IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia/reperfusion (I/R) injury

Background Ferroptosis is an important mechanism underlying cardiac ischemia/reperfusion (I/R) injury. However, the specific molecular mechanisms by which aerobic exercise alleviates cardiac I/R injury and inhibits ferroptosis remain unclear. Methods In this study, we investigated the effects of IGF...

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Veröffentlicht in:	Journal of translational medicine Jg. 23; H. 1; S. 1080 - 17
Hauptverfasser:	Yang, Chenguang, Meng, Xuyang, Xia, Chenxi, Sun, Youjing, Ren, Yirong, Wang, Jun, Li, Yi, Wang, Xiang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 13.10.2025 BioMed Central Ltd BMC
Schlagworte:	Aerobic exercise Aerobic exercises Animals Binding proteins Biomedical and Life Sciences Biomedicine Cardiomyocyte Cardiomyopathy Cardiovascular Care and treatment Causes of Cell death Complications and side effects Development and progression Ferroptosis Health aspects Heart diseases IGFBP2 Insulin-Like Growth Factor Binding Protein 2 - metabolism Iron in the body Ischemia/reperfusion injury Male Medicine/Public Health Metabolic and Lipoprotein Translation Mice Mice, Inbred C57BL Mice, Knockout Myocardial ischemia Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Physical Conditioning, Animal Physiological aspects Reperfusion injury Sirtuin 1 - metabolism China Ferroptosis Ischemia/reperfusion injury Cardiomyocyte IGFBP2 Aerobic exercise
ISSN:	1479-5876, 1479-5876
Online-Zugang:	Volltext
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