The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects

The development of tau-PET allows paired helical filament tau pathology to be visualized in vivo. Increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting the progression of Alzheimer's disease. However, the factors modifying t...

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Vydáno v:	Brain (London, England : 1878) Ročník 143; číslo 12; s. 3805
Hlavní autoři:	Smith, Ruben, Strandberg, Olof, Mattsson-Carlgren, Niklas, Leuzy, Antoine, Palmqvist, Sebastian, Pontecorvo, Michael J, Devous, Michael D, Ossenkoppele, Rik, Hansson, Oskar
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.12.2020
Témata:	Aged Aged, 80 and over Aging - metabolism Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Apolipoprotein E4 - genetics Cerebral Cortex - diagnostic imaging Cerebral Cortex - metabolism Cognitive Dysfunction - metabolism Female Genotype Humans Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Neocortex - diagnostic imaging Neocortex - metabolism Positron-Emission Tomography Risk Factors Sex Characteristics tau Proteins - metabolism tau; PET; sex differences; Alzheimer’s disease; disease progression
ISSN:	1460-2156, 1460-2156
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