Flt3 ligand-treated neonatal mice have increased innate immunity against intracellular pathogens and efficiently control virus infections

Flt-3 ligand (FL), a hematopoetic growth factor, increases the number of dendritic cells (DCs), B cells, and natural killer cells in adult mice but the effect in neonates was unknown. We show that FL treatment of newborn mice induced a >100-fold increase in the innate resistance against infection...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 197; no. 5; p. 575
Main Authors:	Vollstedt, Sabine, Franchini, Marco, Hefti, Hans P, Odermatt, Bernhard, O'Keeffe, Meredith, Alber, Gottfried, Glanzmann, Bettina, Riesen, Matthias, Ackermann, Mathias, Suter, Mark
Format:	Journal Article
Language:	English
Published:	United States 03.03.2003
Subjects:	Animals Animals, Newborn B-Lymphocytes - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Flow Cytometry Herpes Simplex - immunology Herpesvirus 1, Human Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Immunity, Innate Interferon-alpha - metabolism Interferon-beta - metabolism Interleukin-12 - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Listeria monocytogenes Listeriosis - immunology Membrane Proteins - pharmacology Mice Mice, Inbred Strains Mice, Knockout Skin - cytology Skin - metabolism Spleen - cytology Spleen - metabolism Survival Rate
ISSN:	0022-1007
Online Access:	Get more information
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