Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics

Induced pluripotent stem cell (iPSC)-derived cortical neurons potentially present a powerful new model to understand corticogenesis and neurological disease. Previous work has established that differentiation protocols can produce cortical neurons, but little has been done to characterize these at c...

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Veröffentlicht in:	Human molecular genetics Jg. 25; H. 5; S. 989
Hauptverfasser:	Handel, Adam E, Chintawar, Satyan, Lalic, Tatjana, Whiteley, Emma, Vowles, Jane, Giustacchini, Alice, Argoud, Karene, Sopp, Paul, Nakanishi, Mahito, Bowden, Rory, Cowley, Sally, Newey, Sarah, Akerman, Colin, Ponting, Chris P, Cader, M Zameel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.03.2016
Schlagworte:	Adult Aged Biomarkers - metabolism Cell Differentiation Cell Line Cerebral Cortex - cytology Cerebral Cortex - metabolism Female Fetus Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Profiling Gene Expression Regulation, Developmental Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurogenesis - genetics Neurons - cytology Neurons - metabolism Real-Time Polymerase Chain Reaction Receptors, Glutamate - genetics Receptors, Glutamate - metabolism Sequence Analysis, RNA Single-Cell Analysis Transcriptome
ISSN:	1460-2083, 1460-2083
Online-Zugang:	Weitere Angaben
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