The Progress and Pitfalls of Pharmacogenetics-Based Precision Medicine in Schizophrenia Spectrum Disorders: A Systematic Review and Meta-Analysis

The inadequate efficacy and adverse effects of antipsychotics severely affect the recovery of patients with schizophrenia spectrum disorders (SSD). We report the evidence for associations between pharmacogenetic (PGx) variants and antipsychotics outcomes, including antipsychotic response, antipsycho...

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Bibliographic Details
Published in:	Journal of personalized medicine Vol. 13; no. 3; p. 471
Main Authors:	Teng, Yuxin, Sandhu, Amrit, Liemburg, Edith J., Naderi, Elnaz, Alizadeh, Behrooz Z.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 04.03.2023 MDPI
Subjects:	Antipsychotic drugs Antipsychotics Brain-derived neurotrophic factor Clinical outcomes Clozapine Complications and side effects CYP2D6 protein Cytochrome P450 Decision making Development and progression Dopamine D1 receptors Dopamine D2 receptors Dopamine D3 receptors Dopamine receptors Drb1 protein Drug therapy Genetic aspects Information sources Mental disorders Meta-analysis Metabolic syndrome Metabolism Movement disorders Neutropenia Patient compliance Pharmacogenetics Pharmacokinetics Phenotypes Plasma levels Precision medicine Prolactin Psychiatry Psychotropic drugs Schizophrenia SNAP-25 protein Systematic Review Tardive dyskinesia Netherlands drug response weigh-gain personalized psychiatry antipsychotics pharmacokinetics CYP adverse events schizophrenia pharmacogenetics tardive dyskinesia
ISSN:	2075-4426, 2075-4426
Online Access:	Get full text
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