The structural determinants of checkpoint activation

Here, we demonstrate that primed, single-stranded DNA (ssDNA) is sufficient for activation of the ATR-dependent checkpoint pathway in Xenopus egg extracts. Using this structure, we define the contribution of the 5'- and 3'-primer ends to Chk1 activation when replication is blocked and ongo...

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Bibliographic Details

Published in:	Genes & development Vol. 21; no. 8; p. 898
Main Authors:	MacDougall, Christina A, Byun, Tony S, Van, Christopher, Yee, Muh-ching, Cimprich, Karlene A
Format:	Journal Article
Language:	English
Published:	United States 15.04.2007
Subjects:	Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle Cell Cycle Proteins - metabolism Checkpoint Kinase 1 DNA Damage DNA Replication DNA, Single-Stranded - metabolism Ovum - chemistry Phosphorylation Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism S Phase Xenopus laevis Xenopus Proteins - metabolism
ISSN:	0890-9369
Online Access:	Get more information
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