies Antigens Autoantigens Autoantigens - immunology Autoimmune diseases Biomarkers Brain - immunology Brain - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Central nervous system Complement component C3 Disease Encephalitis Encephalitis - immunology Encephalitis - metabolism Encephalitis - pathology Female Females Genotype & phenotype Hashimoto Disease - immunology Hashimoto Disease - pathology Humans Immunological memory Intracellular Lymphocytes Lymphocytes T Male Males Medical prognosis Medicine Medicine & Public Health Memory Memory cells Middle Aged Nervous system Neurodegeneration Neurons - immunology Neurons - metabolism Neurons - pathology Neurosciences Original Paper Pathogenesis Pathology Phagocytes Proteins STAT1 Transcription Factor - metabolism Synapses - immunology Synapses - metabolism Synapses - pathology Young Adult Phagocytes Neuroinflammation Resident memory T cells Neurodegeneration Synapses
ISSN:	1432-0533, 0001-6322, 1432-0533
Online Access:	Get full text
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