Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, IFN production, and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 76; H. 8; S. 2137
Hauptverfasser:	Tang, Chih-Hang Anthony, Zundell, Joseph A, Ranatunga, Sujeewa, Lin, Cindy, Nefedova, Yulia, Del Valle, Juan R, Hu, Chih-Chi Andrew
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.04.2016
Schlagworte:	Animals Apoptosis - physiology B-Lymphocytes - cytology B-Lymphocytes - metabolism Cell Line Cyclic GMP - administration & dosage Cyclic GMP - pharmacology Injections, Intraperitoneal Membrane Proteins - agonists Membrane Proteins - physiology Mice
ISSN:	1538-7445, 1538-7445
Online-Zugang:	Weitere Angaben
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