Molecular insight in the multifunctional activities of Withaferin A

Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities. Even today the...

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Bibliographic Details
Published in:Biochemical pharmacology Vol. 84; no. 10; pp. 1282 - 1291
Main Authors: Vanden Berghe, Wim, Sabbe, Linde, Kaileh, Mary, Haegeman, Guy, Heyninck, Karen
Format: Journal Article
Language:English
Published: England Elsevier Inc 15.11.2012
Subjects:
Angiogenesis
Angiogenesis Inhibitors
Angiogenesis Inhibitors - chemistry
Angiogenesis Inhibitors - pharmacology
Animals
Anti-Inflammatory Agents
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
anticarcinogenic activity
Antineoplastic Agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antioxidants
apoptosis
Apoptosis - drug effects
Ayurvedic medicine
Carcinogenesis
cardioprotective effect
Cell Line, Tumor
chemistry
drug effects
health promotion
Heat-Shock Proteins
Heat-Shock Proteins - metabolism
herbal medicines
Humans
Inflammation
medicinal plants
metabolism
NF-kappa B
NF-kappa B - metabolism
people
pharmacology
Proteasome Endopeptidase Complex
Proteasome Endopeptidase Complex - metabolism
Protein Kinase Inhibitors
Protein Kinase Inhibitors - chemistry
Protein Kinase Inhibitors - pharmacology
proteins
Therapy
Transcription, Genetic
Withaferin A
Withania somnifera
Withanolides
Withanolides - chemistry
Withanolides - pharmacology
Withaferin A
Angiogenesis
Therapy
Inflammation
Carcinogenesis
ISSN:0006-2952, 1873-2968, 1873-2968
Online Access:Get full text
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Summary:Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities. Even today the popularity of medicinal herbs is still growing like in traditional medicines such as the Indian medicine, Ayurveda. One of the Ayurvedic medicinal plants is Withania somnifera Dunal, of which the important constituents are the withanolides. Among them, Withaferin A is one of the most bioactive compounds, exerting anti-inflammatory, pro-apoptotic but also anti-invasive and anti-angiogenic effects. In the context of modern pharmacology, a better insight in the underlying mechanism of the broad range of bioactivities exerted by Withaferin A is compulsory. Therefore, a lot of effort was made to explore the intracellular effects of Withaferin A and to characterize its target proteins. This review provides a decisive insight on the molecular basis of the health-promoting potential of Withaferin A.
Bibliography:http://dx.doi.org/10.1016/j.bcp.2012.08.027
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ISSN:0006-2952
1873-2968
1873-2968
DOI:10.1016/j.bcp.2012.08.027