Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds

Unraveling the associations between human exposure to environmental chemicals and potential neurotoxicity presents significant challenges. Evaluation of neurotoxicity potential using animal testing is resource-intensive (financial, labor, and animal use) and faces uncertainties regarding biological...

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Bibliographic Details
Published in:	Archives of toxicology Vol. 99; no. 7; pp. 2917 - 2935
Main Authors:	Carstens, Kelly E., Gronskaya, Elena, Jäckel, David, Bertoli, Jessica, Cuevas, Kelvin Ramirez, Dorier, Julien, Wang, Shan, Lopez-Rodriguez, David, Shafer, Timothy J., Zurich, Marie-Gabrielle, Pamies, David
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2025 Springer Nature B.V
Subjects:	Acetaminophen Animal models Animal research Arrays Assaying Astrocytes Astrocytes - drug effects Biological activity Biomedical and Life Sciences Biomedicine Brain Brain - cytology Brain - drug effects Cell culture Cells, Cultured Chemical activity Chemicals Cosmetics Domoic acid Electrodes Environmental Health Environmental Pollutants - toxicity High density Humans In vitro methods and tests In Vitro Systems Induced Pluripotent Stem Cells - drug effects Microelectrodes Microphysiological Systems Morphology Network formation Neural networks Neurons - drug effects Neurotoxicity Neurotoxicity Syndromes - etiology Occupational Medicine/Industrial Medicine Oligodendrocytes Oligodendroglia - drug effects Pharmacology/Toxicology Pluripotency Reproducibility Rodents Stem cells Toxicity Toxicity Tests - methods United States > US MPS 3D cultures Neurotoxicology iPSC MEA High-density electrode array Microelectrode array BrainSphere Neuronal electrical activity
ISSN:	0340-5761, 1432-0738, 1432-0738
Online Access:	Get full text
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