Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Blocking Programmed Death-1 (PD-1) can reinvigorate exhausted CD8 T cells (T ) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram T into durable memory T cells (T ) is unclear. We found that reinvigoration of T in mice by PD-L1 blockade caused minimal...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 354; H. 6316; S. 1160
Hauptverfasser:	Pauken, Kristen E, Sammons, Morgan A, Odorizzi, Pamela M, Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M, Chen, Zeyu, Sen, Debattama R, Kurachi, Makoto, Barnitz, R Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C, Schenkel, Jason M, Vahedi, Golnaz, Haining, W Nicholas, Berger, Shelley L, Wherry, E John
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 02.12.2016
Schlagworte:	Animals B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - genetics CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Lineage - genetics Cellular Reprogramming - genetics Cellular Reprogramming - immunology Epigenesis, Genetic Female Gene Regulatory Networks Immunologic Memory - genetics Immunotherapy Interleukin-7 - metabolism Mice Mice, Inbred C57BL Transcription, Genetic
ISSN:	1095-9203, 1095-9203
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