Association between mild or moderate obstructive sleep apnea-hypopnea syndrome and cognitive dysfunction in children
Childhood obstructive sleep apnea–hypopnea syndrome (OSAHS), the most common sleep-related breathing disorder, may lead to cognitive impairment. This study aims to investigate the association between mild or moderate childhood OSAHS and cognitive dysfunction. A total of 59 children (4–12 years of ag...
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| Veröffentlicht in: | Sleep medicine Jg. 50; S. 132 - 136 |
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| Abstract | Childhood obstructive sleep apnea–hypopnea syndrome (OSAHS), the most common sleep-related breathing disorder, may lead to cognitive impairment. This study aims to investigate the association between mild or moderate childhood OSAHS and cognitive dysfunction.
A total of 59 children (4–12 years of age) diagnosed with mild or moderate OSAHS by polysomnography and 60 age- and sex-matched healthy children were included in the study. The China-Wechsler Younger Children Scale of Intelligence and China-Wechsler Intelligence Scale for Children were used to evaluate the cognition of the participating children aged <6 years and ≥6 years, respectively.
In the <6-years-old subgroup, children with OSAHS had significantly lower scores of full-scale IQ (FIQ), verbal IQ (VIQ), comprehension test, and visual analysis than the healthy children (all p < 0.05). In the ≥6-years-old subgroup, VIQ and classification test scores were significantly lower in children with OSAHS than in the healthy controls (all p < 0.05). FIQ, VIQ, and performance IQ (PIQ) scores did not correlate with AHI, OAHI, and the lowest nocturnal SO2. Notably, in the <6-years-old subgroup of OSAHS, the accumulated time of SO2<90% (p = 0.046) and the percentage of the accumulated time of SO2<90% in the total sleep time (p = 0.034) correlated with PIQ negatively and significantly.
Mild to moderate childhood OSAHS may adversely affect cognitive function, particularly in young children (<6 years of age). This study may increase the awareness of childhood OSAHS-associated cognitive dysfunction and advocate early interventions in childhood OSAHS.
•Young children (<6 years) with OSAHS had lower scores of full scale and verbal IQ.•Young children with OSAHS performed less well in comprehension tests and visual analysis.•The accumulated time of SO2 <90% correlated with PIQ negatively in pediatric OSAHS. |
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| AbstractList | Childhood obstructive sleep apnea-hypopnea syndrome (OSAHS), the most common sleep-related breathing disorder, may lead to cognitive impairment. This study aims to investigate the association between mild or moderate childhood OSAHS and cognitive dysfunction.
A total of 59 children (4-12 years of age) diagnosed with mild or moderate OSAHS by polysomnography and 60 age- and sex-matched healthy children were included in the study. The China-Wechsler Younger Children Scale of Intelligence and China-Wechsler Intelligence Scale for Children were used to evaluate the cognition of the participating children aged <6 years and ≥6 years, respectively.
In the <6-years-old subgroup, children with OSAHS had significantly lower scores of full-scale IQ (FIQ), verbal IQ (VIQ), comprehension test, and visual analysis than the healthy children (all p < 0.05). In the ≥6-years-old subgroup, VIQ and classification test scores were significantly lower in children with OSAHS than in the healthy controls (all p < 0.05). FIQ, VIQ, and performance IQ (PIQ) scores did not correlate with AHI, OAHI, and the lowest nocturnal SO
. Notably, in the <6-years-old subgroup of OSAHS, the accumulated time of SO
<90% (p = 0.046) and the percentage of the accumulated time of SO
<90% in the total sleep time (p = 0.034) correlated with PIQ negatively and significantly.
Mild to moderate childhood OSAHS may adversely affect cognitive function, particularly in young children (<6 years of age). This study may increase the awareness of childhood OSAHS-associated cognitive dysfunction and advocate early interventions in childhood OSAHS. Childhood obstructive sleep apnea-hypopnea syndrome (OSAHS), the most common sleep-related breathing disorder, may lead to cognitive impairment. This study aims to investigate the association between mild or moderate childhood OSAHS and cognitive dysfunction.BACKGROUNDChildhood obstructive sleep apnea-hypopnea syndrome (OSAHS), the most common sleep-related breathing disorder, may lead to cognitive impairment. This study aims to investigate the association between mild or moderate childhood OSAHS and cognitive dysfunction.A total of 59 children (4-12 years of age) diagnosed with mild or moderate OSAHS by polysomnography and 60 age- and sex-matched healthy children were included in the study. The China-Wechsler Younger Children Scale of Intelligence and China-Wechsler Intelligence Scale for Children were used to evaluate the cognition of the participating children aged <6 years and ≥6 years, respectively.METHODSA total of 59 children (4-12 years of age) diagnosed with mild or moderate OSAHS by polysomnography and 60 age- and sex-matched healthy children were included in the study. The China-Wechsler Younger Children Scale of Intelligence and China-Wechsler Intelligence Scale for Children were used to evaluate the cognition of the participating children aged <6 years and ≥6 years, respectively.In the <6-years-old subgroup, children with OSAHS had significantly lower scores of full-scale IQ (FIQ), verbal IQ (VIQ), comprehension test, and visual analysis than the healthy children (all p < 0.05). In the ≥6-years-old subgroup, VIQ and classification test scores were significantly lower in children with OSAHS than in the healthy controls (all p < 0.05). FIQ, VIQ, and performance IQ (PIQ) scores did not correlate with AHI, OAHI, and the lowest nocturnal