Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm

This study examined whether selective destruction of cholinergic neurons in the medial septum impairs acquisition of a delayed matching-to-position (DMP) spatial memory task. Either the selective immunotoxin 192 IgG-saporin (SAP; 0.22 or 1.0 μg) or the non-selective excitatory neurotoxin ibotenate (...

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Bibliographic Details
Published in:	Brain research Vol. 943; no. 1; pp. 132 - 141
Main Authors:	Johnson, David A, Zambon, Natalie J, Gibbs, Robert B
Format:	Journal Article
Language:	English
Published:	London Elsevier B.V 05.07.2002 Amsterdam Elsevier New York, NY
Subjects:	Acetylcholine Animals Antibodies, Monoclonal - toxicity Basal forebrain Behavioral psychophysiology Biological and medical sciences Choline O-Acetyltransferase - metabolism Cholinergic Fibers - drug effects Cholinergic Fibers - physiology Cognitive impairment Fundamental and applied biological sciences. Psychology Ibotenate Immunotoxins - toxicity Male Maze Learning - drug effects Maze Learning - physiology N-Glycosyl Hydrolases Neurotransmission and behavior Prosencephalon - drug effects Prosencephalon - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Ribosome Inactivating Proteins, Type 1 Saporins Septal Nuclei - cytology Septal Nuclei - drug effects Septal Nuclei - physiology Spatial memory Basal forebrain Acetylcholine Ibotenate Neurotransmitters, modulators, transporters, and receptors Spatial memory Cognitive impairment Cholinergic neuron Rat Septum nucleus Rodentia Central nervous system Vertebrata Mammalia Animal Neurotransmitter Lesion Brain (vertebrata)
ISSN:	0006-8993, 1872-6240
Online Access:	Get full text
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