Good Timing in the Cell Cycle for Precise DNA Repair by BRCA1

It is now clear that large DNA-binding proteins have evolved in mammals to orchestrate the relatively ancient processes of DNA recombinational repair. These proteins are recruited to accurately repair DNA double-strand breaks (DSBs) - the frequent, potentially lethal and mutagenic lesions in the gen...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 4; no. 9; pp. 1216 - 1222
Main Authors:	Durant, Stephen T., Nickoloff, Jac A
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.09.2005
Subjects:	Acid Anhydride Hydrolases Animals Binding Biology Bioscience BRCA1 Protein - physiology Calcium Cancer Cell Cell Cycle Cell Cycle Proteins - metabolism Cycle DNA - chemistry DNA Damage DNA Repair DNA Repair Enzymes - metabolism DNA Replication DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism G2 Phase Genes, BRCA1 Genome Heterozygote Humans Landes Models, Biological MRE11 Homologue Protein Mutagenesis Nuclear Proteins - metabolism Organogenesis Protein Binding Proteins S Phase Time Factors
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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