Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat

Chronic administration of cocaine has been shown to attenuate the functional capacity of delta opioid receptors to inhibit adenylyl cyclase activity. Abuse and withdrawal from cocaine in humans is associated with increases in anxiety and depression. Since recent research supports the role of delta o...

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Bibliographic Details
Published in:	Neuropharmacology Vol. 54; no. 2; pp. 355 - 364
Main Authors:	Perrine, Shane A., Sheikh, Imran S., Nwaneshiudu, Chinwe A., Schroeder, Joseph A., Unterwald, Ellen M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.02.2008
Subjects:	Adenylyl cyclase Adenylyl Cyclases - metabolism Animals Anxiety Anxiety - psychology Behavior, Animal - drug effects Benzamides - pharmacology Cocaine Cocaine - adverse effects Data Interpretation, Statistical Delta opioid receptor Depression Depression - psychology Male Motor Activity - drug effects Piperazines - pharmacology Rat Rats Rats, Sprague-Dawley Receptors, Opioid, delta - agonists Receptors, Opioid, delta - drug effects Signal Transduction - drug effects SNC80 Substance Withdrawal Syndrome - physiopathology Swimming - psychology Rat Adenylyl cyclase SNC80 Depression Cocaine Anxiety Delta opioid receptor
ISSN:	0028-3908, 1873-7064
Online Access:	Get full text
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