Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease

Cumulative evidence indicates that the onset and severity of Huntington's disease (HD) symptoms correlate with connectivity deficits involving specific neuronal populations within cortical and basal ganglia circuits. Brain imaging studies and pathological reports further associated these defici...

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Bibliographic Details
Published in:	Human molecular genetics Vol. 24; no. 18; pp. 5285 - 5298
Main Authors:	Gatto, Rodolfo G, Chu, Yaping, Ye, Allen Q, Price, Steven D, Tavassoli, Ehsan, Buenaventura, Andrea, Brady, Scott T, Magin, Richard L, Kordower, Jeffrey H, Morfini, Gerardo A
Format:	Journal Article
Language:	English
Published:	England 15.09.2015
Subjects:	Aged Animals Axons - metabolism Axons - pathology Brain - metabolism Brain - pathology Cerebral Cortex - metabolism Cerebral Cortex - pathology Female Gene Expression Genes, Reporter Humans Huntington Disease - diagnosis Huntington Disease - metabolism Huntington Disease - pathology Male Mice Mice, Transgenic Microscopy, Confocal Middle Aged Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurons - metabolism Neurons - pathology Protein Aggregation, Pathological Serotonin Plasma Membrane Transport Proteins - metabolism Severity of Illness Index
ISSN:	1460-2083
Online Access:	Get more information
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