SO2. Notably, in the <6-years-old subgroup of OSAHS, the accumulated time of SO2<90% (p = 0.046) and the percentage of the accumulated time of SO2<90% in the total sleep time (p = 0.034) correlated with PIQ negatively and significantly.RESULTSIn the <6-years-old subgroup, children with OSAHS had significantly lower scores of full-scale IQ (FIQ), verbal IQ (VIQ), comprehension test, and visual analysis than the healthy children (all p < 0.05). In the ≥6-years-old subgroup, VIQ and classification test scores were significantly lower in children with OSAHS than in the healthy controls (all p < 0.05). FIQ, VIQ, and performance IQ (PIQ) scores did not correlate with AHI, OAHI, and the lowest nocturnal SO2. Notably, in the <6-years-old subgroup of OSAHS, the accumulated time of SO2<90% (p = 0.046) and the percentage of the accumulated time of SO2<90% in the total sleep time (p = 0.034) correlated with PIQ negatively and significantly.Mild to moderate childhood OSAHS may adversely affect cognitive function, particularly in young children (<6 years of age). This study may increase the awareness of childhood OSAHS-associated cognitive dysfunction and advocate early interventions in childhood OSAHS.CONCLUSIONSMild to moderate childhood OSAHS may adversely affect cognitive function, particularly in young children (<6 years of age). This study may increase the awareness of childhood OSAHS-associated cognitive dysfunction and advocate early interventions in childhood OSAHS. Childhood obstructive sleep apnea–hypopnea syndrome (OSAHS), the most common sleep-related breathing disorder, may lead to cognitive impairment. This study aims to investigate the association between mild or moderate childhood OSAHS and cognitive dysfunction. A total of 59 children (4–12 years of age) diagnosed with mild or moderate OSAHS by polysomnography and 60 age- and sex-matched healthy children were included in the study. The China-Wechsler Younger Children Scale of Intelligence and China-Wechsler Intelligence Scale for Children were used to evaluate the cognition of the participating children aged <6 years and ≥6 years, respectively. In the <6-years-old subgroup, children with OSAHS had significantly lower scores of full-scale IQ (FIQ), verbal IQ (VIQ), comprehension test, and visual analysis than the healthy children (all p < 0.05). In the ≥6-years-old subgroup, VIQ and classification test scores were significantly lower in children with OSAHS than in the healthy controls (all p < 0.05). FIQ, VIQ, and performance IQ (PIQ) scores did not correlate with AHI, OAHI, and the lowest nocturnal SO2. Notably, in the <6-years-old subgroup of OSAHS, the accumulated time of SO2<90% (p = 0.046) and the percentage of the accumulated time of SO2<90% in the total sleep time (p = 0.034) correlated with PIQ negatively and significantly. Mild to moderate childhood OSAHS may adversely affect cognitive function, particularly in young children (<6 years of age). This study may increase the awareness of childhood OSAHS-associated cognitive dysfunction and advocate early interventions in childhood OSAHS. •Young children (<6 years) with OSAHS had lower scores of full scale and verbal IQ.•Young children with OSAHS performed less well in comprehension tests and visual analysis.•The accumulated time of SO2 <90% correlated with PIQ negatively in pediatric OSAHS. |
| Author | Ni, Xin Liu, Haihong Jin, Xin Zhang, Jishui Peng, Xiaoxia Tian, Jinghong Zheng, Li Tai, Jun Wang, Guixiang Guo, Yongli Zhao, Jing Han, Shujing Zhang, Jie Wang, Hua Xu, Zhifei |
| Author_xml | – sequence: 1 givenname: Jing surname: Zhao fullname: Zhao, Jing organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 2 givenname: Shujing surname: Han fullname: Han, Shujing organization: Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 3 givenname: Jishui surname: Zhang fullname: Zhang, Jishui organization: Department of Neurorehabilitation, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 4 givenname: Guixiang surname: Wang fullname: Wang, Guixiang organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 5 givenname: Hua surname: Wang fullname: Wang, Hua organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 6 givenname: Zhifei surname: Xu fullname: Xu, Zhifei organization: Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 7 givenname: Jun surname: Tai fullname: Tai, Jun organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 8 givenname: Xiaoxia surname: Peng fullname: Peng, Xiaoxia organization: Center for Clinical Epidemiology & Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 9 givenname: Yongli surname: Guo fullname: Guo, Yongli organization: Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 10 givenname: Haihong surname: Liu fullname: Liu, Haihong organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 11 givenname: Jinghong surname: Tian fullname: Tian, Jinghong organization: Department of Neurorehabilitation, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 12 givenname: Xin surname: Jin fullname: Jin, Xin organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 13 givenname: Li surname: Zheng fullname: Zheng, Li organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 14 givenname: Jie surname: Zhang fullname: Zhang, Jie email: stzhangj@263.net organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China – sequence: 15 givenname: Xin surname: Ni fullname: Ni, Xin email: nixin@bch.com.cn organization: Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, 100045, China |
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| Keywords | Wechsler intelligence scale for children Children Cognitive function Obstructive sleep apnea–hypopnea syndrome |
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| Title | Association between mild or moderate obstructive sleep apnea-hypopnea syndrome and cognitive dysfunction in children |
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