Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells

The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. However, only partial effects have been reported for candidate genes experimentally tested so far. Here we demonstrate that inactivation of two ovarian somatic...

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Vydáno v:	Human molecular genetics Ročník 16; číslo 23; s. 2795
Hlavní autoři:	Ottolenghi, Chris, Pelosi, Emanuele, Tran, Joseph, Colombino, Maria, Douglass, Eric, Nedorezov, Timur, Cao, Antonio, Forabosco, Antonino, Schlessinger, David
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.12.2007
Témata:	Animals Animals, Newborn Disorders of Sex Development Female Forkhead Box Protein L2 Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Germ Cells - cytology Germ Cells - metabolism Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Models, Biological Ovary - cytology Ovary - embryology Pregnancy Sex Determination Processes Sex Differentiation Testis - cytology Testis - embryology Wnt Proteins - deficiency Wnt Proteins - genetics Wnt Proteins - metabolism Wnt4 Protein
ISSN:	0964-6906
On-line přístup:	Zjistit podrobnosti o přístupu
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