Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

Motivation: Imputation using external reference panels (e.g. 1000 Genomes) is a widely used approach for increasing power in genome-wide association studies and meta-analysis. Existing hidden Markov models (HMM)-based imputation approaches require individual-level genotypes. Here, we develop a new m...

Full description

Bibliographic Details

Published in:	Bioinformatics (Oxford, England) Vol. 30; no. 20; pp. 2906 - 2914
Main Authors:	Pasaniuc, Bogdan, Zaitlen, Noah, Shi, Huwenbo, Bhatia, Gaurav, Gusev, Alexander, Pickrell, Joseph, Hirschhorn, Joel, Strachan, David P., Patterson, Nick, Price, Alkes L.
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 15.10.2014
Subjects:	Algorithms Biostatistics - methods Case-Control Studies Cohort Studies Genome-Wide Association Study - methods Genotype Humans Linkage Disequilibrium Original Papers Phenotype Polymorphism, Single Nucleotide Software Time Factors
ISSN:	1367-4803, 1367-4811, 1367-4811
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!