PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element

The transcription factor PU.1 is an important regulator of hematopoiesis; precise expression levels are critical for normal hematopoietic development and suppression of leukemia. We show here that noncoding antisense RNAs are important modulators of proper dosages of PU.1. Antisense and sense RNAs a...

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Bibliographic Details
Published in:	Genes & development Vol. 22; no. 15; p. 2085
Main Authors:	Ebralidze, Alexander K, Guibal, Florence C, Steidl, Ulrich, Zhang, Pu, Lee, Sanghoon, Bartholdy, Boris, Jorda, Meritxell Alberich, Petkova, Victoria, Rosenbauer, Frank, Huang, Gang, Dayaram, Tajhal, Klupp, Johanna, O'Brien, Karen B, Will, Britta, Hoogenkamp, Maarten, Borden, Katherine L B, Bonifer, Constanze, Tenen, Daniel G
Format:	Journal Article
Language:	English
Published:	United States 01.08.2008
Subjects:	Animals Cell Line Electroporation Gene Expression Granulocytes - cytology Granulocytes - metabolism HL-60 Cells Humans Immunomagnetic Separation Jurkat Cells Macrophages - metabolism Mice Models, Genetic Protein Biosynthesis Proto-Oncogene Proteins - genetics Regulatory Sequences, Nucleic Acid - genetics RNA Interference RNA, Antisense - genetics RNA, Antisense - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - metabolism T-Lymphocytes - metabolism Trans-Activators - genetics Transcription, Genetic U937 Cells
ISSN:	0890-9369
Online Access:	Get more information
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