The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Lynch syndrome is the most common cause of hereditary colorectal cancer and is secondary to germline alterations in one of four DNA mismatch repair (MMR) genes. Here we aimed to provide novel insights into the initiation of MMR-deficient (MMRd) colorectal carcinogenesis by characterizing the express...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 81; no. 10; p. 2760
Main Authors:	Bommi, Prashant V, Bowen, Charles M, Reyes-Uribe, Laura, Wu, Wenhui, Katayama, Hiroyuki, Rocha, Pedro, Parra, Edwin R, Francisco-Cruz, Alejandro, Ozcan, Zuhal, Tosti, Elena, Willis, Jason A, Wu, Hong, Taggart, Melissa W, Burks, Jared K, Lynch, Patrick M, Edelmann, Winfried, Scheet, Paul A, Wistuba, Ignacio I, Sinha, Krishna M, Hanash, Samir M, Vilar, Eduardo
Format:	Journal Article
Language:	English
Published:	United States 15.05.2021
Subjects:	Animals Apoptosis Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Cell Proliferation Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism Colorectal Neoplasms, Hereditary Nonpolyposis - pathology DNA Mismatch Repair Gene Expression Regulation, Neoplastic Humans Intestines - physiopathology Mice Mice, Inbred C57BL Mice, Knockout MutS Homolog 2 Protein - physiology Prognosis Proteome - analysis Proteome - metabolism Receptors, G-Protein-Coupled - physiology Stem Cells - metabolism Stem Cells - pathology Survival Rate Transcriptome Tumor Cells, Cultured
ISSN:	1538-7445, 1538-7445
Online Access:	Get more information
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