Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

Small‐molecule modulation of protein–protein interactions (PPIs) is one of the most promising new areas in drug discovery. In the vast majority of cases only inhibition or disruption of PPIs is realized, whereas the complementary strategy of targeted stabilization of PPIs is clearly under‐represente...

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Bibliographic Details
Published in:	ChemMedChem Vol. 11; no. 8; pp. 911 - 918
Main Authors:	Bier, David, Bartel, Maria, Sies, Katharina, Halbach, Sebastian, Higuchi, Yusuke, Haranosono, Yu, Brummer, Tilman, Kato, Nobuo, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 19.04.2016 Wiley Subscription Services, Inc
Subjects:	14-3-3 Proteins - chemistry 14-3-3 Proteins - metabolism Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology Crystal structure Crystallography, X-Ray Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Dose-Response Relationship, Drug Drug Stability Glycosides - chemical synthesis Glycosides - chemistry Glycosides - pharmacology Humans Models, Molecular Molecular Conformation natural products Protein Binding - drug effects protein-protein interactions Proteins semi-synthesis Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology small molecules Structure-Activity Relationship Tumor Cells, Cultured X-ray protein crystallography natural products semi-synthesis small molecules X-ray protein crystallography protein-protein interactions
ISSN:	1860-7179, 1860-7187, 1860-7187
Online Access:	Get full text
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