Targeted Brain Tumor Radiotherapy Using an Auger Emitter

Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent decades. I-MAPi (Iodine-123 Meitner-Auger PARP1 inhibitor) is a precis...

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Veröffentlicht in:	Clinical cancer research Jg. 26; H. 12; S. 2871
Hauptverfasser:	Pirovano, Giacomo, Jannetti, Stephen A, Carter, Lukas M, Sadique, Ahmad, Kossatz, Susanne, Guru, Navjot, Demétrio De Souza França, Paula, Maeda, Masatomo, Zeglis, Brian M, Lewis, Jason S, Humm, John L, Reiner, Thomas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.06.2020
Schlagworte:	Animals Apoptosis Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Cell Proliferation Female Glioblastoma - drug therapy Glioblastoma - pathology Glioblastoma - radiotherapy Humans Iodine Radioisotopes - therapeutic use Mice Mice, Nude Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Radiotherapy - methods Tumor Cells, Cultured Xenograft Model Antitumor Assays
ISSN:	1557-3265, 1557-3265
Online-Zugang:	Weitere Angaben
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