Involvement of Wnt, Eda and Shh at defined stages of sweat gland development

To maintain body temperature, sweat glands develop from embryonic ectoderm by a poorly defined mechanism. We demonstrate a temporal cascade of regulation during mouse sweat gland formation. Sweat gland induction failed completely when canonical Wnt signaling was blocked in skin epithelium, and was a...

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Bibliographic Details
Published in:	Development (Cambridge) Vol. 141; no. 19; p. 3752
Main Authors:	Cui, Chang-Yi, Yin, Mingzhu, Sima, Jian, Childress, Victoria, Michel, Marc, Piao, Yulan, Schlessinger, David
Format:	Journal Article
Language:	English
Published:	England 01.10.2014
Subjects:	Animals beta Catenin - deficiency DNA Primers - genetics Ectodysplasins - metabolism Fluorescent Antibody Technique Galactosides Gene Expression Profiling Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Hedgehog Proteins - metabolism In Situ Hybridization Indoles Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Mice Mice, Transgenic Real-Time Polymerase Chain Reaction Sweat Glands - embryology Sweat Glands - metabolism Wnt Proteins - metabolism Wnt Signaling Pathway - physiology Hyperhidrosis Mouse Exocrine gland Hair follicle Heatstroke Ectodermal dysplasia Skin appendage
ISSN:	1477-9129, 1477-9129
Online Access:	Get more information
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