Defects in Emerin-Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis

Nuclear envelope proteins play an important role in regulating nuclear size and structure in cancer. Altered expression of nuclear lamins are found in many cancers and its expression is correlated with better clinical outcomes. The nucleus is the largest organelle in the cell with a diameter between...

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Bibliographic Details
Published in:	Molecular cancer research Vol. 19; no. 7; p. 1196
Main Authors:	Liddane, Alexandra G, McNamara, Chelsea A, Campbell, Mallory C, Mercier, Isabelle, Holaska, James M
Format:	Journal Article
Language:	English
Published:	United States 01.07.2021
Subjects:	Animals Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Cycle - genetics Cell Line Cell Line, Tumor Cell Movement - genetics Cell Nucleus - genetics Cell Nucleus - metabolism Cell Proliferation - genetics Cells, Cultured Female Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Nude Microscopy, Confocal - methods Neoplasm Metastasis Nuclear Matrix - genetics Nuclear Matrix - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Transplantation, Heterologous
ISSN:	1557-3125, 1557-3125
Online Access:	Get more information
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