Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

Early detection of pancreatic ductal adenocarcinoma (PDAC) remains elusive. Precursor lesions of PDAC, specifically intraductal papillary mucinous neoplasms (IPMNs), represent a pathway to invasive neoplasia, although the molecular correlates of progression remain to be fully elucidated. Single-cell...

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Bibliographic Details

Published in:	Clinical cancer research Vol. 25; no. 7; p. 2194
Main Authors:	Bernard, Vincent, Semaan, Alexander, Huang, Jonathan, San Lucas, F Anthony, Mulu, Feven C, Stephens, Bret M, Guerrero, Paola A, Huang, Yanqing, Zhao, Jun, Kamyabi, Nabiollah, Sen, Subrata, Scheet, Paul A, Taniguchi, Cullen M, Kim, Michael P, Tzeng, Ching-Wei, Katz, Matthew H, Singhi, Aatur D, Maitra, Anirban, Alvarez, Hector A
Format:	Journal Article
Language:	English
Published:	United States 01.04.2019
Subjects:	Adenocarcinoma, Mucinous - genetics Carcinoma, Pancreatic Ductal - genetics Disease Progression Humans Pancreatic Neoplasms - genetics Phenotype Tumor Microenvironment
ISSN:	1557-3265, 1557-3265
Online Access:	Get more information
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